Primary decidual zone formation requires Scribble for pregnancy success in mice

The scaffold protein Scribble (Scrib) has roles in PCP and tight junction formation. Here the authors show that during embryo implantation in mouse, Scrib is needed to form the avascular primary decidual zone by transforming stromal cells into an epithelial cell-like barrier around the crypt, protec...

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Autores principales:	Jia Yuan, Shizu Aikawa, Wenbo Deng, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B. Huber, Xiaofei Sun, Sudhansu K. Dey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f219965601f64831b23b1f79def5b60b
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spelling	oai:doaj.org-article:f219965601f64831b23b1f79def5b60b2021-12-02T16:57:54ZPrimary decidual zone formation requires Scribble for pregnancy success in mice10.1038/s41467-019-13489-42041-1723https://doaj.org/article/f219965601f64831b23b1f79def5b60b2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13489-4https://doaj.org/toc/2041-1723The scaffold protein Scribble (Scrib) has roles in PCP and tight junction formation. Here the authors show that during embryo implantation in mouse, Scrib is needed to form the avascular primary decidual zone by transforming stromal cells into an epithelial cell-like barrier around the crypt, protecting the embryo from harmful infiltrations.Jia YuanShizu AikawaWenbo DengAmanda BartosGerd WalzFlorian GrahammerTobias B. HuberXiaofei SunSudhansu K. DeyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jia Yuan Shizu Aikawa Wenbo Deng Amanda Bartos Gerd Walz Florian Grahammer Tobias B. Huber Xiaofei Sun Sudhansu K. Dey Primary decidual zone formation requires Scribble for pregnancy success in mice
description	The scaffold protein Scribble (Scrib) has roles in PCP and tight junction formation. Here the authors show that during embryo implantation in mouse, Scrib is needed to form the avascular primary decidual zone by transforming stromal cells into an epithelial cell-like barrier around the crypt, protecting the embryo from harmful infiltrations.
format	article
author	Jia Yuan Shizu Aikawa Wenbo Deng Amanda Bartos Gerd Walz Florian Grahammer Tobias B. Huber Xiaofei Sun Sudhansu K. Dey
author_facet	Jia Yuan Shizu Aikawa Wenbo Deng Amanda Bartos Gerd Walz Florian Grahammer Tobias B. Huber Xiaofei Sun Sudhansu K. Dey
author_sort	Jia Yuan
title	Primary decidual zone formation requires Scribble for pregnancy success in mice
title_short	Primary decidual zone formation requires Scribble for pregnancy success in mice
title_full	Primary decidual zone formation requires Scribble for pregnancy success in mice
title_fullStr	Primary decidual zone formation requires Scribble for pregnancy success in mice
title_full_unstemmed	Primary decidual zone formation requires Scribble for pregnancy success in mice
title_sort	primary decidual zone formation requires scribble for pregnancy success in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f219965601f64831b23b1f79def5b60b
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Primary decidual zone formation requires Scribble for pregnancy success in mice

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