A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide

The SARS-CoV-2 nsp16/nsp10 enzyme complex methylates the 2′-OH of the first nucleotide of the viral mRNA, converting the Cap-0 to Cap-1, which helps the virus to evade immune surveillance in the host cell. Here, the authors present the crystal structure of SARS-CoV-2 nsp16/nsp10 with the bound Cap-1...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thiruselvam Viswanathan, Anurag Misra, Siu-Hong Chan, Shan Qi, Nan Dai, Shailee Arya, Luis Martinez-Sobrido, Yogesh K. Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f218a0ba562445fea22bd96245c64491
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f218a0ba562445fea22bd96245c64491
record_format	dspace
spelling	oai:doaj.org-article:f218a0ba562445fea22bd96245c644912021-12-02T18:24:49ZA metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide10.1038/s41467-021-23594-y2041-1723https://doaj.org/article/f218a0ba562445fea22bd96245c644912021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23594-yhttps://doaj.org/toc/2041-1723The SARS-CoV-2 nsp16/nsp10 enzyme complex methylates the 2′-OH of the first nucleotide of the viral mRNA, converting the Cap-0 to Cap-1, which helps the virus to evade immune surveillance in the host cell. Here, the authors present the crystal structure of SARS-CoV-2 nsp16/nsp10 with the bound Cap-1 RNA nucleotide product and a post-release SAH containing structure.Thiruselvam ViswanathanAnurag MisraSiu-Hong ChanShan QiNan DaiShailee AryaLuis Martinez-SobridoYogesh K. GuptaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thiruselvam Viswanathan Anurag Misra Siu-Hong Chan Shan Qi Nan Dai Shailee Arya Luis Martinez-Sobrido Yogesh K. Gupta A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
description	The SARS-CoV-2 nsp16/nsp10 enzyme complex methylates the 2′-OH of the first nucleotide of the viral mRNA, converting the Cap-0 to Cap-1, which helps the virus to evade immune surveillance in the host cell. Here, the authors present the crystal structure of SARS-CoV-2 nsp16/nsp10 with the bound Cap-1 RNA nucleotide product and a post-release SAH containing structure.
format	article
author	Thiruselvam Viswanathan Anurag Misra Siu-Hong Chan Shan Qi Nan Dai Shailee Arya Luis Martinez-Sobrido Yogesh K. Gupta
author_facet	Thiruselvam Viswanathan Anurag Misra Siu-Hong Chan Shan Qi Nan Dai Shailee Arya Luis Martinez-Sobrido Yogesh K. Gupta
author_sort	Thiruselvam Viswanathan
title	A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
title_short	A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
title_full	A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
title_fullStr	A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
title_full_unstemmed	A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
title_sort	metal ion orients sars-cov-2 mrna to ensure accurate 2′-o methylation of its first nucleotide
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f218a0ba562445fea22bd96245c64491
work_keys_str_mv	AT thiruselvamviswanathan ametalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT anuragmisra ametalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT siuhongchan ametalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT shanqi ametalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT nandai ametalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT shaileearya ametalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT luismartinezsobrido ametalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT yogeshkgupta ametalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT thiruselvamviswanathan metalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT anuragmisra metalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT siuhongchan metalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT shanqi metalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT nandai metalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT shaileearya metalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT luismartinezsobrido metalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide AT yogeshkgupta metalionorientssarscov2mrnatoensureaccurate2omethylationofitsfirstnucleotide
_version_	1718378134422683648

A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide

Ejemplares similares