Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)

Abstract Consumption of tea is inversely associated with cardiovascular diseases. However, the active compound(s) responsible for the protective effects of tea are unknown. Although many favorable cardiovascular effects in vitro are mediated by epigallocatechin gallate (EGCG), its contribution to th...

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Autores principales:	Mario Lorenz, Franziska Rauhut, Christine Hofer, Stefanie Gwosc, Eda Müller, Damaris Praeger, Benno F. Zimmermann, Klaus-Dieter Wernecke, Gert Baumann, Karl Stangl, Verena Stangl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f216721b2419437c87354a6d41672530
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spelling	oai:doaj.org-article:f216721b2419437c87354a6d416725302021-12-02T16:06:17ZTea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)10.1038/s41598-017-02384-x2045-2322https://doaj.org/article/f216721b2419437c87354a6d416725302017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02384-xhttps://doaj.org/toc/2045-2322Abstract Consumption of tea is inversely associated with cardiovascular diseases. However, the active compound(s) responsible for the protective effects of tea are unknown. Although many favorable cardiovascular effects in vitro are mediated by epigallocatechin gallate (EGCG), its contribution to the beneficial effects of tea in vivo remains unresolved. In a randomised crossover study, a single dose of 200 mg EGCG was applied in three different formulas (as green tea beverage, green tea extract (GTE), and isolated EGCG) to 50 healthy men. Flow-mediated dilation (FMD) and endothelial-independent nitro-mediated dilation (NMD) was measured before and two hours after ingestion. Plasma levels of tea compounds were determined after each intervention and correlated with FMD. FMD significantly improved after consumption of green tea containing 200 mg EGCG (p < 0.01). However, GTE and EGCG had no significant effect on FMD. NMD did not significantly differ between interventions. EGCG plasma levels were highest after administration of EGCG and lowest after consumption of green tea. Plasma levels of caffeine increased after green tea consumption. The results show that EGCG is most likely not involved in improvement of flow-mediated dilation by green tea. Instead, other tea compounds, metabolites or combinations thereof may play a role.Mario LorenzFranziska RauhutChristine HoferStefanie GwoscEda MüllerDamaris PraegerBenno F. ZimmermannKlaus-Dieter WerneckeGert BaumannKarl StanglVerena StanglNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mario Lorenz Franziska Rauhut Christine Hofer Stefanie Gwosc Eda Müller Damaris Praeger Benno F. Zimmermann Klaus-Dieter Wernecke Gert Baumann Karl Stangl Verena Stangl Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
description	Abstract Consumption of tea is inversely associated with cardiovascular diseases. However, the active compound(s) responsible for the protective effects of tea are unknown. Although many favorable cardiovascular effects in vitro are mediated by epigallocatechin gallate (EGCG), its contribution to the beneficial effects of tea in vivo remains unresolved. In a randomised crossover study, a single dose of 200 mg EGCG was applied in three different formulas (as green tea beverage, green tea extract (GTE), and isolated EGCG) to 50 healthy men. Flow-mediated dilation (FMD) and endothelial-independent nitro-mediated dilation (NMD) was measured before and two hours after ingestion. Plasma levels of tea compounds were determined after each intervention and correlated with FMD. FMD significantly improved after consumption of green tea containing 200 mg EGCG (p < 0.01). However, GTE and EGCG had no significant effect on FMD. NMD did not significantly differ between interventions. EGCG plasma levels were highest after administration of EGCG and lowest after consumption of green tea. Plasma levels of caffeine increased after green tea consumption. The results show that EGCG is most likely not involved in improvement of flow-mediated dilation by green tea. Instead, other tea compounds, metabolites or combinations thereof may play a role.
format	article
author	Mario Lorenz Franziska Rauhut Christine Hofer Stefanie Gwosc Eda Müller Damaris Praeger Benno F. Zimmermann Klaus-Dieter Wernecke Gert Baumann Karl Stangl Verena Stangl
author_facet	Mario Lorenz Franziska Rauhut Christine Hofer Stefanie Gwosc Eda Müller Damaris Praeger Benno F. Zimmermann Klaus-Dieter Wernecke Gert Baumann Karl Stangl Verena Stangl
author_sort	Mario Lorenz
title	Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_short	Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_full	Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_fullStr	Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_full_unstemmed	Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_sort	tea-induced improvement of endothelial function in humans: no role for epigallocatechin gallate (egcg)
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f216721b2419437c87354a6d41672530
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Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)

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