Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis

Health-related quality of life (HRQoL) is an essential complementary parameter in the assessment of disease burden and treatment outcome in multiple sclerosis (MS) and can be affected by neuropsychiatric symptoms, which in turn are sensitive to psychological stress. However, until now, the impact of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lil Meyer-Arndt, Tanja Schmitz-Hübsch, Judith Bellmann-Strobl, Alexander U. Brandt, John-Dylan Haynes, Stefan M. Gold, Friedemann Paul, Martin Weygandt
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	multiple sclerosis quality of life neuropsychiatric symptoms psychological stress functional magnet resonance imaging (fMRI) Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f21684548cdf42569ca349daef749df1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f21684548cdf42569ca349daef749df1
record_format	dspace
spelling	oai:doaj.org-article:f21684548cdf42569ca349daef749df12021-11-30T14:37:44ZNeural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis1664-229510.3389/fneur.2021.753107https://doaj.org/article/f21684548cdf42569ca349daef749df12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.753107/fullhttps://doaj.org/toc/1664-2295Health-related quality of life (HRQoL) is an essential complementary parameter in the assessment of disease burden and treatment outcome in multiple sclerosis (MS) and can be affected by neuropsychiatric symptoms, which in turn are sensitive to psychological stress. However, until now, the impact of neurobiological stress and relaxation on HRQoL in MS has not been investigated. We thus evaluated whether the activity of neural networks triggered by mild psychological stress (elicited in an fMRI task comprising mental arithmetic with feedback) or by stress termination (i.e., relaxation) at baseline (T0) predicts HRQoL variations occurring between T0 and a follow-up visit (T1) in 28 patients using a robust regression and permutation testing. The median delay between T0 and T1 was 902 (range: 363–1,169) days. We assessed HRQoL based on the Hamburg Quality of Life Questionnaire in MS (HAQUAMS) and accounted for the impact of established HRQoL predictors and the cognitive performance of the participants. Relaxation-triggered activity of a widespread neural network predicted future variations in overall HRQoL (t = 3.68, pfamily−wise error [FWE]-corrected = 0.008). Complementary analyses showed that relaxation-triggered activity of the same network at baseline was associated with variations in the HAQUAMS mood subscale on an αFWE = 0.1 level (t = 3.37, pFWE = 0.087). Finally, stress-induced activity of a prefronto-limbic network predicted future variations in the HAQUAMS lower limb mobility subscale (t = −3.62, pFWE = 0.020). Functional neural network measures of psychological stress and relaxation contain prognostic information for future HRQoL evolution in MS independent of clinical predictors.Lil Meyer-ArndtLil Meyer-ArndtLil Meyer-ArndtTanja Schmitz-HübschTanja Schmitz-HübschJudith Bellmann-StroblJudith Bellmann-StroblAlexander U. BrandtAlexander U. BrandtJohn-Dylan HaynesJohn-Dylan HaynesJohn-Dylan HaynesStefan M. GoldStefan M. GoldStefan M. GoldFriedemann PaulFriedemann PaulFriedemann PaulMartin WeygandtMartin WeygandtFrontiers Media S.A.articlemultiple sclerosisquality of lifeneuropsychiatric symptomspsychological stressfunctional magnet resonance imaging (fMRI)Neurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis quality of life neuropsychiatric symptoms psychological stress functional magnet resonance imaging (fMRI) Neurology. Diseases of the nervous system RC346-429
spellingShingle	multiple sclerosis quality of life neuropsychiatric symptoms psychological stress functional magnet resonance imaging (fMRI) Neurology. Diseases of the nervous system RC346-429 Lil Meyer-Arndt Lil Meyer-Arndt Lil Meyer-Arndt Tanja Schmitz-Hübsch Tanja Schmitz-Hübsch Judith Bellmann-Strobl Judith Bellmann-Strobl Alexander U. Brandt Alexander U. Brandt John-Dylan Haynes John-Dylan Haynes John-Dylan Haynes Stefan M. Gold Stefan M. Gold Stefan M. Gold Friedemann Paul Friedemann Paul Friedemann Paul Martin Weygandt Martin Weygandt Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis
