Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.

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Détails bibliographiques
Auteurs principaux:	Melissa F. Brereton, Maria Rohm, Kenju Shimomura, Christian Holland, Sharona Tornovsky-Babeay, Daniela Dadon, Michaela Iberl, Margarita V. Chibalina, Sheena Lee, Benjamin Glaser, Yuval Dor, Patrik Rorsman, Anne Clark, Frances M. Ashcroft
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f1f19a27cbc7439a93582c5ddb593cd1
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spelling	oai:doaj.org-article:f1f19a27cbc7439a93582c5ddb593cd12021-12-02T16:56:46ZHyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells10.1038/ncomms134962041-1723https://doaj.org/article/f1f19a27cbc7439a93582c5ddb593cd12016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13496https://doaj.org/toc/2041-1723Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.Melissa F. BreretonMaria RohmKenju ShimomuraChristian HollandSharona Tornovsky-BabeayDaniela DadonMichaela IberlMargarita V. ChibalinaSheena LeeBenjamin GlaserYuval DorPatrik RorsmanAnne ClarkFrances M. AshcroftNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melissa F. Brereton Maria Rohm Kenju Shimomura Christian Holland Sharona Tornovsky-Babeay Daniela Dadon Michaela Iberl Margarita V. Chibalina Sheena Lee Benjamin Glaser Yuval Dor Patrik Rorsman Anne Clark Frances M. Ashcroft Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
description	Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.
format	article
author	Melissa F. Brereton Maria Rohm Kenju Shimomura Christian Holland Sharona Tornovsky-Babeay Daniela Dadon Michaela Iberl Margarita V. Chibalina Sheena Lee Benjamin Glaser Yuval Dor Patrik Rorsman Anne Clark Frances M. Ashcroft
author_facet	Melissa F. Brereton Maria Rohm Kenju Shimomura Christian Holland Sharona Tornovsky-Babeay Daniela Dadon Michaela Iberl Margarita V. Chibalina Sheena Lee Benjamin Glaser Yuval Dor Patrik Rorsman Anne Clark Frances M. Ashcroft
author_sort	Melissa F. Brereton
title	Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
title_short	Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
title_full	Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
title_fullStr	Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
title_full_unstemmed	Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
title_sort	hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f1f19a27cbc7439a93582c5ddb593cd1
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Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

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