Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

Haematopoietic stem and progenitor cells (HSPCs) produce all blood lineages and arise from the haemogenic endothelium (HE) during embryogenesis. Here the authors show that genes specific to cilia formation are required for HSPC development in the HE in zebrafish through transduction of Notch signal.

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Autores principales:	Zhibin Liu, Haiqing Tu, Yunsi Kang, Yuanyuan Xue, Dongyuan Ma, Chengtian Zhao, Huiyan Li, Lu Wang, Feng Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2213d7514cf44c29cd6ceee2cafd23a
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spelling	oai:doaj.org-article:f2213d7514cf44c29cd6ceee2cafd23a2021-12-02T16:50:56ZPrimary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish10.1038/s41467-019-09403-72041-1723https://doaj.org/article/f2213d7514cf44c29cd6ceee2cafd23a2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09403-7https://doaj.org/toc/2041-1723Haematopoietic stem and progenitor cells (HSPCs) produce all blood lineages and arise from the haemogenic endothelium (HE) during embryogenesis. Here the authors show that genes specific to cilia formation are required for HSPC development in the HE in zebrafish through transduction of Notch signal.Zhibin LiuHaiqing TuYunsi KangYuanyuan XueDongyuan MaChengtian ZhaoHuiyan LiLu WangFeng LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhibin Liu Haiqing Tu Yunsi Kang Yuanyuan Xue Dongyuan Ma Chengtian Zhao Huiyan Li Lu Wang Feng Liu Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish
description	Haematopoietic stem and progenitor cells (HSPCs) produce all blood lineages and arise from the haemogenic endothelium (HE) during embryogenesis. Here the authors show that genes specific to cilia formation are required for HSPC development in the HE in zebrafish through transduction of Notch signal.
format	article
author	Zhibin Liu Haiqing Tu Yunsi Kang Yuanyuan Xue Dongyuan Ma Chengtian Zhao Huiyan Li Lu Wang Feng Liu
author_facet	Zhibin Liu Haiqing Tu Yunsi Kang Yuanyuan Xue Dongyuan Ma Chengtian Zhao Huiyan Li Lu Wang Feng Liu
author_sort	Zhibin Liu
title	Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish
title_short	Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish
title_full	Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish
title_fullStr	Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish
title_full_unstemmed	Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish
title_sort	primary cilia regulate hematopoietic stem and progenitor cell specification through notch signaling in zebrafish
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f2213d7514cf44c29cd6ceee2cafd23a
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_version_	1718383014995558400

Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

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