description	Health-related quality of life (HRQoL) is an essential complementary parameter in the assessment of disease burden and treatment outcome in multiple sclerosis (MS) and can be affected by neuropsychiatric symptoms, which in turn are sensitive to psychological stress. However, until now, the impact of neurobiological stress and relaxation on HRQoL in MS has not been investigated. We thus evaluated whether the activity of neural networks triggered by mild psychological stress (elicited in an fMRI task comprising mental arithmetic with feedback) or by stress termination (i.e., relaxation) at baseline (T0) predicts HRQoL variations occurring between T0 and a follow-up visit (T1) in 28 patients using a robust regression and permutation testing. The median delay between T0 and T1 was 902 (range: 363–1,169) days. We assessed HRQoL based on the Hamburg Quality of Life Questionnaire in MS (HAQUAMS) and accounted for the impact of established HRQoL predictors and the cognitive performance of the participants. Relaxation-triggered activity of a widespread neural network predicted future variations in overall HRQoL (t = 3.68, pfamily−wise error [FWE]-corrected = 0.008). Complementary analyses showed that relaxation-triggered activity of the same network at baseline was associated with variations in the HAQUAMS mood subscale on an αFWE = 0.1 level (t = 3.37, pFWE = 0.087). Finally, stress-induced activity of a prefronto-limbic network predicted future variations in the HAQUAMS lower limb mobility subscale (t = −3.62, pFWE = 0.020). Functional neural network measures of psychological stress and relaxation contain prognostic information for future HRQoL evolution in MS independent of clinical predictors.
format	article
author	Lil Meyer-Arndt Lil Meyer-Arndt Lil Meyer-Arndt Tanja Schmitz-Hübsch Tanja Schmitz-Hübsch Judith Bellmann-Strobl Judith Bellmann-Strobl Alexander U. Brandt Alexander U. Brandt John-Dylan Haynes John-Dylan Haynes John-Dylan Haynes Stefan M. Gold Stefan M. Gold Stefan M. Gold Friedemann Paul Friedemann Paul Friedemann Paul Martin Weygandt Martin Weygandt
author_facet	Lil Meyer-Arndt Lil Meyer-Arndt Lil Meyer-Arndt Tanja Schmitz-Hübsch Tanja Schmitz-Hübsch Judith Bellmann-Strobl Judith Bellmann-Strobl Alexander U. Brandt Alexander U. Brandt John-Dylan Haynes John-Dylan Haynes John-Dylan Haynes Stefan M. Gold Stefan M. Gold Stefan M. Gold Friedemann Paul Friedemann Paul Friedemann Paul Martin Weygandt Martin Weygandt
author_sort	Lil Meyer-Arndt
title	Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis
title_short	Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis
title_full	Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis
title_fullStr	Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis
title_full_unstemmed	Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis
title_sort	neural processes of psychological stress and relaxation predict the future evolution of quality of life in multiple sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f21684548cdf42569ca349daef749df1
work_keys_str_mv	AT lilmeyerarndt neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT lilmeyerarndt neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT lilmeyerarndt neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT tanjaschmitzhubsch neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT tanjaschmitzhubsch neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT judithbellmannstrobl neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT judithbellmannstrobl neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT alexanderubrandt neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT alexanderubrandt neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT johndylanhaynes neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT johndylanhaynes neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT johndylanhaynes neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT stefanmgold neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT stefanmgold neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT stefanmgold neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT friedemannpaul neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT friedemannpaul neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT friedemannpaul neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT martinweygandt neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis AT martinweygandt neuralprocessesofpsychologicalstressandrelaxationpredictthefutureevolutionofqualityoflifeinmultiplesclerosis
_version_	1718406538898440192

Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis

Ejemplares similares