Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome

Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome

Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology. Here, the authors investigated whether plasma ptau181 could be a potential biomarker of AD in individuals with Down syndrome (DS) and find plasma p-tau181 can detect AD in DS adults.

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Autores principales: Alberto Lleó, Henrik Zetterberg, Jordi Pegueroles, Thomas K. Karikari, María Carmona-Iragui, Nicholas J. Ashton, Victor Montal, Isabel Barroeta, Juan Lantero-Rodríguez, Laura Videla, Miren Altuna, Bessy Benejam, Susana Fernandez, Silvia Valldeneu, Diana Garzón, Alexandre Bejanin, Maria Florencia Iulita, Valle Camacho, Santiago Medrano-Martorell, Olivia Belbin, Jordi Clarimon, Sylvain Lehmann, Daniel Alcolea, Rafael Blesa, Kaj Blennow, Juan Fortea
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f20567ee748b4d4a827bf092f5132608
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