Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology. Here, the authors investigated whether plasma ptau181 could be a potential biomarker of AD in individuals with Down syndrome (DS) and find plasma p-tau181 can detect AD in DS adults.
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Nature Portfolio
2021
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oai:doaj.org-article:f20567ee748b4d4a827bf092f51326082021-12-02T16:08:13ZPhosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome10.1038/s41467-021-24319-x2041-1723https://doaj.org/article/f20567ee748b4d4a827bf092f51326082021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24319-xhttps://doaj.org/toc/2041-1723Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology. Here, the authors investigated whether plasma ptau181 could be a potential biomarker of AD in individuals with Down syndrome (DS) and find plasma p-tau181 can detect AD in DS adults.Alberto LleóHenrik ZetterbergJordi PeguerolesThomas K. KarikariMaría Carmona-IraguiNicholas J. AshtonVictor MontalIsabel BarroetaJuan Lantero-RodríguezLaura VidelaMiren AltunaBessy BenejamSusana FernandezSilvia ValldeneuDiana GarzónAlexandre BejaninMaria Florencia IulitaValle CamachoSantiago Medrano-MartorellOlivia BelbinJordi ClarimonSylvain LehmannDaniel AlcoleaRafael BlesaKaj BlennowJuan ForteaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021) |
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Science Q Alberto Lleó Henrik Zetterberg Jordi Pegueroles Thomas K. Karikari María Carmona-Iragui Nicholas J. Ashton Victor Montal Isabel Barroeta Juan Lantero-Rodríguez Laura Videla Miren Altuna Bessy Benejam Susana Fernandez Silvia Valldeneu Diana Garzón Alexandre Bejanin Maria Florencia Iulita Valle Camacho Santiago Medrano-Martorell Olivia Belbin Jordi Clarimon Sylvain Lehmann Daniel Alcolea Rafael Blesa Kaj Blennow Juan Fortea Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome |
| description |
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology. Here, the authors investigated whether plasma ptau181 could be a potential biomarker of AD in individuals with Down syndrome (DS) and find plasma p-tau181 can detect AD in DS adults. |
| format |
article |
| author |
Alberto Lleó Henrik Zetterberg Jordi Pegueroles Thomas K. Karikari María Carmona-Iragui Nicholas J. Ashton Victor Montal Isabel Barroeta Juan Lantero-Rodríguez Laura Videla Miren Altuna Bessy Benejam Susana Fernandez Silvia Valldeneu Diana Garzón Alexandre Bejanin Maria Florencia Iulita Valle Camacho Santiago Medrano-Martorell Olivia Belbin Jordi Clarimon Sylvain Lehmann Daniel Alcolea Rafael Blesa Kaj Blennow Juan Fortea |
| author_facet |
Alberto Lleó Henrik Zetterberg Jordi Pegueroles Thomas K. Karikari María Carmona-Iragui Nicholas J. Ashton Victor Montal Isabel Barroeta Juan Lantero-Rodríguez Laura Videla Miren Altuna Bessy Benejam Susana Fernandez Silvia Valldeneu Diana Garzón Alexandre Bejanin Maria Florencia Iulita Valle Camacho Santiago Medrano-Martorell Olivia Belbin Jordi Clarimon Sylvain Lehmann Daniel Alcolea Rafael Blesa Kaj Blennow Juan Fortea |
| author_sort |
Alberto Lleó |
| title |
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome |
| title_short |
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome |
| title_full |
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome |
| title_fullStr |
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome |
| title_full_unstemmed |
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome |
| title_sort |
phosphorylated tau181 in plasma as a potential biomarker for alzheimer’s disease in adults with down syndrome |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/f20567ee748b4d4a827bf092f5132608 |
| work_keys_str_mv |
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