Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword

Reactive oxygen species (ROS) are critical mediators in many physiological processes including innate and adaptive immunity, making the modulation of ROS level a powerful strategy to augment anticancer immunity. However, current evidences suggest the necessity of a deeper understanding of their mult...

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Autores principales:	Jie Wang, Ning Liu, Hongfei Jiang, Qian Li, Dongming Xing
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ROS immunotherapy macrophage polarization T cell activation immunogenic cell death Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/f210d43dd16945698f52750385c345af
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spelling	oai:doaj.org-article:f210d43dd16945698f52750385c345af2021-11-17T07:03:17ZReactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword2296-418510.3389/fbioe.2021.784612https://doaj.org/article/f210d43dd16945698f52750385c345af2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.784612/fullhttps://doaj.org/toc/2296-4185Reactive oxygen species (ROS) are critical mediators in many physiological processes including innate and adaptive immunity, making the modulation of ROS level a powerful strategy to augment anticancer immunity. However, current evidences suggest the necessity of a deeper understanding of their multiple roles, which may vary with their concentration, location and the immune microenvironment they are in. Here, we have reviewed the reported effects of ROS on macrophage polarization, immune checkpoint blocking (ICB) therapy, T cell activation and expansion, as well as the induction of immunogenic cell death. A majority of reports are indicating detrimental effects of ROS, but it is unadvisable to simply scavenge them because of their pleiotropic effects in most occasions (except in T cell activation and expansion where ROS are generally undesirable). Therefore, clinical success will need a clearer illustration of their multi-faced functions, as well as more advanced technologies to tune ROS level with high spatiotemporal control and species-specificity. With such progresses, the efficacy of current immunotherapies will be greatly improved by combining with ROS-targeted therapies.Jie WangJie WangNing LiuHongfei JiangHongfei JiangQian LiDongming XingDongming XingDongming XingFrontiers Media S.A.articleROSimmunotherapymacrophage polarizationT cell activationimmunogenic cell deathBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ROS immunotherapy macrophage polarization T cell activation immunogenic cell death Biotechnology TP248.13-248.65
spellingShingle	ROS immunotherapy macrophage polarization T cell activation immunogenic cell death Biotechnology TP248.13-248.65 Jie Wang Jie Wang Ning Liu Hongfei Jiang Hongfei Jiang Qian Li Dongming Xing Dongming Xing Dongming Xing Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword
description	Reactive oxygen species (ROS) are critical mediators in many physiological processes including innate and adaptive immunity, making the modulation of ROS level a powerful strategy to augment anticancer immunity. However, current evidences suggest the necessity of a deeper understanding of their multiple roles, which may vary with their concentration, location and the immune microenvironment they are in. Here, we have reviewed the reported effects of ROS on macrophage polarization, immune checkpoint blocking (ICB) therapy, T cell activation and expansion, as well as the induction of immunogenic cell death. A majority of reports are indicating detrimental effects of ROS, but it is unadvisable to simply scavenge them because of their pleiotropic effects in most occasions (except in T cell activation and expansion where ROS are generally undesirable). Therefore, clinical success will need a clearer illustration of their multi-faced functions, as well as more advanced technologies to tune ROS level with high spatiotemporal control and species-specificity. With such progresses, the efficacy of current immunotherapies will be greatly improved by combining with ROS-targeted therapies.
format	article
author	Jie Wang Jie Wang Ning Liu Hongfei Jiang Hongfei Jiang Qian Li Dongming Xing Dongming Xing Dongming Xing
author_facet	Jie Wang Jie Wang Ning Liu Hongfei Jiang Hongfei Jiang Qian Li Dongming Xing Dongming Xing Dongming Xing
author_sort	Jie Wang
title	Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword
title_short	Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword
title_full	Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword
title_fullStr	Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword
title_full_unstemmed	Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword
title_sort	reactive oxygen species in anticancer immunity: a double-edged sword
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f210d43dd16945698f52750385c345af
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Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword

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