Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

Gadolinium(III) complexes are strong enhancers of magnetic resonance imaging (MRI) signals, thus are widely used as contrast agents despite their potential toxicity. Here, the authors review ligand design approaches aimed at improving the stability of Gd(III)-based MRI contrast agents.

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Auteurs principaux:	Thomas J. Clough, Lijun Jiang, Ka-Leung Wong, Nicholas J. Long
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f20637c1e52446f1b3f9afd3a401fc33
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id	oai:doaj.org-article:f20637c1e52446f1b3f9afd3a401fc33
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spelling	oai:doaj.org-article:f20637c1e52446f1b3f9afd3a401fc332021-12-02T17:01:39ZLigand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents10.1038/s41467-019-09342-32041-1723https://doaj.org/article/f20637c1e52446f1b3f9afd3a401fc332019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09342-3https://doaj.org/toc/2041-1723Gadolinium(III) complexes are strong enhancers of magnetic resonance imaging (MRI) signals, thus are widely used as contrast agents despite their potential toxicity. Here, the authors review ligand design approaches aimed at improving the stability of Gd(III)-based MRI contrast agents.Thomas J. CloughLijun JiangKa-Leung WongNicholas J. LongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas J. Clough Lijun Jiang Ka-Leung Wong Nicholas J. Long Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
description	Gadolinium(III) complexes are strong enhancers of magnetic resonance imaging (MRI) signals, thus are widely used as contrast agents despite their potential toxicity. Here, the authors review ligand design approaches aimed at improving the stability of Gd(III)-based MRI contrast agents.
format	article
author	Thomas J. Clough Lijun Jiang Ka-Leung Wong Nicholas J. Long
author_facet	Thomas J. Clough Lijun Jiang Ka-Leung Wong Nicholas J. Long
author_sort	Thomas J. Clough
title	Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
title_short	Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
title_full	Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
title_fullStr	Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
title_full_unstemmed	Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
title_sort	ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f20637c1e52446f1b3f9afd3a401fc33
work_keys_str_mv	AT thomasjclough liganddesignstrategiestoincreasestabilityofgadoliniumbasedmagneticresonanceimagingcontrastagents AT lijunjiang liganddesignstrategiestoincreasestabilityofgadoliniumbasedmagneticresonanceimagingcontrastagents AT kaleungwong liganddesignstrategiestoincreasestabilityofgadoliniumbasedmagneticresonanceimagingcontrastagents AT nicholasjlong liganddesignstrategiestoincreasestabilityofgadoliniumbasedmagneticresonanceimagingcontrastagents
_version_	1718382123064229888

Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

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