Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.
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Nature Portfolio
2016
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oai:doaj.org-article:f1f19a27cbc7439a93582c5ddb593cd12021-12-02T16:56:46ZHyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells10.1038/ncomms134962041-1723https://doaj.org/article/f1f19a27cbc7439a93582c5ddb593cd12016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13496https://doaj.org/toc/2041-1723Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.Melissa F. BreretonMaria RohmKenju ShimomuraChristian HollandSharona Tornovsky-BabeayDaniela DadonMichaela IberlMargarita V. ChibalinaSheena LeeBenjamin GlaserYuval DorPatrik RorsmanAnne ClarkFrances M. AshcroftNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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DOAJ |
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EN |
topic |
Science Q |
spellingShingle |
Science Q Melissa F. Brereton Maria Rohm Kenju Shimomura Christian Holland Sharona Tornovsky-Babeay Daniela Dadon Michaela Iberl Margarita V. Chibalina Sheena Lee Benjamin Glaser Yuval Dor Patrik Rorsman Anne Clark Frances M. Ashcroft Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells |
description |
Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis. |
format |
article |
author |
Melissa F. Brereton Maria Rohm Kenju Shimomura Christian Holland Sharona Tornovsky-Babeay Daniela Dadon Michaela Iberl Margarita V. Chibalina Sheena Lee Benjamin Glaser Yuval Dor Patrik Rorsman Anne Clark Frances M. Ashcroft |
author_facet |
Melissa F. Brereton Maria Rohm Kenju Shimomura Christian Holland Sharona Tornovsky-Babeay Daniela Dadon Michaela Iberl Margarita V. Chibalina Sheena Lee Benjamin Glaser Yuval Dor Patrik Rorsman Anne Clark Frances M. Ashcroft |
author_sort |
Melissa F. Brereton |
title |
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells |
title_short |
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells |
title_full |
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells |
title_fullStr |
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells |
title_full_unstemmed |
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells |
title_sort |
hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/f1f19a27cbc7439a93582c5ddb593cd1 |
work_keys_str_mv |
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