Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

Abstract We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy,...

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Autores principales:	José C. Páez-Franco, Jiram Torres-Ruiz, Víctor A. Sosa-Hernández, Rodrigo Cervantes-Díaz, Sandra Romero-Ramírez, Alfredo Pérez-Fragoso, David E. Meza-Sánchez, Juan Manuel Germán-Acacio, José L. Maravillas-Montero, Nancy R. Mejía-Domínguez, Alfredo Ponce-de-León, Alfredo Ulloa-Aguirre, Diana Gómez-Martín, Luis Llorente
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2049ab772c343f592bbd0ee9b7ddc09
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spelling	oai:doaj.org-article:f2049ab772c343f592bbd0ee9b7ddc092021-12-02T17:04:59ZMetabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients10.1038/s41598-021-85788-02045-2322https://doaj.org/article/f2049ab772c343f592bbd0ee9b7ddc092021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85788-0https://doaj.org/toc/2045-2322Abstract We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.José C. Páez-FrancoJiram Torres-RuizVíctor A. Sosa-HernándezRodrigo Cervantes-DíazSandra Romero-RamírezAlfredo Pérez-FragosoDavid E. Meza-SánchezJuan Manuel Germán-AcacioJosé L. Maravillas-MonteroNancy R. Mejía-DomínguezAlfredo Ponce-de-LeónAlfredo Ulloa-AguirreDiana Gómez-MartínLuis LlorenteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José C. Páez-Franco Jiram Torres-Ruiz Víctor A. Sosa-Hernández Rodrigo Cervantes-Díaz Sandra Romero-Ramírez Alfredo Pérez-Fragoso David E. Meza-Sánchez Juan Manuel Germán-Acacio José L. Maravillas-Montero Nancy R. Mejía-Domínguez Alfredo Ponce-de-León Alfredo Ulloa-Aguirre Diana Gómez-Martín Luis Llorente Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
description	Abstract We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.
format	article
author	José C. Páez-Franco Jiram Torres-Ruiz Víctor A. Sosa-Hernández Rodrigo Cervantes-Díaz Sandra Romero-Ramírez Alfredo Pérez-Fragoso David E. Meza-Sánchez Juan Manuel Germán-Acacio José L. Maravillas-Montero Nancy R. Mejía-Domínguez Alfredo Ponce-de-León Alfredo Ulloa-Aguirre Diana Gómez-Martín Luis Llorente
author_facet	José C. Páez-Franco Jiram Torres-Ruiz Víctor A. Sosa-Hernández Rodrigo Cervantes-Díaz Sandra Romero-Ramírez Alfredo Pérez-Fragoso David E. Meza-Sánchez Juan Manuel Germán-Acacio José L. Maravillas-Montero Nancy R. Mejía-Domínguez Alfredo Ponce-de-León Alfredo Ulloa-Aguirre Diana Gómez-Martín Luis Llorente
author_sort	José C. Páez-Franco
title	Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
title_short	Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
title_full	Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
title_fullStr	Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
title_full_unstemmed	Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
title_sort	metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in covid-19 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2049ab772c343f592bbd0ee9b7ddc09
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Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

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