Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

Oncolytic viruses (OV) and second mitochondrial activator of caspase (Smac)-mimetic compounds (SMC) synergistically kill cancer cells directly. Here, the authors show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8+ T-cell resp...

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Autores principales:	Dae-Sun Kim, Himika Dastidar, Chunfen Zhang, Franz J. Zemp, Keith Lau, Matthias Ernst, Andrea Rakic, Saif Sikdar, Jahanara Rajwani, Victor Naumenko, Dale R. Balce, Ben W. Ewanchuk, Pankaj Tailor, Robin M. Yates, Craig Jenne, Chris Gafuik, Douglas J. Mahoney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1edf28f5df34c7d87c29319c84877f7
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spelling	oai:doaj.org-article:f1edf28f5df34c7d87c29319c84877f72021-12-02T15:38:51ZSmac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms10.1038/s41467-017-00324-x2041-1723https://doaj.org/article/f1edf28f5df34c7d87c29319c84877f72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00324-xhttps://doaj.org/toc/2041-1723Oncolytic viruses (OV) and second mitochondrial activator of caspase (Smac)-mimetic compounds (SMC) synergistically kill cancer cells directly. Here, the authors show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8+ T-cell response.Dae-Sun KimHimika DastidarChunfen ZhangFranz J. ZempKeith LauMatthias ErnstAndrea RakicSaif SikdarJahanara RajwaniVictor NaumenkoDale R. BalceBen W. EwanchukPankaj TailorRobin M. YatesCraig JenneChris GafuikDouglas J. MahoneyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dae-Sun Kim Himika Dastidar Chunfen Zhang Franz J. Zemp Keith Lau Matthias Ernst Andrea Rakic Saif Sikdar Jahanara Rajwani Victor Naumenko Dale R. Balce Ben W. Ewanchuk Pankaj Tailor Robin M. Yates Craig Jenne Chris Gafuik Douglas J. Mahoney Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
description	Oncolytic viruses (OV) and second mitochondrial activator of caspase (Smac)-mimetic compounds (SMC) synergistically kill cancer cells directly. Here, the authors show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8+ T-cell response.
format	article
author	Dae-Sun Kim Himika Dastidar Chunfen Zhang Franz J. Zemp Keith Lau Matthias Ernst Andrea Rakic Saif Sikdar Jahanara Rajwani Victor Naumenko Dale R. Balce Ben W. Ewanchuk Pankaj Tailor Robin M. Yates Craig Jenne Chris Gafuik Douglas J. Mahoney
author_facet	Dae-Sun Kim Himika Dastidar Chunfen Zhang Franz J. Zemp Keith Lau Matthias Ernst Andrea Rakic Saif Sikdar Jahanara Rajwani Victor Naumenko Dale R. Balce Ben W. Ewanchuk Pankaj Tailor Robin M. Yates Craig Jenne Chris Gafuik Douglas J. Mahoney
author_sort	Dae-Sun Kim
title	Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
title_short	Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
title_full	Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
title_fullStr	Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
title_full_unstemmed	Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
title_sort	smac mimetics and oncolytic viruses synergize in driving anticancer t-cell responses through complementary mechanisms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f1edf28f5df34c7d87c29319c84877f7
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Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

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