The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders

Jacob Peedicayil Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaCorrespondence: Jacob PeedicayilDepartment of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaTel/Fax +91-0416-2284237Email jpeedi@cmcvellore.a...

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Autor principal:	Peedicayil J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	anxiety disorders epigenetic histone deacetylase histone deacetylase inhibitor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f22206b2cc4d4d7ebbf4f1ff9f66e049
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spelling	oai:doaj.org-article:f22206b2cc4d4d7ebbf4f1ff9f66e0492021-12-02T13:16:17ZThe Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders1178-2021https://doaj.org/article/f22206b2cc4d4d7ebbf4f1ff9f66e0492020-03-01T00:00:00Zhttps://www.dovepress.com/the-potential-role-of-epigenetic-drugs-in-the-treatment-of-anxiety-dis-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jacob Peedicayil Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaCorrespondence: Jacob PeedicayilDepartment of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaTel/Fax +91-0416-2284237Email jpeedi@cmcvellore.ac.inAbstract: There is increasing evidence that abnormalities in epigenetic mechanisms of gene expression contribute to the pathogenesis of anxiety disorders (ADs). This article discusses the role of epigenetic mechanisms of gene expression in the pathogenesis of ADs. It also discusses the data so far obtained from preclinical and clinical trials on the use of epigenetic drugs for treating ADs. Most drug trials investigating the use of epigenetic drugs for treating ADs have used histone deacetylase inhibitors (HDACi). HDACi are showing favorable results in both preclinical and clinical drug trials for treating ADs. However, at present the mode of action of HDACi in ADs is not clear. More work needs to be done to elucidate how epigenetic dysregulation contributes to the pathogenesis of ADs. More work also needs to be done on the mode of action of HDACi in alleviating the signs and symptoms of ADs.Keywords: anxiety disorders, epigenetic, histone deacetylase, histone deacetylase inhibitorPeedicayil JDove Medical Pressarticleanxiety disordersepigenetichistone deacetylasehistone deacetylase inhibitorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 597-606 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxiety disorders epigenetic histone deacetylase histone deacetylase inhibitor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	anxiety disorders epigenetic histone deacetylase histone deacetylase inhibitor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Peedicayil J The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders
description	Jacob Peedicayil Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaCorrespondence: Jacob PeedicayilDepartment of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaTel/Fax +91-0416-2284237Email jpeedi@cmcvellore.ac.inAbstract: There is increasing evidence that abnormalities in epigenetic mechanisms of gene expression contribute to the pathogenesis of anxiety disorders (ADs). This article discusses the role of epigenetic mechanisms of gene expression in the pathogenesis of ADs. It also discusses the data so far obtained from preclinical and clinical trials on the use of epigenetic drugs for treating ADs. Most drug trials investigating the use of epigenetic drugs for treating ADs have used histone deacetylase inhibitors (HDACi). HDACi are showing favorable results in both preclinical and clinical drug trials for treating ADs. However, at present the mode of action of HDACi in ADs is not clear. More work needs to be done to elucidate how epigenetic dysregulation contributes to the pathogenesis of ADs. More work also needs to be done on the mode of action of HDACi in alleviating the signs and symptoms of ADs.Keywords: anxiety disorders, epigenetic, histone deacetylase, histone deacetylase inhibitor
format	article
author	Peedicayil J
author_facet	Peedicayil J
author_sort	Peedicayil J
title	The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders
title_short	The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders
title_full	The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders
title_fullStr	The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders
title_full_unstemmed	The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders
title_sort	potential role of epigenetic drugs in the treatment of anxiety disorders
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f22206b2cc4d4d7ebbf4f1ff9f66e049
work_keys_str_mv	AT peedicayilj thepotentialroleofepigeneticdrugsinthetreatmentofanxietydisorders AT peedicayilj potentialroleofepigeneticdrugsinthetreatmentofanxietydisorders
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The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders

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