Crowdsourced mapping of unexplored target space of kinase inhibitors
The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts.
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Nature Portfolio
2021
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oai:doaj.org-article:f21e267a1ae047ee9c1ecdf221b762142021-12-02T15:56:54ZCrowdsourced mapping of unexplored target space of kinase inhibitors10.1038/s41467-021-23165-12041-1723https://doaj.org/article/f21e267a1ae047ee9c1ecdf221b762142021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23165-1https://doaj.org/toc/2041-1723The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts.Anna CichońskaBalaguru RavikumarRobert J. AllawayFangping WanSungjoon ParkOlexandr IsayevShuya LiMichael MasonAndrew LambZiaurrehman TanoliMinji JeonSunkyu KimMariya PopovaStephen CapuzziJianyang ZengKristen DangGregory KoytigerJaewoo KangCarrow I. WellsTimothy M. WillsonThe IDG-DREAM Drug-Kinase Binding Prediction Challenge ConsortiumTudor I. OpreaAvner SchlessingerDavid H. DrewryGustavo StolovitzkyKrister WennerbergJustin GuinneyTero AittokallioNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Anna Cichońska Balaguru Ravikumar Robert J. Allaway Fangping Wan Sungjoon Park Olexandr Isayev Shuya Li Michael Mason Andrew Lamb Ziaurrehman Tanoli Minji Jeon Sunkyu Kim Mariya Popova Stephen Capuzzi Jianyang Zeng Kristen Dang Gregory Koytiger Jaewoo Kang Carrow I. Wells Timothy M. Willson The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium Tudor I. Oprea Avner Schlessinger David H. Drewry Gustavo Stolovitzky Krister Wennerberg Justin Guinney Tero Aittokallio Crowdsourced mapping of unexplored target space of kinase inhibitors |
| description |
The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts. |
| format |
article |
| author |
Anna Cichońska Balaguru Ravikumar Robert J. Allaway Fangping Wan Sungjoon Park Olexandr Isayev Shuya Li Michael Mason Andrew Lamb Ziaurrehman Tanoli Minji Jeon Sunkyu Kim Mariya Popova Stephen Capuzzi Jianyang Zeng Kristen Dang Gregory Koytiger Jaewoo Kang Carrow I. Wells Timothy M. Willson The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium Tudor I. Oprea Avner Schlessinger David H. Drewry Gustavo Stolovitzky Krister Wennerberg Justin Guinney Tero Aittokallio |
| author_facet |
Anna Cichońska Balaguru Ravikumar Robert J. Allaway Fangping Wan Sungjoon Park Olexandr Isayev Shuya Li Michael Mason Andrew Lamb Ziaurrehman Tanoli Minji Jeon Sunkyu Kim Mariya Popova Stephen Capuzzi Jianyang Zeng Kristen Dang Gregory Koytiger Jaewoo Kang Carrow I. Wells Timothy M. Willson The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium Tudor I. Oprea Avner Schlessinger David H. Drewry Gustavo Stolovitzky Krister Wennerberg Justin Guinney Tero Aittokallio |
| author_sort |
Anna Cichońska |
| title |
Crowdsourced mapping of unexplored target space of kinase inhibitors |
| title_short |
Crowdsourced mapping of unexplored target space of kinase inhibitors |
| title_full |
Crowdsourced mapping of unexplored target space of kinase inhibitors |
| title_fullStr |
Crowdsourced mapping of unexplored target space of kinase inhibitors |
| title_full_unstemmed |
Crowdsourced mapping of unexplored target space of kinase inhibitors |
| title_sort |
crowdsourced mapping of unexplored target space of kinase inhibitors |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/f21e267a1ae047ee9c1ecdf221b76214 |
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