Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis
Takeo Isozaki, Michihito Sato, Ryo Takahashi, Kuninobu Wakabayashi, Nobuyuki Yajima, Yusuke Miwa, Masao Negishi, Hirotsugu Ide, Tsuyoshi KasamaDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, JapanAbstract: The aim of the present clinical trial was to det...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2010
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f21b461196624976a00bc73340ebfbde |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f21b461196624976a00bc73340ebfbde |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f21b461196624976a00bc73340ebfbde2021-12-02T08:27:26ZEffects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis1179-156Xhttps://doaj.org/article/f21b461196624976a00bc73340ebfbde2010-07-01T00:00:00Zhttp://www.dovepress.com/effects-of-low-dose-tacrolimus-therapy-in-combination-with-methotrexat-a4766https://doaj.org/toc/1179-156XTakeo Isozaki, Michihito Sato, Ryo Takahashi, Kuninobu Wakabayashi, Nobuyuki Yajima, Yusuke Miwa, Masao Negishi, Hirotsugu Ide, Tsuyoshi KasamaDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, JapanAbstract: The aim of the present clinical trial was to determine the efficacy and safety of low-dose administration of tacrolimus in combination with methotrexate (MTX) in rheumatoid arthritis (RA) patients with an insufficient clinical response to MTX alone. Eleven patients with active RA, despite treatment with MTX, were enrolled and given tacrolimus in combination with MTX for 24 weeks. The primary endpoint was the assessment of clinical improvement using the European League against Rheumatism criteria. Administration of ­tacrolimus to RA patients with an insufficient response to MTX produced significant improvement in the Disease Activity Score 28 after 8–24 weeks. In addition, after 24 weeks, 50% and 25% of patients had achieved moderate and good responses, respectively, and there were ­significant reductions in the Modified Health Assessment Questionnaire, the rheumatoid ­factor and serum matrix metalloproteinase-3 levels. The present preliminary study suggests that low-dose tacrolimus in combination with MTX is well tolerated and provides both clinical and economic benefits.Keywords: rheumatoid arthritis, methotrexate, tacrolimus, DAS28, mHAQ Takeo IsozakiMichihito SatoRyo Takahashiet alDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2010, Iss default, Pp 29-34 (2010) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Diseases of the musculoskeletal system RC925-935 |
| spellingShingle |
Diseases of the musculoskeletal system RC925-935 Takeo Isozaki Michihito Sato Ryo Takahashi et al Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis |
| description |
Takeo Isozaki, Michihito Sato, Ryo Takahashi, Kuninobu Wakabayashi, Nobuyuki Yajima, Yusuke Miwa, Masao Negishi, Hirotsugu Ide, Tsuyoshi KasamaDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, JapanAbstract: The aim of the present clinical trial was to determine the efficacy and safety of low-dose administration of tacrolimus in combination with methotrexate (MTX) in rheumatoid arthritis (RA) patients with an insufficient clinical response to MTX alone. Eleven patients with active RA, despite treatment with MTX, were enrolled and given tacrolimus in combination with MTX for 24 weeks. The primary endpoint was the assessment of clinical improvement using the European League against Rheumatism criteria. Administration of ­tacrolimus to RA patients with an insufficient response to MTX produced significant improvement in the Disease Activity Score 28 after 8–24 weeks. In addition, after 24 weeks, 50% and 25% of patients had achieved moderate and good responses, respectively, and there were ­significant reductions in the Modified Health Assessment Questionnaire, the rheumatoid ­factor and serum matrix metalloproteinase-3 levels. The present preliminary study suggests that low-dose tacrolimus in combination with MTX is well tolerated and provides both clinical and economic benefits.Keywords: rheumatoid arthritis, methotrexate, tacrolimus, DAS28, mHAQ |
| format |
article |
| author |
Takeo Isozaki Michihito Sato Ryo Takahashi et al |
| author_facet |
Takeo Isozaki Michihito Sato Ryo Takahashi et al |
| author_sort |
Takeo Isozaki |
| title |
Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis |
| title_short |
Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis |
| title_full |
Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis |
| title_fullStr |
Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis |
| title_full_unstemmed |
Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis |
| title_sort |
effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/f21b461196624976a00bc73340ebfbde |
| work_keys_str_mv |
AT takeoisozaki effectsoflowdosetacrolimustherapyincombinationwithmethotrexateinpatientswithmethotrexaterefractoryrheumatoidarthritis AT michihitosato effectsoflowdosetacrolimustherapyincombinationwithmethotrexateinpatientswithmethotrexaterefractoryrheumatoidarthritis AT ryotakahashi effectsoflowdosetacrolimustherapyincombinationwithmethotrexateinpatientswithmethotrexaterefractoryrheumatoidarthritis AT etal effectsoflowdosetacrolimustherapyincombinationwithmethotrexateinpatientswithmethotrexaterefractoryrheumatoidarthritis |
| _version_ |
1718398518106783744 |