The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?

Abstract Objectives The natural history of sporadic non‐ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods This is a single‐center retrospective study...

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Autores principales:	Yoshiki Sakaguchi, Yosuke Tsuji, Tetsuo Ushiku, Dai Kubota, Junichi Sato, Miho Obata, Rina Cho, Sayaka Nagao, Nobuyuki Sakuma, Naoki Tamura, Yuko Miura, Kazushi Fukagawa, Daisuke Ohki, Hiroya Mizutani, Chihiro Takeuchi, Yu Takahashi, Chihiro Minatsuki, Keiko Niimi, Nobutake Yamamichi, Kazuhiko Koike
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	natural history sporadic non‐ampullary duodenal epithelial tumor tumor progression Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/f22a118eb5a040728ef88f69fe3f2c2b
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spelling	oai:doaj.org-article:f22a118eb5a040728ef88f69fe3f2c2b2021-11-16T19:20:28ZThe natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?2692-460910.1002/deo2.9https://doaj.org/article/f22a118eb5a040728ef88f69fe3f2c2b2021-04-01T00:00:00Zhttps://doi.org/10.1002/deo2.9https://doaj.org/toc/2692-4609Abstract Objectives The natural history of sporadic non‐ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods This is a single‐center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed‐up with upper gastrointestinal endoscopy for more than 6 months. Results During a follow‐up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer.Yoshiki SakaguchiYosuke TsujiTetsuo UshikuDai KubotaJunichi SatoMiho ObataRina ChoSayaka NagaoNobuyuki SakumaNaoki TamuraYuko MiuraKazushi FukagawaDaisuke OhkiHiroya MizutaniChihiro TakeuchiYu TakahashiChihiro MinatsukiKeiko NiimiNobutake YamamichiKazuhiko KoikeWileyarticlenatural historysporadic non‐ampullary duodenal epithelial tumortumor progressionDiseases of the digestive system. GastroenterologyRC799-869ENDEN Open, Vol 1, Iss 1, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	natural history sporadic non‐ampullary duodenal epithelial tumor tumor progression Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	natural history sporadic non‐ampullary duodenal epithelial tumor tumor progression Diseases of the digestive system. Gastroenterology RC799-869 Yoshiki Sakaguchi Yosuke Tsuji Tetsuo Ushiku Dai Kubota Junichi Sato Miho Obata Rina Cho Sayaka Nagao Nobuyuki Sakuma Naoki Tamura Yuko Miura Kazushi Fukagawa Daisuke Ohki Hiroya Mizutani Chihiro Takeuchi Yu Takahashi Chihiro Minatsuki Keiko Niimi Nobutake Yamamichi Kazuhiko Koike The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?
description	Abstract Objectives The natural history of sporadic non‐ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods This is a single‐center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed‐up with upper gastrointestinal endoscopy for more than 6 months. Results During a follow‐up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer.
format	article
author	Yoshiki Sakaguchi Yosuke Tsuji Tetsuo Ushiku Dai Kubota Junichi Sato Miho Obata Rina Cho Sayaka Nagao Nobuyuki Sakuma Naoki Tamura Yuko Miura Kazushi Fukagawa Daisuke Ohki Hiroya Mizutani Chihiro Takeuchi Yu Takahashi Chihiro Minatsuki Keiko Niimi Nobutake Yamamichi Kazuhiko Koike
author_facet	Yoshiki Sakaguchi Yosuke Tsuji Tetsuo Ushiku Dai Kubota Junichi Sato Miho Obata Rina Cho Sayaka Nagao Nobuyuki Sakuma Naoki Tamura Yuko Miura Kazushi Fukagawa Daisuke Ohki Hiroya Mizutani Chihiro Takeuchi Yu Takahashi Chihiro Minatsuki Keiko Niimi Nobutake Yamamichi Kazuhiko Koike
author_sort	Yoshiki Sakaguchi
title	The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?
title_short	The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?
title_full	The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?
title_fullStr	The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?
title_full_unstemmed	The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?
title_sort	natural history of sporadic non‐ampullary duodenal epithelial tumors: can we wait and see?
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/f22a118eb5a040728ef88f69fe3f2c2b
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The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?

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