Structural basis for the target specificity of actin histidine methyltransferase SETD3

SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.

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Autores principales:	Shaobo Dai, John R. Horton, Clayton B. Woodcock, Alex W. Wilkinson, Xing Zhang, Or Gozani, Xiaodong Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2129526184a4597af28ea92c757a4b4
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spelling	oai:doaj.org-article:f2129526184a4597af28ea92c757a4b42021-12-02T16:57:50ZStructural basis for the target specificity of actin histidine methyltransferase SETD310.1038/s41467-019-11554-62041-1723https://doaj.org/article/f2129526184a4597af28ea92c757a4b42019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11554-6https://doaj.org/toc/2041-1723SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.Shaobo DaiJohn R. HortonClayton B. WoodcockAlex W. WilkinsonXing ZhangOr GozaniXiaodong ChengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaobo Dai John R. Horton Clayton B. Woodcock Alex W. Wilkinson Xing Zhang Or Gozani Xiaodong Cheng Structural basis for the target specificity of actin histidine methyltransferase SETD3
description	SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.
format	article
author	Shaobo Dai John R. Horton Clayton B. Woodcock Alex W. Wilkinson Xing Zhang Or Gozani Xiaodong Cheng
author_facet	Shaobo Dai John R. Horton Clayton B. Woodcock Alex W. Wilkinson Xing Zhang Or Gozani Xiaodong Cheng
author_sort	Shaobo Dai
title	Structural basis for the target specificity of actin histidine methyltransferase SETD3
title_short	Structural basis for the target specificity of actin histidine methyltransferase SETD3
title_full	Structural basis for the target specificity of actin histidine methyltransferase SETD3
title_fullStr	Structural basis for the target specificity of actin histidine methyltransferase SETD3
title_full_unstemmed	Structural basis for the target specificity of actin histidine methyltransferase SETD3
title_sort	structural basis for the target specificity of actin histidine methyltransferase setd3
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f2129526184a4597af28ea92c757a4b4
work_keys_str_mv	AT shaobodai structuralbasisforthetargetspecificityofactinhistidinemethyltransferasesetd3 AT johnrhorton structuralbasisforthetargetspecificityofactinhistidinemethyltransferasesetd3 AT claytonbwoodcock structuralbasisforthetargetspecificityofactinhistidinemethyltransferasesetd3 AT alexwwilkinson structuralbasisforthetargetspecificityofactinhistidinemethyltransferasesetd3 AT xingzhang structuralbasisforthetargetspecificityofactinhistidinemethyltransferasesetd3 AT orgozani structuralbasisforthetargetspecificityofactinhistidinemethyltransferasesetd3 AT xiaodongcheng structuralbasisforthetargetspecificityofactinhistidinemethyltransferasesetd3
_version_	1718382482394447872

Structural basis for the target specificity of actin histidine methyltransferase SETD3

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