miR-29b contributes to multiple types of muscle atrophy

Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.

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Autores principales:	Jin Li, Mun Chun Chan, Yan Yu, Yihua Bei, Ping Chen, Qiulian Zhou, Liming Cheng, Lei Chen, Olivia Ziegler, Glenn C. Rowe, Saumya Das, Junjie Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f21c58614d2245499face880f447ae55
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id	oai:doaj.org-article:f21c58614d2245499face880f447ae55
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spelling	oai:doaj.org-article:f21c58614d2245499face880f447ae552021-12-02T14:42:45ZmiR-29b contributes to multiple types of muscle atrophy10.1038/ncomms152012041-1723https://doaj.org/article/f21c58614d2245499face880f447ae552017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15201https://doaj.org/toc/2041-1723Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.Jin LiMun Chun ChanYan YuYihua BeiPing ChenQiulian ZhouLiming ChengLei ChenOlivia ZieglerGlenn C. RoweSaumya DasJunjie XiaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin Li Mun Chun Chan Yan Yu Yihua Bei Ping Chen Qiulian Zhou Liming Cheng Lei Chen Olivia Ziegler Glenn C. Rowe Saumya Das Junjie Xiao miR-29b contributes to multiple types of muscle atrophy
description	Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.
format	article
author	Jin Li Mun Chun Chan Yan Yu Yihua Bei Ping Chen Qiulian Zhou Liming Cheng Lei Chen Olivia Ziegler Glenn C. Rowe Saumya Das Junjie Xiao
author_facet	Jin Li Mun Chun Chan Yan Yu Yihua Bei Ping Chen Qiulian Zhou Liming Cheng Lei Chen Olivia Ziegler Glenn C. Rowe Saumya Das Junjie Xiao
author_sort	Jin Li
title	miR-29b contributes to multiple types of muscle atrophy
title_short	miR-29b contributes to multiple types of muscle atrophy
title_full	miR-29b contributes to multiple types of muscle atrophy
title_fullStr	miR-29b contributes to multiple types of muscle atrophy
title_full_unstemmed	miR-29b contributes to multiple types of muscle atrophy
title_sort	mir-29b contributes to multiple types of muscle atrophy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f21c58614d2245499face880f447ae55
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miR-29b contributes to multiple types of muscle atrophy

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