Lumbar spine abnormalities in patients with obstructive sleep apnoea

Abstract Previous studies suggested cervical spondylosis as a risk factor for development of obstructive sleep apnoea (OSA). We aimed to assess lumbar disc degeneration in patients with OSA and correlate the findings with symptoms and disease severity. Twenty-seven patients with OSA and 29 non-OSA c...

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Autores principales:	Adam Domonkos Tarnoki, David Laszlo Tarnoki, Csaba Oláh, Marcell Szily, Daniel T. Kovacs, András Dienes, Marton Piroska, Bianka Forgo, Marina Pinheiro, Paulo Ferreira, László Kostyál, Martina Meszaros, Judit Pako, Laszlo Kunos, Andras Bikov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1e0ddc864c84fec94251b2383f6d925
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spelling	oai:doaj.org-article:f1e0ddc864c84fec94251b2383f6d9252021-12-02T15:07:54ZLumbar spine abnormalities in patients with obstructive sleep apnoea10.1038/s41598-021-95667-32045-2322https://doaj.org/article/f1e0ddc864c84fec94251b2383f6d9252021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95667-3https://doaj.org/toc/2045-2322Abstract Previous studies suggested cervical spondylosis as a risk factor for development of obstructive sleep apnoea (OSA). We aimed to assess lumbar disc degeneration in patients with OSA and correlate the findings with symptoms and disease severity. Twenty-seven patients with OSA and 29 non-OSA controls underwent sleep studies and lumbar magnetic resonance imaging (MRI), and completed the Epworth Sleepiness Scale and the 24-item Roland‐Morris Disability Questionnaire (RMDQ) questionnaires. Plasma klotho was determined with enzyme-linked immunosorbent assay. Patients with OSA had higher number of disc bulges (4.6 ± 3.7 vs. 1.7 ± 2.5, p < 0.01) and anterior spondylophytes (2.7 ± 4.2 vs. 0.8 ± 2.1, p < 0.01), increased disc degeneration (total Pfirrmann score 16.7 ± 4.7 vs. 13.2 ± 4.1, p < 0.01) and vertebral fatty degeneration (7.8 ± 4.7 vs. 3.8 ± 3.7, p < 0.01). There was no difference in the RMDQ score (0/0–3.5/ vs. 0/0–1/, p > 0.05). Markers of OSA severity, including the oxygen desaturation index and percentage of total sleep time spent with saturation < 90% as well as plasma levels of klotho were correlated with the number of disc bulges and anterior spondylophytes (all p < 0.05). OSA is associated with lumbar spondylosis. Our study highlights the importance of lumbar imaging in patients with OSA reporting lower back pain.Adam Domonkos TarnokiDavid Laszlo TarnokiCsaba OláhMarcell SzilyDaniel T. KovacsAndrás DienesMarton PiroskaBianka ForgoMarina PinheiroPaulo FerreiraLászló KostyálMartina MeszarosJudit PakoLaszlo KunosAndras BikovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adam Domonkos Tarnoki David Laszlo Tarnoki Csaba Oláh Marcell Szily Daniel T. Kovacs András Dienes Marton Piroska Bianka Forgo Marina Pinheiro Paulo Ferreira László Kostyál Martina Meszaros Judit Pako Laszlo Kunos Andras Bikov Lumbar spine abnormalities in patients with obstructive sleep apnoea
description	Abstract Previous studies suggested cervical spondylosis as a risk factor for development of obstructive sleep apnoea (OSA). We aimed to assess lumbar disc degeneration in patients with OSA and correlate the findings with symptoms and disease severity. Twenty-seven patients with OSA and 29 non-OSA controls underwent sleep studies and lumbar magnetic resonance imaging (MRI), and completed the Epworth Sleepiness Scale and the 24-item Roland‐Morris Disability Questionnaire (RMDQ) questionnaires. Plasma klotho was determined with enzyme-linked immunosorbent assay. Patients with OSA had higher number of disc bulges (4.6 ± 3.7 vs. 1.7 ± 2.5, p < 0.01) and anterior spondylophytes (2.7 ± 4.2 vs. 0.8 ± 2.1, p < 0.01), increased disc degeneration (total Pfirrmann score 16.7 ± 4.7 vs. 13.2 ± 4.1, p < 0.01) and vertebral fatty degeneration (7.8 ± 4.7 vs. 3.8 ± 3.7, p < 0.01). There was no difference in the RMDQ score (0/0–3.5/ vs. 0/0–1/, p > 0.05). Markers of OSA severity, including the oxygen desaturation index and percentage of total sleep time spent with saturation < 90% as well as plasma levels of klotho were correlated with the number of disc bulges and anterior spondylophytes (all p < 0.05). OSA is associated with lumbar spondylosis. Our study highlights the importance of lumbar imaging in patients with OSA reporting lower back pain.
format	article
author	Adam Domonkos Tarnoki David Laszlo Tarnoki Csaba Oláh Marcell Szily Daniel T. Kovacs András Dienes Marton Piroska Bianka Forgo Marina Pinheiro Paulo Ferreira László Kostyál Martina Meszaros Judit Pako Laszlo Kunos Andras Bikov
author_facet	Adam Domonkos Tarnoki David Laszlo Tarnoki Csaba Oláh Marcell Szily Daniel T. Kovacs András Dienes Marton Piroska Bianka Forgo Marina Pinheiro Paulo Ferreira László Kostyál Martina Meszaros Judit Pako Laszlo Kunos Andras Bikov
author_sort	Adam Domonkos Tarnoki
title	Lumbar spine abnormalities in patients with obstructive sleep apnoea
title_short	Lumbar spine abnormalities in patients with obstructive sleep apnoea
title_full	Lumbar spine abnormalities in patients with obstructive sleep apnoea
title_fullStr	Lumbar spine abnormalities in patients with obstructive sleep apnoea
title_full_unstemmed	Lumbar spine abnormalities in patients with obstructive sleep apnoea
title_sort	lumbar spine abnormalities in patients with obstructive sleep apnoea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f1e0ddc864c84fec94251b2383f6d925
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Lumbar spine abnormalities in patients with obstructive sleep apnoea

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