Comparison of the Effect of Mefenamic Acid and Matricaria Camomilla Capsules on Primary Dysmenorrhea

BACKGROUND AND OBJECTIVE: The most common pelvic cyclic pain and the most common complaint of gynecologic patients is dysmenorrhea that causes many personal and social problems. Mefenamic acid with a lot of side effects and matricaria camomilla are useful for treatment of primary dysmenorrhea. The a...

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Autores principales: M Modarres, M Mirmohhamad Ali, Z Oshrieh, A Mehran
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Publicado: Babol University of Medical Sciences 2011
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spelling oai:doaj.org-article:f1e6dc9b85f04af588d6b3dd405448cb2021-11-10T08:56:34ZComparison of the Effect of Mefenamic Acid and Matricaria Camomilla Capsules on Primary Dysmenorrhea1561-41072251-7170https://doaj.org/article/f1e6dc9b85f04af588d6b3dd405448cb2011-05-01T00:00:00Zhttp://jbums.org/article-1-3803-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: The most common pelvic cyclic pain and the most common complaint of gynecologic patients is dysmenorrhea that causes many personal and social problems. Mefenamic acid with a lot of side effects and matricaria camomilla are useful for treatment of primary dysmenorrhea. The aim of this study was to compare the effect of mefenamic acid and matricaria camomilla capsules on primary dysmenorrhea.METHODS: This cross over, triple-blind randomized clinical trial study was performed on 80 students with primary dysmenorrhea, staying in Tehran University dormitory. They were randomly allocated to mefenamic acid and matricaria camomilla groups. Research took place in three stages. In the first stage, all students for two consecutive cycles in regard to suffering from second or third degree dysmenorrhea were examined. In the second stage, mefenamic acid or matricaria camomilla capsules with check list for the amount of bleeding and VAS scale were randomly given to each of the research units. In the third stage, each research unit received the same treatment of the opposite group with the same characteristics (crossover treatment) and for another two consecutive cycles this same method with replacing the medicine was repeated again. Each person was studied for 6 cycles. The patient marked the intensity of their pain on the visual analogue scale an hour before taking the first dose of the medicine and also 1 hour, 2 hours, 4 hours, and 48 hours after taking the first dose.FINDINGS: The mean age in both groups was 24.72±2.55 years. The mean of pain severity before treatment was 4.65±0.47 and after treatment was 2.80±1.04 and 1.12±0.43 in the mefenamic acid and matricaria camomilla groups, respectively that in comparison to the sign of pain it was revealed that the severity of pain decreased after two treatment cycles in the two groups receiving mefenamic acid and matricaria camomilla capsules. But this decrease in the matricaria camomilla group was considerable (p<0.001). CONCLUSION: The results of this study showed that taking matricaria camomilla capsule can decrease the severity of dysmenorrhea, so it is recommended to use it in the treatment of this common gynecologic disorder in women.M Modarres,M Mirmohhamad Ali,Z OshriehA MehranBabol University of Medical Sciencesarticlematricaria camomillamefenamic aciddysmenorrheaMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 3, Pp 50-58 (2011)
institution DOAJ
collection DOAJ
language EN
FA
topic matricaria camomilla
mefenamic acid
dysmenorrhea
Medicine
R
Medicine (General)
R5-920
spellingShingle matricaria camomilla
mefenamic acid
dysmenorrhea
Medicine
R
Medicine (General)
R5-920
M Modarres,
M Mirmohhamad Ali,
Z Oshrieh
A Mehran
Comparison of the Effect of Mefenamic Acid and Matricaria Camomilla Capsules on Primary Dysmenorrhea
description BACKGROUND AND OBJECTIVE: The most common pelvic cyclic pain and the most common complaint of gynecologic patients is dysmenorrhea that causes many personal and social problems. Mefenamic acid with a lot of side effects and matricaria camomilla are useful for treatment of primary dysmenorrhea. The aim of this study was to compare the effect of mefenamic acid and matricaria camomilla capsules on primary dysmenorrhea.METHODS: This cross over, triple-blind randomized clinical trial study was performed on 80 students with primary dysmenorrhea, staying in Tehran University dormitory. They were randomly allocated to mefenamic acid and matricaria camomilla groups. Research took place in three stages. In the first stage, all students for two consecutive cycles in regard to suffering from second or third degree dysmenorrhea were examined. In the second stage, mefenamic acid or matricaria camomilla capsules with check list for the amount of bleeding and VAS scale were randomly given to each of the research units. In the third stage, each research unit received the same treatment of the opposite group with the same characteristics (crossover treatment) and for another two consecutive cycles this same method with replacing the medicine was repeated again. Each person was studied for 6 cycles. The patient marked the intensity of their pain on the visual analogue scale an hour before taking the first dose of the medicine and also 1 hour, 2 hours, 4 hours, and 48 hours after taking the first dose.FINDINGS: The mean age in both groups was 24.72±2.55 years. The mean of pain severity before treatment was 4.65±0.47 and after treatment was 2.80±1.04 and 1.12±0.43 in the mefenamic acid and matricaria camomilla groups, respectively that in comparison to the sign of pain it was revealed that the severity of pain decreased after two treatment cycles in the two groups receiving mefenamic acid and matricaria camomilla capsules. But this decrease in the matricaria camomilla group was considerable (p<0.001). CONCLUSION: The results of this study showed that taking matricaria camomilla capsule can decrease the severity of dysmenorrhea, so it is recommended to use it in the treatment of this common gynecologic disorder in women.
format article
author M Modarres,
M Mirmohhamad Ali,
Z Oshrieh
A Mehran
author_facet M Modarres,
M Mirmohhamad Ali,
Z Oshrieh
A Mehran
author_sort M Modarres,
title Comparison of the Effect of Mefenamic Acid and Matricaria Camomilla Capsules on Primary Dysmenorrhea
title_short Comparison of the Effect of Mefenamic Acid and Matricaria Camomilla Capsules on Primary Dysmenorrhea
title_full Comparison of the Effect of Mefenamic Acid and Matricaria Camomilla Capsules on Primary Dysmenorrhea
title_fullStr Comparison of the Effect of Mefenamic Acid and Matricaria Camomilla Capsules on Primary Dysmenorrhea
title_full_unstemmed Comparison of the Effect of Mefenamic Acid and Matricaria Camomilla Capsules on Primary Dysmenorrhea
title_sort comparison of the effect of mefenamic acid and matricaria camomilla capsules on primary dysmenorrhea
publisher Babol University of Medical Sciences
publishDate 2011
url https://doaj.org/article/f1e6dc9b85f04af588d6b3dd405448cb
work_keys_str_mv AT mmodarres comparisonoftheeffectofmefenamicacidandmatricariacamomillacapsulesonprimarydysmenorrhea
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AT zoshrieh comparisonoftheeffectofmefenamicacidandmatricariacamomillacapsulesonprimarydysmenorrhea
AT amehran comparisonoftheeffectofmefenamicacidandmatricariacamomillacapsulesonprimarydysmenorrhea
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