Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation

Ubiquitylation of histone H3 (H3Ub2) by UHRF1 recruits DNMT1 to chromatin, which is essential for DNA methylation inheritance. Here, the authors provide evidence that there are two distinct mechanisms underlying replication timing-dependent recruitment of DNMT1 through PAF15Ub2 and H3Ub2, both of wh...

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Autores principales:	Atsuya Nishiyama, Christopher B. Mulholland, Sebastian Bultmann, Satomi Kori, Akinori Endo, Yasushi Saeki, Weihua Qin, Carina Trummer, Yoshie Chiba, Haruka Yokoyama, Soichiro Kumamoto, Toru Kawakami, Hironobu Hojo, Genta Nagae, Hiroyuki Aburatani, Keiji Tanaka, Kyohei Arita, Heinrich Leonhardt, Makoto Nakanishi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f213b943c175422e80039e7fcf8e3765
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spelling	oai:doaj.org-article:f213b943c175422e80039e7fcf8e37652021-12-02T15:39:12ZTwo distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation10.1038/s41467-020-15006-42041-1723https://doaj.org/article/f213b943c175422e80039e7fcf8e37652020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15006-4https://doaj.org/toc/2041-1723Ubiquitylation of histone H3 (H3Ub2) by UHRF1 recruits DNMT1 to chromatin, which is essential for DNA methylation inheritance. Here, the authors provide evidence that there are two distinct mechanisms underlying replication timing-dependent recruitment of DNMT1 through PAF15Ub2 and H3Ub2, both of which are required for high fidelity DNA methylation inheritance.Atsuya NishiyamaChristopher B. MulhollandSebastian BultmannSatomi KoriAkinori EndoYasushi SaekiWeihua QinCarina TrummerYoshie ChibaHaruka YokoyamaSoichiro KumamotoToru KawakamiHironobu HojoGenta NagaeHiroyuki AburataniKeiji TanakaKyohei AritaHeinrich LeonhardtMakoto NakanishiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Atsuya Nishiyama Christopher B. Mulholland Sebastian Bultmann Satomi Kori Akinori Endo Yasushi Saeki Weihua Qin Carina Trummer Yoshie Chiba Haruka Yokoyama Soichiro Kumamoto Toru Kawakami Hironobu Hojo Genta Nagae Hiroyuki Aburatani Keiji Tanaka Kyohei Arita Heinrich Leonhardt Makoto Nakanishi Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
description	Ubiquitylation of histone H3 (H3Ub2) by UHRF1 recruits DNMT1 to chromatin, which is essential for DNA methylation inheritance. Here, the authors provide evidence that there are two distinct mechanisms underlying replication timing-dependent recruitment of DNMT1 through PAF15Ub2 and H3Ub2, both of which are required for high fidelity DNA methylation inheritance.
format	article
author	Atsuya Nishiyama Christopher B. Mulholland Sebastian Bultmann Satomi Kori Akinori Endo Yasushi Saeki Weihua Qin Carina Trummer Yoshie Chiba Haruka Yokoyama Soichiro Kumamoto Toru Kawakami Hironobu Hojo Genta Nagae Hiroyuki Aburatani Keiji Tanaka Kyohei Arita Heinrich Leonhardt Makoto Nakanishi
author_facet	Atsuya Nishiyama Christopher B. Mulholland Sebastian Bultmann Satomi Kori Akinori Endo Yasushi Saeki Weihua Qin Carina Trummer Yoshie Chiba Haruka Yokoyama Soichiro Kumamoto Toru Kawakami Hironobu Hojo Genta Nagae Hiroyuki Aburatani Keiji Tanaka Kyohei Arita Heinrich Leonhardt Makoto Nakanishi
author_sort	Atsuya Nishiyama
title	Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
title_short	Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
title_full	Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
title_fullStr	Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
title_full_unstemmed	Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
title_sort	two distinct modes of dnmt1 recruitment ensure stable maintenance dna methylation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f213b943c175422e80039e7fcf8e3765
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Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation

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