Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents

Objective:The aim of this study was to evaluate the efficiency of a buccal spray form of vitamin D compared to single oral dose (stoss therapy) and oral drops therapy in the treatment of vitamin D deficiency.Methods:Ninety healthy children and adolescents (3-18 years) with vitamin D deficiency [seru...

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Autores principales:	Özlem Nalbantoğlu, Sezer Acar, Gülçin Arslan, Özge Köprülü, Behzat Özkan
Formato:	article
Lenguaje:	EN
Publicado:	Galenos Yayincilik 2021
Materias:	vitamin d buccal spray 25-hydroxyvitamin d oral drops Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f2207855074441e884d5c060c9fcaa0e
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spelling	oai:doaj.org-article:f2207855074441e884d5c060c9fcaa0e2021-11-26T06:10:16ZInvestigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents1308-57271308-573510.4274/jcrpe.galenos.2021.2021.0047https://doaj.org/article/f2207855074441e884d5c060c9fcaa0e2021-12-01T00:00:00Z http://www.jcrpe.org/archives/archive-detail/article-preview/nvestigating-the-efficiency-of-vitamin-d-administr/47685 https://doaj.org/toc/1308-5727https://doaj.org/toc/1308-5735Objective:The aim of this study was to evaluate the efficiency of a buccal spray form of vitamin D compared to single oral dose (stoss therapy) and oral drops therapy in the treatment of vitamin D deficiency.Methods:Ninety healthy children and adolescents (3-18 years) with vitamin D deficiency [serum level of 25-hydroxyvitamin D (25(OH) D) <12 ng/mL] were randomized to receive vitamin D3 buccal spray (2000 U, n=30, group 1) for six weeks, oral drops (2000 U, n=30, group 2) for six weeks and a single oral dose (300 000 U) vitamin D3 (n=30, group 3). Serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone and 25(OH)D levels of the patients were measured at baseline and after the treatment on the 42nd day.Results:All three groups had a significant increase in serum 25(OH)D concentrations (p<0.001). In group 1, baseline mean 25(OH)D was 8.0±0.41 ng/mL, which rose to 22.1 (17.8-28.2) ng/mL after treatment with a mean increase of 15.6±1.3 ng/mL. Similarly in group 2, baseline, post-treatment and mean increase in 25(OH)D concentrations were 7.9±0.45 ng/mL, 24.4 (20.6-29.6) ng/mL and 17.3±1.1 ng/mL while for group 3 these values were 7.6±0.47 ng/mL, 40.3 (29.4-58.4) ng/mL and 34.3±3.2 ng/mL, respectively.Conclusion:We conclude that vitamin D3 supplementation with buccal spray and oral drops is equally effective in terms of raising vitamin D concentrations in short-term treatment of vitamin D deficiency.Özlem NalbantoğluSezer AcarGülçin ArslanÖzge KöprülüBehzat ÖzkanGalenos Yayincilikarticlevitamin dbuccal spray25-hydroxyvitamin doral dropsPediatricsRJ1-570Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENJCRPE, Vol 13, Iss 4, Pp 426-432 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d buccal spray 25-hydroxyvitamin d oral drops Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	vitamin d buccal spray 25-hydroxyvitamin d oral drops Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Özlem Nalbantoğlu Sezer Acar Gülçin Arslan Özge Köprülü Behzat Özkan Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents
description	Objective:The aim of this study was to evaluate the efficiency of a buccal spray form of vitamin D compared to single oral dose (stoss therapy) and oral drops therapy in the treatment of vitamin D deficiency.Methods:Ninety healthy children and adolescents (3-18 years) with vitamin D deficiency [serum level of 25-hydroxyvitamin D (25(OH) D) <12 ng/mL] were randomized to receive vitamin D3 buccal spray (2000 U, n=30, group 1) for six weeks, oral drops (2000 U, n=30, group 2) for six weeks and a single oral dose (300 000 U) vitamin D3 (n=30, group 3). Serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone and 25(OH)D levels of the patients were measured at baseline and after the treatment on the 42nd day.Results:All three groups had a significant increase in serum 25(OH)D concentrations (p<0.001). In group 1, baseline mean 25(OH)D was 8.0±0.41 ng/mL, which rose to 22.1 (17.8-28.2) ng/mL after treatment with a mean increase of 15.6±1.3 ng/mL. Similarly in group 2, baseline, post-treatment and mean increase in 25(OH)D concentrations were 7.9±0.45 ng/mL, 24.4 (20.6-29.6) ng/mL and 17.3±1.1 ng/mL while for group 3 these values were 7.6±0.47 ng/mL, 40.3 (29.4-58.4) ng/mL and 34.3±3.2 ng/mL, respectively.Conclusion:We conclude that vitamin D3 supplementation with buccal spray and oral drops is equally effective in terms of raising vitamin D concentrations in short-term treatment of vitamin D deficiency.
format	article
author	Özlem Nalbantoğlu Sezer Acar Gülçin Arslan Özge Köprülü Behzat Özkan
author_facet	Özlem Nalbantoğlu Sezer Acar Gülçin Arslan Özge Köprülü Behzat Özkan
author_sort	Özlem Nalbantoğlu
title	Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents
title_short	Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents
title_full	Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents
title_fullStr	Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents
title_full_unstemmed	Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents
title_sort	investigating the efficiency of vitamin d administration with buccal spray in the treatment of vitamin d deficiency in children and adolescents
publisher	Galenos Yayincilik
publishDate	2021
url	https://doaj.org/article/f2207855074441e884d5c060c9fcaa0e
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Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents

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