Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen

Ibuprofen is a potent non-steroidal anti-inflammatory drug due to its analgesic, antipyretic, and anti-inflammatory actions. However, its poor solubility in water makes it difficult to manufacture ibuprofen tablets, which limited the application of ibuprofen in drug delivery systems. Polymer–drug ae...

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Autores principales:	Chen Li, Ke Wang, Dong Xie
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	transdermal drug delivery system chitosan–ibuprofen aerogels ex vivo skin permeation drug release mechanism pH-responsive Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f210ac2c50cf475ea099a99999b08af4
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spelling	oai:doaj.org-article:f210ac2c50cf475ea099a99999b08af42021-11-08T14:29:32ZGreen Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen2296-264610.3389/fchem.2021.767923https://doaj.org/article/f210ac2c50cf475ea099a99999b08af42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.767923/fullhttps://doaj.org/toc/2296-2646Ibuprofen is a potent non-steroidal anti-inflammatory drug due to its analgesic, antipyretic, and anti-inflammatory actions. However, its poor solubility in water makes it difficult to manufacture ibuprofen tablets, which limited the application of ibuprofen in drug delivery systems. Polymer–drug aerogels have attracted huge interest in optimizing the drug delivery efficiency and improving the physicochemical characteristics and therapeutic quality. Here, chitosan–ibuprofen aerogels with excellent swelling, high biocompatibility, and better drug delivery efficiency were synthesized by a simple method. Our study found that the chitosan–ibuprofen aerogels exhibited remarkably improved thermal stability, excellent swelling ratio, and high drug loading. As a consequence of these favorable properties, the chitosan–ibuprofen aerogels exhibited improved drug delivery efficiency and achieved drug prolonged administration. Our study highlights the great potential of polymer–drug aerogels in improving the drug delivery efficiency of transdermal drug delivery systems.Chen LiChen LiKe WangKe WangDong XieDong XieFrontiers Media S.A.articletransdermal drug delivery systemchitosan–ibuprofen aerogelsex vivo skin permeationdrug release mechanismpH-responsiveChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transdermal drug delivery system chitosan–ibuprofen aerogels ex vivo skin permeation drug release mechanism pH-responsive Chemistry QD1-999
spellingShingle	transdermal drug delivery system chitosan–ibuprofen aerogels ex vivo skin permeation drug release mechanism pH-responsive Chemistry QD1-999 Chen Li Chen Li Ke Wang Ke Wang Dong Xie Dong Xie Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen
description	Ibuprofen is a potent non-steroidal anti-inflammatory drug due to its analgesic, antipyretic, and anti-inflammatory actions. However, its poor solubility in water makes it difficult to manufacture ibuprofen tablets, which limited the application of ibuprofen in drug delivery systems. Polymer–drug aerogels have attracted huge interest in optimizing the drug delivery efficiency and improving the physicochemical characteristics and therapeutic quality. Here, chitosan–ibuprofen aerogels with excellent swelling, high biocompatibility, and better drug delivery efficiency were synthesized by a simple method. Our study found that the chitosan–ibuprofen aerogels exhibited remarkably improved thermal stability, excellent swelling ratio, and high drug loading. As a consequence of these favorable properties, the chitosan–ibuprofen aerogels exhibited improved drug delivery efficiency and achieved drug prolonged administration. Our study highlights the great potential of polymer–drug aerogels in improving the drug delivery efficiency of transdermal drug delivery systems.
format	article
author	Chen Li Chen Li Ke Wang Ke Wang Dong Xie Dong Xie
author_facet	Chen Li Chen Li Ke Wang Ke Wang Dong Xie Dong Xie
author_sort	Chen Li
title	Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen
title_short	Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen
title_full	Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen
title_fullStr	Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen
title_full_unstemmed	Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen
title_sort	green fabrication and release mechanisms of ph-sensitive chitosan–ibuprofen aerogels for controlled transdermal delivery of ibuprofen
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f210ac2c50cf475ea099a99999b08af4
work_keys_str_mv	AT chenli greenfabricationandreleasemechanismsofphsensitivechitosanibuprofenaerogelsforcontrolledtransdermaldeliveryofibuprofen AT chenli greenfabricationandreleasemechanismsofphsensitivechitosanibuprofenaerogelsforcontrolledtransdermaldeliveryofibuprofen AT kewang greenfabricationandreleasemechanismsofphsensitivechitosanibuprofenaerogelsforcontrolledtransdermaldeliveryofibuprofen AT kewang greenfabricationandreleasemechanismsofphsensitivechitosanibuprofenaerogelsforcontrolledtransdermaldeliveryofibuprofen AT dongxie greenfabricationandreleasemechanismsofphsensitivechitosanibuprofenaerogelsforcontrolledtransdermaldeliveryofibuprofen AT dongxie greenfabricationandreleasemechanismsofphsensitivechitosanibuprofenaerogelsforcontrolledtransdermaldeliveryofibuprofen
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Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen

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