THE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS

The theory of polyetiological tumorigenesis is one of the most important theories of carcinogenesis. A great place in this theory is given to the role of inflammatory component, which is implemented via the factors of innate immunity. I.e., toll-like receptors (TLRs), chemokines and their receptors...

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Autores principales:	O. A. Svitich, A. B. Filina, N. V. Davydova, L. V. Gankovskaya, V. V. Zverev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	innate immunity toll-like receptors (tlr) chemokines tumorigenesis genetics Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f20a670de89a4583a4a878e38a53ccd0
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spelling	oai:doaj.org-article:f20a670de89a4583a4a878e38a53ccd02021-11-18T08:03:47ZTHE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS1563-06252313-741X10.15789/1563-0625-2018-2-151-162https://doaj.org/article/f20a670de89a4583a4a878e38a53ccd02018-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1477https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe theory of polyetiological tumorigenesis is one of the most important theories of carcinogenesis. A great place in this theory is given to the role of inflammatory component, which is implemented via the factors of innate immunity. I.e., toll-like receptors (TLRs), chemokines and their receptors are related to innate immunity. Activation of TLRs may lead to regress or progression of cancer process. It is known that TLR3, TLR5, TLR7, TLR9 have the greatest anti-tumor effect due to the dendritic cells (DCs)-mediated activation of type I T helpers, activation of M1-type macrophages and Treg inhibition. Stimulation of TLR2 and TLR4 exerts an activating effect upon the tumor, by the MyD88 hyperactivation and secretion of IL-6 and TNFα, but exact mechanisms are not fully understood. In addition to TLRs, chemokines and their receptors have a great influence on the cancer development. It is shown that CCL2, CCL4, CCL17, CCL22 and CXCL12, which are secreted by cancer microenviroment, activate chemotaxis of tumor cells. It is also known that the chemokines activate CXCR4 and CCR7 (expressed by tumor cells) thus leading to metastasis.It is shown that there is an association between some gene polymorphisms of TLRs’, chemokines and their receptors, and development of cancer.Thus, we may conclude that the role of TLRs and chemokines is important in oncogenesis. Further study of innate immunity factors influencing tumorigenesis are important for finding new approaches to cancer therapy and new potential vaccines against cancer.O. A. SvitichA. B. FilinaN. V. DavydovaL. V. GankovskayaV. V. ZverevSPb RAACIarticleinnate immunitytoll-like receptors (tlr)chemokinestumorigenesisgeneticsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 2, Pp 151-162 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	innate immunity toll-like receptors (tlr) chemokines tumorigenesis genetics Immunologic diseases. Allergy RC581-607
spellingShingle	innate immunity toll-like receptors (tlr) chemokines tumorigenesis genetics Immunologic diseases. Allergy RC581-607 O. A. Svitich A. B. Filina N. V. Davydova L. V. Gankovskaya V. V. Zverev THE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS
description	The theory of polyetiological tumorigenesis is one of the most important theories of carcinogenesis. A great place in this theory is given to the role of inflammatory component, which is implemented via the factors of innate immunity. I.e., toll-like receptors (TLRs), chemokines and their receptors are related to innate immunity. Activation of TLRs may lead to regress or progression of cancer process. It is known that TLR3, TLR5, TLR7, TLR9 have the greatest anti-tumor effect due to the dendritic cells (DCs)-mediated activation of type I T helpers, activation of M1-type macrophages and Treg inhibition. Stimulation of TLR2 and TLR4 exerts an activating effect upon the tumor, by the MyD88 hyperactivation and secretion of IL-6 and TNFα, but exact mechanisms are not fully understood. In addition to TLRs, chemokines and their receptors have a great influence on the cancer development. It is shown that CCL2, CCL4, CCL17, CCL22 and CXCL12, which are secreted by cancer microenviroment, activate chemotaxis of tumor cells. It is also known that the chemokines activate CXCR4 and CCR7 (expressed by tumor cells) thus leading to metastasis.It is shown that there is an association between some gene polymorphisms of TLRs’, chemokines and their receptors, and development of cancer.Thus, we may conclude that the role of TLRs and chemokines is important in oncogenesis. Further study of innate immunity factors influencing tumorigenesis are important for finding new approaches to cancer therapy and new potential vaccines against cancer.
format	article
author	O. A. Svitich A. B. Filina N. V. Davydova L. V. Gankovskaya V. V. Zverev
author_facet	O. A. Svitich A. B. Filina N. V. Davydova L. V. Gankovskaya V. V. Zverev
author_sort	O. A. Svitich
title	THE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS
title_short	THE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS
title_full	THE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS
title_fullStr	THE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS
title_full_unstemmed	THE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS
title_sort	role of innate immunity factors in tumorigenesis process
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/f20a670de89a4583a4a878e38a53ccd0
work_keys_str_mv	AT oasvitich theroleofinnateimmunityfactorsintumorigenesisprocess AT abfilina theroleofinnateimmunityfactorsintumorigenesisprocess AT nvdavydova theroleofinnateimmunityfactorsintumorigenesisprocess AT lvgankovskaya theroleofinnateimmunityfactorsintumorigenesisprocess AT vvzverev theroleofinnateimmunityfactorsintumorigenesisprocess AT oasvitich roleofinnateimmunityfactorsintumorigenesisprocess AT abfilina roleofinnateimmunityfactorsintumorigenesisprocess AT nvdavydova roleofinnateimmunityfactorsintumorigenesisprocess AT lvgankovskaya roleofinnateimmunityfactorsintumorigenesisprocess AT vvzverev roleofinnateimmunityfactorsintumorigenesisprocess
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THE ROLE OF INNATE IMMUNITY FACTORS IN TUMORIGENESIS PROCESS

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