Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories

Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories

Misfolding of superoxide dismutase 1 (SOD1) is linked to amyotrophic lateral sclerosis. Here the authors characterize the unfolding/refolding of single SOD1 molecules using optical tweezers, identifying partially folded intermediates that lead to misfolding after the formation of a native-like core.

Guardado en:
Detalles Bibliográficos
Autores principales: Supratik Sen Mojumdar, Zackary N. Scholl, Derek R. Dee, Logan Rouleau, Uttam Anand, Craig Garen, Michael T. Woodside
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f1f068ff3345441b973c4a6b29d464b1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f1f068ff3345441b973c4a6b29d464b1
record_format dspace
spelling oai:doaj.org-article:f1f068ff3345441b973c4a6b29d464b12021-12-02T17:06:00ZPartially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories10.1038/s41467-017-01996-12041-1723https://doaj.org/article/f1f068ff3345441b973c4a6b29d464b12017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01996-1https://doaj.org/toc/2041-1723Misfolding of superoxide dismutase 1 (SOD1) is linked to amyotrophic lateral sclerosis. Here the authors characterize the unfolding/refolding of single SOD1 molecules using optical tweezers, identifying partially folded intermediates that lead to misfolding after the formation of a native-like core.Supratik Sen MojumdarZackary N. SchollDerek R. DeeLogan RouleauUttam AnandCraig GarenMichael T. WoodsideNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Supratik Sen Mojumdar
Zackary N. Scholl
Derek R. Dee
Logan Rouleau
Uttam Anand
Craig Garen
Michael T. Woodside
Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories
description Misfolding of superoxide dismutase 1 (SOD1) is linked to amyotrophic lateral sclerosis. Here the authors characterize the unfolding/refolding of single SOD1 molecules using optical tweezers, identifying partially folded intermediates that lead to misfolding after the formation of a native-like core.
format article
author Supratik Sen Mojumdar
Zackary N. Scholl
Derek R. Dee
Logan Rouleau
Uttam Anand
Craig Garen
Michael T. Woodside
author_facet Supratik Sen Mojumdar
Zackary N. Scholl
Derek R. Dee
Logan Rouleau
Uttam Anand
Craig Garen
Michael T. Woodside
author_sort Supratik Sen Mojumdar
title Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories
title_short Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories
title_full Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories
title_fullStr Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories
title_full_unstemmed Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories
title_sort partially native intermediates mediate misfolding of sod1 in single-molecule folding trajectories
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/f1f068ff3345441b973c4a6b29d464b1
work_keys_str_mv AT supratiksenmojumdar partiallynativeintermediatesmediatemisfoldingofsod1insinglemoleculefoldingtrajectories
AT zackarynscholl partiallynativeintermediatesmediatemisfoldingofsod1insinglemoleculefoldingtrajectories
AT derekrdee partiallynativeintermediatesmediatemisfoldingofsod1insinglemoleculefoldingtrajectories
AT loganrouleau partiallynativeintermediatesmediatemisfoldingofsod1insinglemoleculefoldingtrajectories
AT uttamanand partiallynativeintermediatesmediatemisfoldingofsod1insinglemoleculefoldingtrajectories
AT craiggaren partiallynativeintermediatesmediatemisfoldingofsod1insinglemoleculefoldingtrajectories
AT michaeltwoodside partiallynativeintermediatesmediatemisfoldingofsod1insinglemoleculefoldingtrajectories
_version_ 1718381768308948992

Ejemplares similares