Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report

Untreated individuals with antithrombin (AT) deficiency are at higher risk of thrombosis and adverse pregnancy outcomes. The present recommendations are mostly empirical for treating patients with AT deficiency during pregnancy because of the absence of guidelines. We report a rare case of heparin r...

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Autores principales:	Xiaoxin Zhang, Feng Guo, Qiaohong Wang, Wenxin Bai, Aimin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f1f5bf11e3134d629755e0476e98d6d8
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spelling	oai:doaj.org-article:f1f5bf11e3134d629755e0476e98d6d82021-12-02T08:04:02ZManagement of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report1473-230010.1177/03000605211058355https://doaj.org/article/f1f5bf11e3134d629755e0476e98d6d82021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211058355https://doaj.org/toc/1473-2300Untreated individuals with antithrombin (AT) deficiency are at higher risk of thrombosis and adverse pregnancy outcomes. The present recommendations are mostly empirical for treating patients with AT deficiency during pregnancy because of the absence of guidelines. We report a rare case of heparin resistance due to AT deficiency in a pregnant 32-year-old Chinese woman. We also reviewed the English medical literature for AT deficiency and its association with thromboembolism and treatment. This patient suffered two early miscarriages because of thrombosis due to AT deficiency. The patient was administered the combination of adequate low molecular weight heparin with fresh frozen plasma and warfarin because of her heparin resistance. She delivered a healthy female newborn without any adverse effects of the anticoagulation therapy. Our findings suggest that the combination of adequate low molecular weight heparin with fresh frozen plasma and warfarin is effective for preventing thrombus during pregnancy.Xiaoxin ZhangFeng GuoQiaohong WangWenxin BaiAimin ZhaoSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiaoxin Zhang Feng Guo Qiaohong Wang Wenxin Bai Aimin Zhao Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report
description	Untreated individuals with antithrombin (AT) deficiency are at higher risk of thrombosis and adverse pregnancy outcomes. The present recommendations are mostly empirical for treating patients with AT deficiency during pregnancy because of the absence of guidelines. We report a rare case of heparin resistance due to AT deficiency in a pregnant 32-year-old Chinese woman. We also reviewed the English medical literature for AT deficiency and its association with thromboembolism and treatment. This patient suffered two early miscarriages because of thrombosis due to AT deficiency. The patient was administered the combination of adequate low molecular weight heparin with fresh frozen plasma and warfarin because of her heparin resistance. She delivered a healthy female newborn without any adverse effects of the anticoagulation therapy. Our findings suggest that the combination of adequate low molecular weight heparin with fresh frozen plasma and warfarin is effective for preventing thrombus during pregnancy.
format	article
author	Xiaoxin Zhang Feng Guo Qiaohong Wang Wenxin Bai Aimin Zhao
author_facet	Xiaoxin Zhang Feng Guo Qiaohong Wang Wenxin Bai Aimin Zhao
author_sort	Xiaoxin Zhang
title	Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report
title_short	Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report
title_full	Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report
title_fullStr	Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report
title_full_unstemmed	Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report
title_sort	management of heparin resistance due to antithrombin deficiency in a chinese pregnant woman: a case report
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/f1f5bf11e3134d629755e0476e98d6d8
work_keys_str_mv	AT xiaoxinzhang managementofheparinresistanceduetoantithrombindeficiencyinachinesepregnantwomanacasereport AT fengguo managementofheparinresistanceduetoantithrombindeficiencyinachinesepregnantwomanacasereport AT qiaohongwang managementofheparinresistanceduetoantithrombindeficiencyinachinesepregnantwomanacasereport AT wenxinbai managementofheparinresistanceduetoantithrombindeficiencyinachinesepregnantwomanacasereport AT aiminzhao managementofheparinresistanceduetoantithrombindeficiencyinachinesepregnantwomanacasereport
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Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report

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