Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER

Yajun Li,1 Kailin Chen,2 Chaohui Zuo,3 Ruolan Zeng,1 Yizi He,1 Xiaoyan Chen,4 Ling Xiao,5 Hui Zhou1 1Department of Lymphoma and Hematology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, People’s Republic of...

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Autores principales:	Li Y, Chen K, Zuo C, Zeng R, He Y, Chen X, Xiao L, Zhou H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hepatosplenic t cell lymphoma survival seer treatment Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f22510423a2241dd938816e2010dd33a
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id	oai:doaj.org-article:f22510423a2241dd938816e2010dd33a
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatosplenic t cell lymphoma survival seer treatment Medicine (General) R5-920
spellingShingle	hepatosplenic t cell lymphoma survival seer treatment Medicine (General) R5-920 Li Y Chen K Zuo C Zeng R He Y Chen X Xiao L Zhou H Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER
description	Yajun Li,1 Kailin Chen,2 Chaohui Zuo,3 Ruolan Zeng,1 Yizi He,1 Xiaoyan Chen,4 Ling Xiao,5 Hui Zhou1 1Department of Lymphoma and Hematology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 2Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, 510060, People’s Republic of China; 3Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, Affiliated Cancer Hospital of Xiangya Medical School and Hunan Cancer Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 4Department of Pathology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 5Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, People’s Republic of ChinaCorrespondence: Hui ZhouDepartment of Lymphoma and Hematology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Changsha, Hunan, 410013, People’s Republic of ChinaFax +8673189762282Email zhouhui@hnca.org.cnChaohui ZuoDepartment of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer Hospital, Central South University, 283 Tongzipo Road, Changsha, Hunan, 410013, People’s Republic of ChinaFax +8673189762142Email zuochaohui@hnca.org.cnPurpose: Hepatosplenic T cell lymphoma (HSTCL) is a rare tumor that lacks data to guide management decisions. To shed light on the nature and therapy of the entity, we conducted this study.Patients and Methods: We retrospectively reviewed patients diagnosed with HSTCL between 1975 and 2016 in the Surveillance, Epidemiology, and End Results (SEER) database to analyze the clinical characteristics and survival outcome compared with PTCL-NOS and ALK+ ALCL.Results: A total of 123 HSTCLs were included in the analysis. Most patients were aged ≤ 60 years (81.3%) and had a male predominance (69.1%). Organs with lymphoma infiltration of HSTCL were more common in the spleen (98.4%). The 1-year, 3-year, and 5-year overall survival (OS) rates in the entire HSTCL cohort were 56.9% (95% CI, 47.5– 66.3%), 37.6% (95% CI, 28.0– 47.2%), and 31.6.0% (95% CI, 22.2– 41.0%), respectively. The overall survival (OS) of HSTCL patients was similar to that of PTCL-NOS patients (P = 0.128) but worse than that of patients with ALK+ ALCL (P < 0.001). The disease-specific survival (DSS) of HSTCL patients was worse than that of PTCL-NOS and ALK+ ALCL patients (P < 0.05). The same tendency was found in the matched data set. Cox regression analyses indicated that the use of chemotherapy combined with topical treatment may improve the survival of patients with HSTCL.Conclusion: A higher proportion of young patients and a strong male predominance were found in HSTCL. Chemotherapy combined with topical treatment may be an optional regimen. Further studies are needed to intensify efforts in dealing with this rare but unfavorable disease.Keywords: hepatosplenic T cell lymphoma, survival, SEER, treatment
format	article
author	Li Y Chen K Zuo C Zeng R He Y Chen X Xiao L Zhou H
author_facet	Li Y Chen K Zuo C Zeng R He Y Chen X Xiao L Zhou H
author_sort	Li Y
title	Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER
title_short	Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER
title_full	Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER
title_fullStr	Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER
title_full_unstemmed	Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER
title_sort	survival analysis of hepatosplenic t cell lymphoma: a population-based study using seer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f22510423a2241dd938816e2010dd33a
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spelling	oai:doaj.org-article:f22510423a2241dd938816e2010dd33a2021-11-18T19:40:25ZSurvival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER1178-7074https://doaj.org/article/f22510423a2241dd938816e2010dd33a2021-11-01T00:00:00Zhttps://www.dovepress.com/survival-analysis-of-hepatosplenic-t-cell-lymphoma-a-population-based--peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Yajun Li,1 Kailin Chen,2 Chaohui Zuo,3 Ruolan Zeng,1 Yizi He,1 Xiaoyan Chen,4 Ling Xiao,5 Hui Zhou1 1Department of Lymphoma and Hematology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 2Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, 510060, People’s Republic of China; 3Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, Affiliated Cancer Hospital of Xiangya Medical School and Hunan Cancer Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 4Department of Pathology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 5Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, People’s Republic of ChinaCorrespondence: Hui ZhouDepartment of Lymphoma and Hematology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Changsha, Hunan, 410013, People’s Republic of ChinaFax +8673189762282Email zhouhui@hnca.org.cnChaohui ZuoDepartment of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer Hospital, Central South University, 283 Tongzipo Road, Changsha, Hunan, 410013, People’s Republic of ChinaFax +8673189762142Email zuochaohui@hnca.org.cnPurpose: Hepatosplenic T cell lymphoma (HSTCL) is a rare tumor that lacks data to guide management decisions. To shed light on the nature and therapy of the entity, we conducted this study.Patients and Methods: We retrospectively reviewed patients diagnosed with HSTCL between 1975 and 2016 in the Surveillance, Epidemiology, and End Results (SEER) database to analyze the clinical characteristics and survival outcome compared with PTCL-NOS and ALK+ ALCL.Results: A total of 123 HSTCLs were included in the analysis. Most patients were aged ≤ 60 years (81.3%) and had a male predominance (69.1%). Organs with lymphoma infiltration of HSTCL were more common in the spleen (98.4%). The 1-year, 3-year, and 5-year overall survival (OS) rates in the entire HSTCL cohort were 56.9% (95% CI, 47.5– 66.3%), 37.6% (95% CI, 28.0– 47.2%), and 31.6.0% (95% CI, 22.2– 41.0%), respectively. The overall survival (OS) of HSTCL patients was similar to that of PTCL-NOS patients (P = 0.128) but worse than that of patients with ALK+ ALCL (P < 0.001). The disease-specific survival (DSS) of HSTCL patients was worse than that of PTCL-NOS and ALK+ ALCL patients (P < 0.05). The same tendency was found in the matched data set. Cox regression analyses indicated that the use of chemotherapy combined with topical treatment may improve the survival of patients with HSTCL.Conclusion: A higher proportion of young patients and a strong male predominance were found in HSTCL. Chemotherapy combined with topical treatment may be an optional regimen. Further studies are needed to intensify efforts in dealing with this rare but unfavorable disease.Keywords: hepatosplenic T cell lymphoma, survival, SEER, treatmentLi YChen KZuo CZeng RHe YChen XXiao LZhou HDove Medical Pressarticlehepatosplenic t cell lymphomasurvivalseertreatmentMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8399-8411 (2021)

Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER

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