Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer

Epithelial ovarian cancer (EOC) has low mutational load. Here the authors analyze circulating and tumor-infiltrating lymphocytes (TILs) from 19 EOC patients and report frequent recovery of neo-antigen-reactive T cells from both compartments but with distinct TCR repertoires that have higher affinity...

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Autores principales:	Sara Bobisse, Raphael Genolet, Annalisa Roberti, Janos L. Tanyi, Julien Racle, Brian J. Stevenson, Christian Iseli, Alexandra Michel, Marie-Aude Le Bitoux, Philippe Guillaume, Julien Schmidt, Valentina Bianchi, Denarda Dangaj, Craig Fenwick, Laurent Derré, Ioannis Xenarios, Olivier Michielin, Pedro Romero, Dimitri S. Monos, Vincent Zoete, David Gfeller, Lana E. Kandalaft, George Coukos, Alexandre Harari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f208f1e6db6944a78773c68825834778
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spelling	oai:doaj.org-article:f208f1e6db6944a78773c688258347782021-12-02T14:38:52ZSensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer10.1038/s41467-018-03301-02041-1723https://doaj.org/article/f208f1e6db6944a78773c688258347782018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03301-0https://doaj.org/toc/2041-1723Epithelial ovarian cancer (EOC) has low mutational load. Here the authors analyze circulating and tumor-infiltrating lymphocytes (TILs) from 19 EOC patients and report frequent recovery of neo-antigen-reactive T cells from both compartments but with distinct TCR repertoires that have higher affinity in TILs.Sara BobisseRaphael GenoletAnnalisa RobertiJanos L. TanyiJulien RacleBrian J. StevensonChristian IseliAlexandra MichelMarie-Aude Le BitouxPhilippe GuillaumeJulien SchmidtValentina BianchiDenarda DangajCraig FenwickLaurent DerréIoannis XenariosOlivier MichielinPedro RomeroDimitri S. MonosVincent ZoeteDavid GfellerLana E. KandalaftGeorge CoukosAlexandre HarariNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Bobisse Raphael Genolet Annalisa Roberti Janos L. Tanyi Julien Racle Brian J. Stevenson Christian Iseli Alexandra Michel Marie-Aude Le Bitoux Philippe Guillaume Julien Schmidt Valentina Bianchi Denarda Dangaj Craig Fenwick Laurent Derré Ioannis Xenarios Olivier Michielin Pedro Romero Dimitri S. Monos Vincent Zoete David Gfeller Lana E. Kandalaft George Coukos Alexandre Harari Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer
description	Epithelial ovarian cancer (EOC) has low mutational load. Here the authors analyze circulating and tumor-infiltrating lymphocytes (TILs) from 19 EOC patients and report frequent recovery of neo-antigen-reactive T cells from both compartments but with distinct TCR repertoires that have higher affinity in TILs.
format	article
author	Sara Bobisse Raphael Genolet Annalisa Roberti Janos L. Tanyi Julien Racle Brian J. Stevenson Christian Iseli Alexandra Michel Marie-Aude Le Bitoux Philippe Guillaume Julien Schmidt Valentina Bianchi Denarda Dangaj Craig Fenwick Laurent Derré Ioannis Xenarios Olivier Michielin Pedro Romero Dimitri S. Monos Vincent Zoete David Gfeller Lana E. Kandalaft George Coukos Alexandre Harari
author_facet	Sara Bobisse Raphael Genolet Annalisa Roberti Janos L. Tanyi Julien Racle Brian J. Stevenson Christian Iseli Alexandra Michel Marie-Aude Le Bitoux Philippe Guillaume Julien Schmidt Valentina Bianchi Denarda Dangaj Craig Fenwick Laurent Derré Ioannis Xenarios Olivier Michielin Pedro Romero Dimitri S. Monos Vincent Zoete David Gfeller Lana E. Kandalaft George Coukos Alexandre Harari
author_sort	Sara Bobisse
title	Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer
title_short	Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer
title_full	Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer
title_fullStr	Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer
title_full_unstemmed	Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer
title_sort	sensitive and frequent identification of high avidity neo-epitope specific cd8 + t cells in immunotherapy-naive ovarian cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f208f1e6db6944a78773c68825834778
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Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer

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