Simulated transient hearing loss improves auditory sensitivity

Abstract Recently, it was proposed that a processing principle called adaptive stochastic resonance plays a major role in the auditory system, and serves to maintain optimal sensitivity even to highly variable sound pressure levels. As a side effect, in case of reduced auditory input, such as perman...

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Autores principales:	Patrick Krauss, Konstantin Tziridis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1eb777368434668965e261f72ace022
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spelling	oai:doaj.org-article:f1eb777368434668965e261f72ace0222021-12-02T16:17:21ZSimulated transient hearing loss improves auditory sensitivity10.1038/s41598-021-94429-52045-2322https://doaj.org/article/f1eb777368434668965e261f72ace0222021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94429-5https://doaj.org/toc/2045-2322Abstract Recently, it was proposed that a processing principle called adaptive stochastic resonance plays a major role in the auditory system, and serves to maintain optimal sensitivity even to highly variable sound pressure levels. As a side effect, in case of reduced auditory input, such as permanent hearing loss or frequency specific deprivation, this mechanism may eventually lead to the perception of phantom sounds like tinnitus or the Zwicker tone illusion. Using computational modeling, the biological plausibility of this processing principle was already demonstrated. Here, we provide experimental results that further support the stochastic resonance model of auditory perception. In particular, Mongolian gerbils were exposed to moderate intensity, non-damaging long-term notched noise, which mimics hearing loss for frequencies within the notch. Remarkably, the animals developed significantly increased sensitivity, i.e. improved hearing thresholds, for the frequency centered within the notch, but not for frequencies outside the notch. In addition, most animals treated with the new paradigm showed identical behavioral signs of phantom sound perception (tinnitus) as animals with acoustic trauma induced tinnitus. In contrast, animals treated with broadband noise as a control condition did not show any significant threshold change, nor behavioral signs of phantom sound perception.Patrick KraussKonstantin TziridisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrick Krauss Konstantin Tziridis Simulated transient hearing loss improves auditory sensitivity
description	Abstract Recently, it was proposed that a processing principle called adaptive stochastic resonance plays a major role in the auditory system, and serves to maintain optimal sensitivity even to highly variable sound pressure levels. As a side effect, in case of reduced auditory input, such as permanent hearing loss or frequency specific deprivation, this mechanism may eventually lead to the perception of phantom sounds like tinnitus or the Zwicker tone illusion. Using computational modeling, the biological plausibility of this processing principle was already demonstrated. Here, we provide experimental results that further support the stochastic resonance model of auditory perception. In particular, Mongolian gerbils were exposed to moderate intensity, non-damaging long-term notched noise, which mimics hearing loss for frequencies within the notch. Remarkably, the animals developed significantly increased sensitivity, i.e. improved hearing thresholds, for the frequency centered within the notch, but not for frequencies outside the notch. In addition, most animals treated with the new paradigm showed identical behavioral signs of phantom sound perception (tinnitus) as animals with acoustic trauma induced tinnitus. In contrast, animals treated with broadband noise as a control condition did not show any significant threshold change, nor behavioral signs of phantom sound perception.
format	article
author	Patrick Krauss Konstantin Tziridis
author_facet	Patrick Krauss Konstantin Tziridis
author_sort	Patrick Krauss
title	Simulated transient hearing loss improves auditory sensitivity
title_short	Simulated transient hearing loss improves auditory sensitivity
title_full	Simulated transient hearing loss improves auditory sensitivity
title_fullStr	Simulated transient hearing loss improves auditory sensitivity
title_full_unstemmed	Simulated transient hearing loss improves auditory sensitivity
title_sort	simulated transient hearing loss improves auditory sensitivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f1eb777368434668965e261f72ace022
work_keys_str_mv	AT patrickkrauss simulatedtransienthearinglossimprovesauditorysensitivity AT konstantintziridis simulatedtransienthearinglossimprovesauditorysensitivity
_version_	1718384267685265408

Simulated transient hearing loss improves auditory sensitivity

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