Bursting dynamics in the normal and failing hearts

Abstract A failing heart differs from healthy hearts by an array of symptomatic characteristics, including impaired Ca2+ transients, upregulation of Na+/Ca2+ exchanger function, reduction of Ca2+ uptake to sarcoplasmic reticulum, reduced K+ currents, and increased propensity to arrhythmias. While si...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vladimir E. Bondarenko, Andrey L. Shilnikov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2173b0bd7394afe8e0a6efc5bf985f7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f2173b0bd7394afe8e0a6efc5bf985f7
record_format	dspace
spelling	oai:doaj.org-article:f2173b0bd7394afe8e0a6efc5bf985f72021-12-02T12:32:59ZBursting dynamics in the normal and failing hearts10.1038/s41598-017-05198-z2045-2322https://doaj.org/article/f2173b0bd7394afe8e0a6efc5bf985f72017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05198-zhttps://doaj.org/toc/2045-2322Abstract A failing heart differs from healthy hearts by an array of symptomatic characteristics, including impaired Ca2+ transients, upregulation of Na+/Ca2+ exchanger function, reduction of Ca2+ uptake to sarcoplasmic reticulum, reduced K+ currents, and increased propensity to arrhythmias. While significant efforts have been made in both experimental studies and model development to display the causes of heart failure, the full process of deterioration from a healthy to a failing heart yet remains deficiently understood. In this paper, we analyze a highly detailed mathematical model of mouse ventricular myocytes to disclose the key mechanisms underlying the continual transition towards a state of heart failure. We argue that such a transition can be described in mathematical terms as a sequence of bifurcations that the healthy cells undergo while transforming into failing cells. They include normal action potentials and [Ca2+]i transients, action potential and [Ca2+]i alternans, and bursting behaviors. These behaviors where supported by experimental studies of heart failure. The analysis of this model allowed us to identify that the slow component of the fast Na+ current is a key determining factor for the onset of bursting activity in mouse ventricular myocytes.Vladimir E. BondarenkoAndrey L. ShilnikovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vladimir E. Bondarenko Andrey L. Shilnikov Bursting dynamics in the normal and failing hearts
description	Abstract A failing heart differs from healthy hearts by an array of symptomatic characteristics, including impaired Ca2+ transients, upregulation of Na+/Ca2+ exchanger function, reduction of Ca2+ uptake to sarcoplasmic reticulum, reduced K+ currents, and increased propensity to arrhythmias. While significant efforts have been made in both experimental studies and model development to display the causes of heart failure, the full process of deterioration from a healthy to a failing heart yet remains deficiently understood. In this paper, we analyze a highly detailed mathematical model of mouse ventricular myocytes to disclose the key mechanisms underlying the continual transition towards a state of heart failure. We argue that such a transition can be described in mathematical terms as a sequence of bifurcations that the healthy cells undergo while transforming into failing cells. They include normal action potentials and [Ca2+]i transients, action potential and [Ca2+]i alternans, and bursting behaviors. These behaviors where supported by experimental studies of heart failure. The analysis of this model allowed us to identify that the slow component of the fast Na+ current is a key determining factor for the onset of bursting activity in mouse ventricular myocytes.
format	article
author	Vladimir E. Bondarenko Andrey L. Shilnikov
author_facet	Vladimir E. Bondarenko Andrey L. Shilnikov
author_sort	Vladimir E. Bondarenko
title	Bursting dynamics in the normal and failing hearts
title_short	Bursting dynamics in the normal and failing hearts
title_full	Bursting dynamics in the normal and failing hearts
title_fullStr	Bursting dynamics in the normal and failing hearts
title_full_unstemmed	Bursting dynamics in the normal and failing hearts
title_sort	bursting dynamics in the normal and failing hearts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f2173b0bd7394afe8e0a6efc5bf985f7
work_keys_str_mv	AT vladimirebondarenko burstingdynamicsinthenormalandfailinghearts AT andreylshilnikov burstingdynamicsinthenormalandfailinghearts
_version_	1718393954684108800

Bursting dynamics in the normal and failing hearts

Ejemplares similares