Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults
Fangjie Zhan,1 Jin Chen,1 Huihui Yan,1 Shuiliang Wang,1 Meng Zhao,1 Shenghang Zhang,1 Xiaopeng Lan,1 Masato Maekawa2 1Department of Clinical Laboratory Medicine, The 900th Hospital of Joint Logistics Support Force, Fuzhou, People’s Republic of China; 2Department of Laboratory Medicine, Hamamatsu Uni...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2021
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| Acceso en línea: | https://doaj.org/article/f1f0dd0285bf498aa4f674983323855b |
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| Sumario: | Fangjie Zhan,1 Jin Chen,1 Huihui Yan,1 Shuiliang Wang,1 Meng Zhao,1 Shenghang Zhang,1 Xiaopeng Lan,1 Masato Maekawa2 1Department of Clinical Laboratory Medicine, The 900th Hospital of Joint Logistics Support Force, Fuzhou, People’s Republic of China; 2Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanCorrespondence: Xiaopeng LanDepartment of Clinical Laboratory Medicine, The 900th Hospital of Joint Logistics Support Force, 156th, Xierhuan Road, Fuzhou, 350025, People’s Republic of ChinaTel +86 591 22859482Email lanxp@sina.comMasato MaekawaDepartment of Laboratory Medicine, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, 431-3192, JapanTel +81-53-435-2721Fax +81-53-435-2096Email mmaekawa@hama-med.ac.jpPurpose: Low serum amylase activity and copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) are reportedly associated with obesity and abnormal glucose metabolism; however, this association remains controversial. We aimed to clarify the relationship between serum amylase activity and the CNV of AMY1/2A/2B with the occurrence of metabolic syndrome (MetS) in Chinese adults.Patients and Methods: Anthropometry, metabolic risk factors, and serum amylase activity were assessed in 560 subjects (260 MetS patients; 300 healthy controls). AMY1/2A/2B CNs were evaluated using the highly sensitive droplet digital PCR.Results: The serum total, pancreatic, and salivary amylase activity, but not the AMY1/2A/2B CNs, was significantly lower in MetS patients than that in the control subjects. Patients < 45 y had a lower AMY1 CN, compared to that in healthy controls. Low serum amylase activity was significantly associated with high MetS prevalence (p < 0.001). In the receiver operating characteristic curve analysis, serum amylase activity was a significant diagnostic indicator for MetS. The diagnostic value of total amylase was second only to that of γ-glutamyl transpeptidase; it was higher than that of alanine aminotransferase and uric acid.Conclusion: Low serum amylase activity was significantly associated with increased risk of MetS in Chinese adults. Therefore, amylase could be a potential biomarker for predicting MetS.Keywords: amylase, copy number variation, metabolic disorders, biomarker, Chinese population |
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