Adjunctive enteral phenobarbital for adult status epilepticus: a brief report

Somsak Tiamkao,1,2 Kornkanok Suttapan,1 Sineenard Pranbul,2,3 Siriporn Tiamkao,2,4 Kittisak Sawanyawisuth,1,5 Integrated Epilepsy Research group21Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Integrated Epilepsy Research Group, Khon Kaen University, Khon Ka...

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Autores principales:	Tiamkao S, Suttapan K, Pranbul S, Sawanyawisuth K, Integrated Epilepsy Research group
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f2196779874e4511aa5c442faf2c421e
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spelling	oai:doaj.org-article:f2196779874e4511aa5c442faf2c421e2021-12-02T06:48:02ZAdjunctive enteral phenobarbital for adult status epilepticus: a brief report1176-63281178-2021https://doaj.org/article/f2196779874e4511aa5c442faf2c421e2013-11-01T00:00:00Zhttp://www.dovepress.com/adjunctive-enteral-phenobarbital-for-adult-status-epilepticus-a-brief--a15091https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Somsak Tiamkao,1,2 Kornkanok Suttapan,1 Sineenard Pranbul,2,3 Siriporn Tiamkao,2,4 Kittisak Sawanyawisuth,1,5 Integrated Epilepsy Research group21Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Integrated Epilepsy Research Group, Khon Kaen University, Khon Kaen, Thailand; 3Nursing Division, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 4Department of Pharmacy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 5The Research and Training Center for Enhancing Quality of Life of Working-Age People, Khon Kaen University, Khon Kaen, ThailandBackground: Status epilepticus (SE) is a neurological emergency condition. Intravenous phenobarbital (PB) is recommended for refractory SE treatment. However, intravenous PB is unavailable in Thailand. Enteral PB has been shown to be effective in SE children.Methods: In adult SE patients, the efficacy of enteral PB as an adjunctive therapy has been reported. This is a case series of adult SE patients who were treated with enteral PB at Khon Kaen University Hospital, Thailand. The clinical features and clinical outcomes are reported.Results: There were six patients; five patients had convulsive SE, and one patient had nonconvulsive SE. All patients received PB enterally, at dosages of 900 mg initially and repeated doses of 900 mg as needed. This was gradually reduced to a maintenance dosage of 180 mg/day. Three out of six patients were completely controlled, whereas the other three patients were partially controlled. Three out of six patients were seizure-free after the initial loading dose of PB. No adverse effects were found in this study.Conclusion: In adult patients, enteral PB may be effective as an add-on for refractory SE therapy.Keywords: clinical outcomes, refractory status epilepticus, Thailand, efficacyTiamkao SSuttapan KPranbul STiamkao SSawanyawisuth KIntegrated Epilepsy Research groupDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1829-1834 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tiamkao S Suttapan K Pranbul S Tiamkao S Sawanyawisuth K Integrated Epilepsy Research group Adjunctive enteral phenobarbital for adult status epilepticus: a brief report
description	Somsak Tiamkao,1,2 Kornkanok Suttapan,1 Sineenard Pranbul,2,3 Siriporn Tiamkao,2,4 Kittisak Sawanyawisuth,1,5 Integrated Epilepsy Research group21Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Integrated Epilepsy Research Group, Khon Kaen University, Khon Kaen, Thailand; 3Nursing Division, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 4Department of Pharmacy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 5The Research and Training Center for Enhancing Quality of Life of Working-Age People, Khon Kaen University, Khon Kaen, ThailandBackground: Status epilepticus (SE) is a neurological emergency condition. Intravenous phenobarbital (PB) is recommended for refractory SE treatment. However, intravenous PB is unavailable in Thailand. Enteral PB has been shown to be effective in SE children.Methods: In adult SE patients, the efficacy of enteral PB as an adjunctive therapy has been reported. This is a case series of adult SE patients who were treated with enteral PB at Khon Kaen University Hospital, Thailand. The clinical features and clinical outcomes are reported.Results: There were six patients; five patients had convulsive SE, and one patient had nonconvulsive SE. All patients received PB enterally, at dosages of 900 mg initially and repeated doses of 900 mg as needed. This was gradually reduced to a maintenance dosage of 180 mg/day. Three out of six patients were completely controlled, whereas the other three patients were partially controlled. Three out of six patients were seizure-free after the initial loading dose of PB. No adverse effects were found in this study.Conclusion: In adult patients, enteral PB may be effective as an add-on for refractory SE therapy.Keywords: clinical outcomes, refractory status epilepticus, Thailand, efficacy
format	article
author	Tiamkao S Suttapan K Pranbul S Tiamkao S Sawanyawisuth K Integrated Epilepsy Research group
author_facet	Tiamkao S Suttapan K Pranbul S Tiamkao S Sawanyawisuth K Integrated Epilepsy Research group
author_sort	Tiamkao S
title	Adjunctive enteral phenobarbital for adult status epilepticus: a brief report
title_short	Adjunctive enteral phenobarbital for adult status epilepticus: a brief report
title_full	Adjunctive enteral phenobarbital for adult status epilepticus: a brief report
title_fullStr	Adjunctive enteral phenobarbital for adult status epilepticus: a brief report
title_full_unstemmed	Adjunctive enteral phenobarbital for adult status epilepticus: a brief report
title_sort	adjunctive enteral phenobarbital for adult status epilepticus: a brief report
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f2196779874e4511aa5c442faf2c421e
work_keys_str_mv	AT tiamkaos adjunctiveenteralphenobarbitalforadultstatusepilepticusabriefreport AT suttapank adjunctiveenteralphenobarbitalforadultstatusepilepticusabriefreport AT pranbuls adjunctiveenteralphenobarbitalforadultstatusepilepticusabriefreport AT tiamkaos adjunctiveenteralphenobarbitalforadultstatusepilepticusabriefreport AT sawanyawisuthk adjunctiveenteralphenobarbitalforadultstatusepilepticusabriefreport AT integratedepilepsyresearchgroup adjunctiveenteralphenobarbitalforadultstatusepilepticusabriefreport
_version_	1718399788917981184

Adjunctive enteral phenobarbital for adult status epilepticus: a brief report

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