Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes

Objective: One of the treatment goals in type 1 diabetes and periodontitis is to address chronic inflammation to prevent the development of neurovascular complications. The aim of this study was to assess the local anti-inflammatory effects of chlorhexidine digluconate and cetylpyridine chloride on...

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Autores principales:	Jakub Lipski, Anna Duda-Sobczak, Marta Napierala, Ewa Florek, Dorota Zozulinska-Ziolkiewicz, Marzena Wyganowska-Swiatkowska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chlorhexidine digluconate cetylpyridine chloride oxidative stress type 1 diabetes Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f1f40d4220d54da2b0fb68a538dfffff
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spelling	oai:doaj.org-article:f1f40d4220d54da2b0fb68a538dfffff2021-11-25T16:27:24ZInfluence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes10.3390/antiox101117322076-3921https://doaj.org/article/f1f40d4220d54da2b0fb68a538dfffff2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1732https://doaj.org/toc/2076-3921Objective: One of the treatment goals in type 1 diabetes and periodontitis is to address chronic inflammation to prevent the development of neurovascular complications. The aim of this study was to assess the local anti-inflammatory effects of chlorhexidine digluconate and cetylpyridine chloride on periodontal status and indicators of oxidative stress in saliva in patients with type 1 diabetes. Materials and Methods: A total of 42 subjects aged 27 (interquartile range, IQR 22–35) years, with type 1 diabetes for a duration of 12 (IQR 9–18) years, and glycated hemoglobin 8.05 (IQR 7.1–9.4)% were included. Patients were examined twice—initially, and after 14 days of using toothpaste with chlorhexidine and cetylpyridine. Clinical examination of gingival tissues was performed. Certain oxidative stress markers (TP, TEAC, TBARS, AOPP) were measured in the saliva samples. Results: There were significant changes in clinical indicators of periodontal status before and after the application of the toothpaste (API before 0.35 (0.24–0.65) vs. API after 0.265 (0.18–0.39), <i>p</i> = 0.03; SBI before 0.07 (0.04–0.15) vs. SBI after 0.035 (0-0.06), <i>p</i> = 0.002; GI before 0.88 (0.46–1) vs. GI after 0.67 (0.25–1), <i>p</i> = 0.0008). The concentration of saliva TBARS decreased (<i>p</i> = 0.00005) and TEAC increased (<i>p</i> = 0.09). Conclusion: Proper oral hygiene supported by antibacterial chemicals may improve the periodontal status and reduce inflammation.Jakub LipskiAnna Duda-SobczakMarta NapieralaEwa FlorekDorota Zozulinska-ZiolkiewiczMarzena Wyganowska-SwiatkowskaMDPI AGarticlechlorhexidine digluconatecetylpyridine chlorideoxidative stresstype 1 diabetesTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1732, p 1732 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chlorhexidine digluconate cetylpyridine chloride oxidative stress type 1 diabetes Therapeutics. Pharmacology RM1-950
spellingShingle	chlorhexidine digluconate cetylpyridine chloride oxidative stress type 1 diabetes Therapeutics. Pharmacology RM1-950 Jakub Lipski Anna Duda-Sobczak Marta Napierala Ewa Florek Dorota Zozulinska-Ziolkiewicz Marzena Wyganowska-Swiatkowska Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes
description	Objective: One of the treatment goals in type 1 diabetes and periodontitis is to address chronic inflammation to prevent the development of neurovascular complications. The aim of this study was to assess the local anti-inflammatory effects of chlorhexidine digluconate and cetylpyridine chloride on periodontal status and indicators of oxidative stress in saliva in patients with type 1 diabetes. Materials and Methods: A total of 42 subjects aged 27 (interquartile range, IQR 22–35) years, with type 1 diabetes for a duration of 12 (IQR 9–18) years, and glycated hemoglobin 8.05 (IQR 7.1–9.4)% were included. Patients were examined twice—initially, and after 14 days of using toothpaste with chlorhexidine and cetylpyridine. Clinical examination of gingival tissues was performed. Certain oxidative stress markers (TP, TEAC, TBARS, AOPP) were measured in the saliva samples. Results: There were significant changes in clinical indicators of periodontal status before and after the application of the toothpaste (API before 0.35 (0.24–0.65) vs. API after 0.265 (0.18–0.39), <i>p</i> = 0.03; SBI before 0.07 (0.04–0.15) vs. SBI after 0.035 (0-0.06), <i>p</i> = 0.002; GI before 0.88 (0.46–1) vs. GI after 0.67 (0.25–1), <i>p</i> = 0.0008). The concentration of saliva TBARS decreased (<i>p</i> = 0.00005) and TEAC increased (<i>p</i> = 0.09). Conclusion: Proper oral hygiene supported by antibacterial chemicals may improve the periodontal status and reduce inflammation.
format	article
author	Jakub Lipski Anna Duda-Sobczak Marta Napierala Ewa Florek Dorota Zozulinska-Ziolkiewicz Marzena Wyganowska-Swiatkowska
author_facet	Jakub Lipski Anna Duda-Sobczak Marta Napierala Ewa Florek Dorota Zozulinska-Ziolkiewicz Marzena Wyganowska-Swiatkowska
author_sort	Jakub Lipski
title	Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes
title_short	Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes
title_full	Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes
title_fullStr	Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes
title_full_unstemmed	Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes
title_sort	influence of chlorhexidine and cetylpyridine on periodontal status and indicators of oxidative stress in patients with type 1 diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f1f40d4220d54da2b0fb68a538dfffff
work_keys_str_mv	AT jakublipski influenceofchlorhexidineandcetylpyridineonperiodontalstatusandindicatorsofoxidativestressinpatientswithtype1diabetes AT annadudasobczak influenceofchlorhexidineandcetylpyridineonperiodontalstatusandindicatorsofoxidativestressinpatientswithtype1diabetes AT martanapierala influenceofchlorhexidineandcetylpyridineonperiodontalstatusandindicatorsofoxidativestressinpatientswithtype1diabetes AT ewaflorek influenceofchlorhexidineandcetylpyridineonperiodontalstatusandindicatorsofoxidativestressinpatientswithtype1diabetes AT dorotazozulinskaziolkiewicz influenceofchlorhexidineandcetylpyridineonperiodontalstatusandindicatorsofoxidativestressinpatientswithtype1diabetes AT marzenawyganowskaswiatkowska influenceofchlorhexidineandcetylpyridineonperiodontalstatusandindicatorsofoxidativestressinpatientswithtype1diabetes
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Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes

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