In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery

Diana Urbaneja,1 Antonio Morilla-Grasa,1 Elisa Jimenez,1 Judith Montemayor,1 Nuria Marcobal,2 Carme Aragay,2 Celia Gurdiel,2 Marta Armillas,2 Pere Ortiz,2 Alfonso Antón1–3 1Department of Ophthalmology, Institut Català de Retina, Barcelona, Spain; 2Department of Ophth...

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Autores principales:	Urbaneja D, Morilla-Grasa A, Jimenez E, Montemayor J, Marcobal N, Aragay C, Gurdiel C, Ortiz P, Antón A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	glaucoma absorbable gelatin sponges mitomycin polyvinyl alcohol. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f224fe794085443ba612d2c8cfd0c219
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spelling	oai:doaj.org-article:f224fe794085443ba612d2c8cfd0c2192021-12-02T01:30:10ZIn vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery1177-5483https://doaj.org/article/f224fe794085443ba612d2c8cfd0c2192016-04-01T00:00:00Zhttps://www.dovepress.com/in-vitro-mitomycin-c-absorption-and-delivery-with-different-sponge-mat-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Diana Urbaneja,1 Antonio Morilla-Grasa,1 Elisa Jimenez,1 Judith Montemayor,1 Nuria Marcobal,2 Carme Aragay,2 Celia Gurdiel,2 Marta Armillas,2 Pere Ortiz,2 Alfonso Antón1–3 1Department of Ophthalmology, Institut Català de Retina, Barcelona, Spain; 2Department of Ophthalmology, Hospital Ntra Sra De La Esperanza - Parc de Salut Mar, Barcelona, Spain; 3Universitat Internacional de Catalunya, Barcelona, Spain Purpose: The purpose of this study is to evaluate and compare mitomycin C (MMC) absorption and delivery in different materials used in filtering surgery.Methods: This is an in vitro study comparing polyvinyl alcohol triangular sponges (TS6, TS8), polyvinyl alcohol fluid wicks (EFW), and absorbable gelatin sponges (AGS3, AGS5), from which five different types of transport units were obtained. Seven pieces of sponge of each transport unit type were obtained as follows: two transverse strips were obtained at 6 and 8 mm from the apex of TS and divided into three equal pieces; 4×4 mm pieces of EFW; 3×3 and 5×5 mm pieces of absorbable gelatin sponges were cut. Filter paper was placed on a precision scale (0.01 mg). The seven sponge pieces of each type were weighed three times consecutively in dry and wet states, the latter after immersion for 15 seconds in 0.2 mg/mL MMC. The difference between the weights of the dry and wet filter paper at the end of each measurement sequence was also calculated and considered as an estimate of the amount of mitomycin delivered.Results: The amounts of MMC absorbed by each transport unit were as follows: (mean ± standard deviation) 27.43±5.13 for TS6, 31.91±6.63 for TS8, 15.96±2.23 for EFW, 17.96±2.05 for AGS3, and 33.81±2.05 for AGS5. The amounts of MMC delivered to the filter paper were as follows: 21.70±2.84 for TS6, 23.83±4.03 for TS8, 12.93±1.75 for EFW, 14.69±1.79 for AGS3, and 27.30±1.58 for AGS5.Conclusion: Percentage MMC delivered was similar for all materials, but there was a tendency for greater delivery using larger sponges and greater homogeneity in delivery with AGS5. No statistical differences were found in percentage delivered by the different transport materials.Keywords: glaucoma, absorbable gelatin sponges, mitomycin, polyvinyl alcohol Urbaneja DMorilla-Grasa AJimenez EMontemayor JMarcobal NAragay CGurdiel COrtiz PAntón ADove Medical Pressarticleglaucomaabsorbable gelatin spongesmitomycinpolyvinyl alcohol.OphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 665-669 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma absorbable gelatin sponges mitomycin polyvinyl alcohol. Ophthalmology RE1-994
spellingShingle	glaucoma absorbable gelatin sponges mitomycin polyvinyl alcohol. Ophthalmology RE1-994 Urbaneja D Morilla-Grasa A Jimenez E Montemayor J Marcobal N Aragay C Gurdiel C Ortiz P Antón A In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery
description	Diana Urbaneja,1 Antonio Morilla-Grasa,1 Elisa Jimenez,1 Judith Montemayor,1 Nuria Marcobal,2 Carme Aragay,2 Celia Gurdiel,2 Marta Armillas,2 Pere Ortiz,2 Alfonso Antón1–3 1Department of Ophthalmology, Institut Català de Retina, Barcelona, Spain; 2Department of Ophthalmology, Hospital Ntra Sra De La Esperanza - Parc de Salut Mar, Barcelona, Spain; 3Universitat Internacional de Catalunya, Barcelona, Spain Purpose: The purpose of this study is to evaluate and compare mitomycin C (MMC) absorption and delivery in different materials used in filtering surgery.Methods: This is an in vitro study comparing polyvinyl alcohol triangular sponges (TS6, TS8), polyvinyl alcohol fluid wicks (EFW), and absorbable gelatin sponges (AGS3, AGS5), from which five different types of transport units were obtained. Seven pieces of sponge of each transport unit type were obtained as follows: two transverse strips were obtained at 6 and 8 mm from the apex of TS and divided into three equal pieces; 4×4 mm pieces of EFW; 3×3 and 5×5 mm pieces of absorbable gelatin sponges were cut. Filter paper was placed on a precision scale (0.01 mg). The seven sponge pieces of each type were weighed three times consecutively in dry and wet states, the latter after immersion for 15 seconds in 0.2 mg/mL MMC. The difference between the weights of the dry and wet filter paper at the end of each measurement sequence was also calculated and considered as an estimate of the amount of mitomycin delivered.Results: The amounts of MMC absorbed by each transport unit were as follows: (mean ± standard deviation) 27.43±5.13 for TS6, 31.91±6.63 for TS8, 15.96±2.23 for EFW, 17.96±2.05 for AGS3, and 33.81±2.05 for AGS5. The amounts of MMC delivered to the filter paper were as follows: 21.70±2.84 for TS6, 23.83±4.03 for TS8, 12.93±1.75 for EFW, 14.69±1.79 for AGS3, and 27.30±1.58 for AGS5.Conclusion: Percentage MMC delivered was similar for all materials, but there was a tendency for greater delivery using larger sponges and greater homogeneity in delivery with AGS5. No statistical differences were found in percentage delivered by the different transport materials.Keywords: glaucoma, absorbable gelatin sponges, mitomycin, polyvinyl alcohol
format	article
author	Urbaneja D Morilla-Grasa A Jimenez E Montemayor J Marcobal N Aragay C Gurdiel C Ortiz P Antón A
author_facet	Urbaneja D Morilla-Grasa A Jimenez E Montemayor J Marcobal N Aragay C Gurdiel C Ortiz P Antón A
author_sort	Urbaneja D
title	In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery
title_short	In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery
title_full	In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery
title_fullStr	In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery
title_full_unstemmed	In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery
title_sort	in vitro mitomycin c absorption and delivery with different sponge materials used in filtering surgery
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f224fe794085443ba612d2c8cfd0c219
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In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery

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