Build-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>

Many introductory biology students have a weak (or nonexistent) chemistry background. Due to this apparent knowledge gap, many students struggle to understand the process of polypeptide formation via dehydration synthesis as well as the interactions between individual polypeptide chains. This inabil...

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Autores principales:	Kristi Hall, Jackson Dunitz, Patricia Shields
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Special aspects of education LC8-6691 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f2089e74cc884b8881c6fde896649296
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spelling	oai:doaj.org-article:f2089e74cc884b8881c6fde8966492962021-11-15T15:15:37ZBuild-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>10.1128/jmbe.v15i2.7351935-78851935-7877https://doaj.org/article/f2089e74cc884b8881c6fde8966492962014-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/jmbe.v15i2.735https://doaj.org/toc/1935-7877https://doaj.org/toc/1935-7885Many introductory biology students have a weak (or nonexistent) chemistry background. Due to this apparent knowledge gap, many students struggle to understand the process of polypeptide formation via dehydration synthesis as well as the interactions between individual polypeptide chains. This inability to reason about how individual amino acids interact with one another prevents students from making the cognitive leap from primary to secondary structure. In turn, students do not fully understand how even higher levels of organizations (i.e., tertiary and quaternary interactions) form the final three-dimensional configurations of proteins. We designed Build-a-Polypeptide in an attempt to help fill the part of the knowledge gap. In this activity, students physically represent the process of polypeptide synthesis and R group interactions using a paper model. Essentially, this is a simple cut and paste project that allows students to build a beginner's (i.e., highly truncated and simplified) model of protein folding. Previous research has shown that physical modeling can aid student understanding of complex topics (1,2). With that in mind, we developed this interactive activity to improve student understanding of protein synthesis and structure formation. This activity requires no laboratory equipment and can be completed within one (50 minute) class. Our worksheets were designed for use in introductory college-level biology courses, but could easily be adapted for high school or AP biology classes.Kristi HallJackson DunitzPatricia ShieldsAmerican Society for MicrobiologyarticleSpecial aspects of educationLC8-6691Biology (General)QH301-705.5ENJournal of Microbiology & Biology Education, Vol 15, Iss 2, Pp 307-309 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Special aspects of education LC8-6691 Biology (General) QH301-705.5
spellingShingle	Special aspects of education LC8-6691 Biology (General) QH301-705.5 Kristi Hall Jackson Dunitz Patricia Shields Build-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>
description	Many introductory biology students have a weak (or nonexistent) chemistry background. Due to this apparent knowledge gap, many students struggle to understand the process of polypeptide formation via dehydration synthesis as well as the interactions between individual polypeptide chains. This inability to reason about how individual amino acids interact with one another prevents students from making the cognitive leap from primary to secondary structure. In turn, students do not fully understand how even higher levels of organizations (i.e., tertiary and quaternary interactions) form the final three-dimensional configurations of proteins. We designed Build-a-Polypeptide in an attempt to help fill the part of the knowledge gap. In this activity, students physically represent the process of polypeptide synthesis and R group interactions using a paper model. Essentially, this is a simple cut and paste project that allows students to build a beginner's (i.e., highly truncated and simplified) model of protein folding. Previous research has shown that physical modeling can aid student understanding of complex topics (1,2). With that in mind, we developed this interactive activity to improve student understanding of protein synthesis and structure formation. This activity requires no laboratory equipment and can be completed within one (50 minute) class. Our worksheets were designed for use in introductory college-level biology courses, but could easily be adapted for high school or AP biology classes.
format	article
author	Kristi Hall Jackson Dunitz Patricia Shields
author_facet	Kristi Hall Jackson Dunitz Patricia Shields
author_sort	Kristi Hall
title	Build-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>
title_short	Build-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>
title_full	Build-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>
title_fullStr	Build-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>
title_full_unstemmed	Build-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>
title_sort	build-a-polypeptide: a hands-on worksheet to enhance student learning in an introductory biology course <sup> </sup>
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/f2089e74cc884b8881c6fde896649296
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Build-a-Polypeptide: A Hands-On Worksheet to Enhance Student Learning in an Introductory Biology Course <sup> </sup>

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