TNF-α and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis.

<h4>Background</h4>Nitric oxide (NO), a key antimicrobial molecule, was previously shown to exert a dual role in paracoccidioidomycosis, an endemic fungal infection in Latin America. In the intravenous and peritoneal models of infection, NO production was associated with efficient fungal...

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Autores principales: Simone Bernardino, Adriana Pina, Maíra Felonato, Tânia A Costa, Eliseu Frank de Araújo, Cláudia Feriotti, Silvia Boschi Bazan, Alexandre C Keller, Katia R M Leite, Vera L G Calich
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/f1e5250709334ff4a51d901542c4d19b
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