Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults

Fangjie Zhan,1 Jin Chen,1 Huihui Yan,1 Shuiliang Wang,1 Meng Zhao,1 Shenghang Zhang,1 Xiaopeng Lan,1 Masato Maekawa2 1Department of Clinical Laboratory Medicine, The 900th Hospital of Joint Logistics Support Force, Fuzhou, People’s Republic of China; 2Department of Laboratory Medicine, Hamamatsu Uni...

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Autores principales:	Zhan F, Chen J, Yan H, Wang S, Zhao M, Zhang S, Lan X, Maekawa M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	amylase copy number variation metabolic disorders biomarker chinese population Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/f1f0dd0285bf498aa4f674983323855b
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spelling	oai:doaj.org-article:f1f0dd0285bf498aa4f674983323855b2021-12-02T19:17:36ZAssociation of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults1178-7007https://doaj.org/article/f1f0dd0285bf498aa4f674983323855b2021-12-01T00:00:00Zhttps://www.dovepress.com/association-of-serum-amylase-activity-and-the-copy-number-variation-of-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Fangjie Zhan,1 Jin Chen,1 Huihui Yan,1 Shuiliang Wang,1 Meng Zhao,1 Shenghang Zhang,1 Xiaopeng Lan,1 Masato Maekawa2 1Department of Clinical Laboratory Medicine, The 900th Hospital of Joint Logistics Support Force, Fuzhou, People’s Republic of China; 2Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanCorrespondence: Xiaopeng LanDepartment of Clinical Laboratory Medicine, The 900th Hospital of Joint Logistics Support Force, 156th, Xierhuan Road, Fuzhou, 350025, People’s Republic of ChinaTel +86 591 22859482Email lanxp@sina.comMasato MaekawaDepartment of Laboratory Medicine, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, 431-3192, JapanTel +81-53-435-2721Fax +81-53-435-2096Email mmaekawa@hama-med.ac.jpPurpose: Low serum amylase activity and copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) are reportedly associated with obesity and abnormal glucose metabolism; however, this association remains controversial. We aimed to clarify the relationship between serum amylase activity and the CNV of AMY1/2A/2B with the occurrence of metabolic syndrome (MetS) in Chinese adults.Patients and Methods: Anthropometry, metabolic risk factors, and serum amylase activity were assessed in 560 subjects (260 MetS patients; 300 healthy controls). AMY1/2A/2B CNs were evaluated using the highly sensitive droplet digital PCR.Results: The serum total, pancreatic, and salivary amylase activity, but not the AMY1/2A/2B CNs, was significantly lower in MetS patients than that in the control subjects. Patients < 45 y had a lower AMY1 CN, compared to that in healthy controls. Low serum amylase activity was significantly associated with high MetS prevalence (p < 0.001). In the receiver operating characteristic curve analysis, serum amylase activity was a significant diagnostic indicator for MetS. The diagnostic value of total amylase was second only to that of γ-glutamyl transpeptidase; it was higher than that of alanine aminotransferase and uric acid.Conclusion: Low serum amylase activity was significantly associated with increased risk of MetS in Chinese adults. Therefore, amylase could be a potential biomarker for predicting MetS.Keywords: amylase, copy number variation, metabolic disorders, biomarker, Chinese populationZhan FChen JYan HWang SZhao MZhang SLan XMaekawa MDove Medical Pressarticleamylasecopy number variationmetabolic disordersbiomarkerchinese populationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4705-4714 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amylase copy number variation metabolic disorders biomarker chinese population Specialties of internal medicine RC581-951
spellingShingle	amylase copy number variation metabolic disorders biomarker chinese population Specialties of internal medicine RC581-951 Zhan F Chen J Yan H Wang S Zhao M Zhang S Lan X Maekawa M Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults
description	Fangjie Zhan,1 Jin Chen,1 Huihui Yan,1 Shuiliang Wang,1 Meng Zhao,1 Shenghang Zhang,1 Xiaopeng Lan,1 Masato Maekawa2 1Department of Clinical Laboratory Medicine, The 900th Hospital of Joint Logistics Support Force, Fuzhou, People’s Republic of China; 2Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanCorrespondence: Xiaopeng LanDepartment of Clinical Laboratory Medicine, The 900th Hospital of Joint Logistics Support Force, 156th, Xierhuan Road, Fuzhou, 350025, People’s Republic of ChinaTel +86 591 22859482Email lanxp@sina.comMasato MaekawaDepartment of Laboratory Medicine, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, 431-3192, JapanTel +81-53-435-2721Fax +81-53-435-2096Email mmaekawa@hama-med.ac.jpPurpose: Low serum amylase activity and copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) are reportedly associated with obesity and abnormal glucose metabolism; however, this association remains controversial. We aimed to clarify the relationship between serum amylase activity and the CNV of AMY1/2A/2B with the occurrence of metabolic syndrome (MetS) in Chinese adults.Patients and Methods: Anthropometry, metabolic risk factors, and serum amylase activity were assessed in 560 subjects (260 MetS patients; 300 healthy controls). AMY1/2A/2B CNs were evaluated using the highly sensitive droplet digital PCR.Results: The serum total, pancreatic, and salivary amylase activity, but not the AMY1/2A/2B CNs, was significantly lower in MetS patients than that in the control subjects. Patients < 45 y had a lower AMY1 CN, compared to that in healthy controls. Low serum amylase activity was significantly associated with high MetS prevalence (p < 0.001). In the receiver operating characteristic curve analysis, serum amylase activity was a significant diagnostic indicator for MetS. The diagnostic value of total amylase was second only to that of γ-glutamyl transpeptidase; it was higher than that of alanine aminotransferase and uric acid.Conclusion: Low serum amylase activity was significantly associated with increased risk of MetS in Chinese adults. Therefore, amylase could be a potential biomarker for predicting MetS.Keywords: amylase, copy number variation, metabolic disorders, biomarker, Chinese population
format	article
author	Zhan F Chen J Yan H Wang S Zhao M Zhang S Lan X Maekawa M
author_facet	Zhan F Chen J Yan H Wang S Zhao M Zhang S Lan X Maekawa M
author_sort	Zhan F
title	Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults
title_short	Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults
title_full	Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults
title_fullStr	Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults
title_full_unstemmed	Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults
title_sort	association of serum amylase activity and the copy number variation of amy1/2a/2b with metabolic syndrome in chinese adults
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f1f0dd0285bf498aa4f674983323855b
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Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults

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