Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

Oncolytic viruses (OV) and second mitochondrial activator of caspase (Smac)-mimetic compounds (SMC) synergistically kill cancer cells directly. Here, the authors show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8+ T-cell resp...

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Main Authors: Dae-Sun Kim, Himika Dastidar, Chunfen Zhang, Franz J. Zemp, Keith Lau, Matthias Ernst, Andrea Rakic, Saif Sikdar, Jahanara Rajwani, Victor Naumenko, Dale R. Balce, Ben W. Ewanchuk, Pankaj Tailor, Robin M. Yates, Craig Jenne, Chris Gafuik, Douglas J. Mahoney
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/f1edf28f5df34c7d87c29319c84877f7
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https://doaj.org/article/f1edf28f5df34c7d87c29319c84877f7

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