Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept.
<h4>Background</h4>Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties.<h4>Objectives</h4>The study a...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f1e3224571e94dc0b73c6a04a6632892 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f1e3224571e94dc0b73c6a04a6632892 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f1e3224571e94dc0b73c6a04a66328922021-11-18T08:01:38ZEndothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept.1932-620310.1371/journal.pone.0053658https://doaj.org/article/f1e3224571e94dc0b73c6a04a66328922013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23341966/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties.<h4>Objectives</h4>The study aimed to assess early EPCs levels and EPCs endogenous vascular endothelial growth factor (VEGF) expression in IPF. In order to examine alterations in the mobilization of EPCs from the bone marrow we measured plasma VEGF.<h4>Main results</h4>Twenty-three patients with IPF and fifteen healthy subjects were included. The number of early EPCs colonies was markedly reduced in IPF patients vs controls (6.00±6.49 vs 49.68±16.73, respectively, p<0.001). EPCs were further decreased in patients presenting systolic pulmonary arterial pressure (sPAP)≥35 mmHg. The number of colonies per well correlated negatively with P((A-a))O(2) (r = -0.750, p<0.001). Additionally, VEGF mRNA levels were significantly increased in IPF patients. There were no differences observed in VEGF plasma levels in IPF patients when compared to controls.<h4>Conclusions</h4>The current data suggest that inadequate levels of early EPCs may potentially contribute to suppressed repair and recovery of the damaged pulmonary endothelium and thereby may drive the sequence of events in profibrogenic direction. Increased VEGFmRNA levels in the clinical context of IPF may represent a compensatory mechanism to overcome reduced EPCs levels.Foteini MalliAngela KoutsokeraEfrosini ParaskevaEpaminondas ZakynthinosMaria PapagianniDimosthenes MakrisIrene TsilioniPaschalis Adam MolyvdasKonstantinos I GourgoulianisZoe DaniilPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53658 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Foteini Malli Angela Koutsokera Efrosini Paraskeva Epaminondas Zakynthinos Maria Papagianni Dimosthenes Makris Irene Tsilioni Paschalis Adam Molyvdas Konstantinos I Gourgoulianis Zoe Daniil Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept. |
| description |
<h4>Background</h4>Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties.<h4>Objectives</h4>The study aimed to assess early EPCs levels and EPCs endogenous vascular endothelial growth factor (VEGF) expression in IPF. In order to examine alterations in the mobilization of EPCs from the bone marrow we measured plasma VEGF.<h4>Main results</h4>Twenty-three patients with IPF and fifteen healthy subjects were included. The number of early EPCs colonies was markedly reduced in IPF patients vs controls (6.00±6.49 vs 49.68±16.73, respectively, p<0.001). EPCs were further decreased in patients presenting systolic pulmonary arterial pressure (sPAP)≥35 mmHg. The number of colonies per well correlated negatively with P((A-a))O(2) (r = -0.750, p<0.001). Additionally, VEGF mRNA levels were significantly increased in IPF patients. There were no differences observed in VEGF plasma levels in IPF patients when compared to controls.<h4>Conclusions</h4>The current data suggest that inadequate levels of early EPCs may potentially contribute to suppressed repair and recovery of the damaged pulmonary endothelium and thereby may drive the sequence of events in profibrogenic direction. Increased VEGFmRNA levels in the clinical context of IPF may represent a compensatory mechanism to overcome reduced EPCs levels. |
| format |
article |
| author |
Foteini Malli Angela Koutsokera Efrosini Paraskeva Epaminondas Zakynthinos Maria Papagianni Dimosthenes Makris Irene Tsilioni Paschalis Adam Molyvdas Konstantinos I Gourgoulianis Zoe Daniil |
| author_facet |
Foteini Malli Angela Koutsokera Efrosini Paraskeva Epaminondas Zakynthinos Maria Papagianni Dimosthenes Makris Irene Tsilioni Paschalis Adam Molyvdas Konstantinos I Gourgoulianis Zoe Daniil |
| author_sort |
Foteini Malli |
| title |
Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept. |
| title_short |
Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept. |
| title_full |
Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept. |
| title_fullStr |
Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept. |
| title_full_unstemmed |
Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept. |
| title_sort |
endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/f1e3224571e94dc0b73c6a04a6632892 |
| work_keys_str_mv |
AT foteinimalli endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT angelakoutsokera endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT efrosiniparaskeva endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT epaminondaszakynthinos endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT mariapapagianni endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT dimosthenesmakris endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT irenetsilioni endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT paschalisadammolyvdas endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT konstantinosigourgoulianis endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept AT zoedaniil endothelialprogenitorcellsinthepathogenesisofidiopathicpulmonaryfibrosisanevolvingconcept |
| _version_ |
1718422640773824512 |