Combating subclonal evolution of resistant cancer phenotypes

In metastatic breast cancer, subclonal evolution can drive drug resistance. Here, the authors genetically and transcriptionally follow the evolution of four breast cancers over time and treatment, and suggest a phenotype-targeted treatment strategy to adapt to cancer as it evolves.

Guardado en:

Detalles Bibliográficos
Autores principales:	Samuel W. Brady, Jasmine A. McQuerry, Yi Qiao, Stephen R. Piccolo, Gajendra Shrestha, David F. Jenkins, Ryan M. Layer, Brent S. Pedersen, Ryan H. Miller, Amanda Esch, Sara R. Selitsky, Joel S. Parker, Layla A. Anderson, Brian K. Dalley, Rachel E. Factor, Chakravarthy B. Reddy, Jonathan P. Boltax, Dean Y. Li, Philip J. Moos, Joe W. Gray, Laura M. Heiser, Saundra S. Buys, Adam L. Cohen, W. Evan Johnson, Aaron R. Quinlan, Gabor Marth, Theresa L. Werner, Andrea H. Bild
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f22c7e1eec644bd49c349e24a268484e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f22c7e1eec644bd49c349e24a268484e
record_format	dspace
spelling	oai:doaj.org-article:f22c7e1eec644bd49c349e24a268484e2021-12-02T15:39:04ZCombating subclonal evolution of resistant cancer phenotypes10.1038/s41467-017-01174-32041-1723https://doaj.org/article/f22c7e1eec644bd49c349e24a268484e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01174-3https://doaj.org/toc/2041-1723In metastatic breast cancer, subclonal evolution can drive drug resistance. Here, the authors genetically and transcriptionally follow the evolution of four breast cancers over time and treatment, and suggest a phenotype-targeted treatment strategy to adapt to cancer as it evolves.Samuel W. BradyJasmine A. McQuerryYi QiaoStephen R. PiccoloGajendra ShresthaDavid F. JenkinsRyan M. LayerBrent S. PedersenRyan H. MillerAmanda EschSara R. SelitskyJoel S. ParkerLayla A. AndersonBrian K. DalleyRachel E. FactorChakravarthy B. ReddyJonathan P. BoltaxDean Y. LiPhilip J. MoosJoe W. GrayLaura M. HeiserSaundra S. BuysAdam L. CohenW. Evan JohnsonAaron R. QuinlanGabor MarthTheresa L. WernerAndrea H. BildNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel W. Brady Jasmine A. McQuerry Yi Qiao Stephen R. Piccolo Gajendra Shrestha David F. Jenkins Ryan M. Layer Brent S. Pedersen Ryan H. Miller Amanda Esch Sara R. Selitsky Joel S. Parker Layla A. Anderson Brian K. Dalley Rachel E. Factor Chakravarthy B. Reddy Jonathan P. Boltax Dean Y. Li Philip J. Moos Joe W. Gray Laura M. Heiser Saundra S. Buys Adam L. Cohen W. Evan Johnson Aaron R. Quinlan Gabor Marth Theresa L. Werner Andrea H. Bild Combating subclonal evolution of resistant cancer phenotypes
description	In metastatic breast cancer, subclonal evolution can drive drug resistance. Here, the authors genetically and transcriptionally follow the evolution of four breast cancers over time and treatment, and suggest a phenotype-targeted treatment strategy to adapt to cancer as it evolves.
format	article
author	Samuel W. Brady Jasmine A. McQuerry Yi Qiao Stephen R. Piccolo Gajendra Shrestha David F. Jenkins Ryan M. Layer Brent S. Pedersen Ryan H. Miller Amanda Esch Sara R. Selitsky Joel S. Parker Layla A. Anderson Brian K. Dalley Rachel E. Factor Chakravarthy B. Reddy Jonathan P. Boltax Dean Y. Li Philip J. Moos Joe W. Gray Laura M. Heiser Saundra S. Buys Adam L. Cohen W. Evan Johnson Aaron R. Quinlan Gabor Marth Theresa L. Werner Andrea H. Bild
author_facet	Samuel W. Brady Jasmine A. McQuerry Yi Qiao Stephen R. Piccolo Gajendra Shrestha David F. Jenkins Ryan M. Layer Brent S. Pedersen Ryan H. Miller Amanda Esch Sara R. Selitsky Joel S. Parker Layla A. Anderson Brian K. Dalley Rachel E. Factor Chakravarthy B. Reddy Jonathan P. Boltax Dean Y. Li Philip J. Moos Joe W. Gray Laura M. Heiser Saundra S. Buys Adam L. Cohen W. Evan Johnson Aaron R. Quinlan Gabor Marth Theresa L. Werner Andrea H. Bild
author_sort	Samuel W. Brady
title	Combating subclonal evolution of resistant cancer phenotypes
title_short	Combating subclonal evolution of resistant cancer phenotypes
title_full	Combating subclonal evolution of resistant cancer phenotypes
title_fullStr	Combating subclonal evolution of resistant cancer phenotypes
title_full_unstemmed	Combating subclonal evolution of resistant cancer phenotypes
title_sort	combating subclonal evolution of resistant cancer phenotypes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f22c7e1eec644bd49c349e24a268484e
work_keys_str_mv	AT samuelwbrady combatingsubclonalevolutionofresistantcancerphenotypes AT jasmineamcquerry combatingsubclonalevolutionofresistantcancerphenotypes AT yiqiao combatingsubclonalevolutionofresistantcancerphenotypes AT stephenrpiccolo combatingsubclonalevolutionofresistantcancerphenotypes AT gajendrashrestha combatingsubclonalevolutionofresistantcancerphenotypes AT davidfjenkins combatingsubclonalevolutionofresistantcancerphenotypes AT ryanmlayer combatingsubclonalevolutionofresistantcancerphenotypes AT brentspedersen combatingsubclonalevolutionofresistantcancerphenotypes AT ryanhmiller combatingsubclonalevolutionofresistantcancerphenotypes AT amandaesch combatingsubclonalevolutionofresistantcancerphenotypes AT sararselitsky combatingsubclonalevolutionofresistantcancerphenotypes AT joelsparker combatingsubclonalevolutionofresistantcancerphenotypes AT laylaaanderson combatingsubclonalevolutionofresistantcancerphenotypes AT briankdalley combatingsubclonalevolutionofresistantcancerphenotypes AT rachelefactor combatingsubclonalevolutionofresistantcancerphenotypes AT chakravarthybreddy combatingsubclonalevolutionofresistantcancerphenotypes AT jonathanpboltax combatingsubclonalevolutionofresistantcancerphenotypes AT deanyli combatingsubclonalevolutionofresistantcancerphenotypes AT philipjmoos combatingsubclonalevolutionofresistantcancerphenotypes AT joewgray combatingsubclonalevolutionofresistantcancerphenotypes AT lauramheiser combatingsubclonalevolutionofresistantcancerphenotypes AT saundrasbuys combatingsubclonalevolutionofresistantcancerphenotypes AT adamlcohen combatingsubclonalevolutionofresistantcancerphenotypes AT wevanjohnson combatingsubclonalevolutionofresistantcancerphenotypes AT aaronrquinlan combatingsubclonalevolutionofresistantcancerphenotypes AT gabormarth combatingsubclonalevolutionofresistantcancerphenotypes AT theresalwerner combatingsubclonalevolutionofresistantcancerphenotypes AT andreahbild combatingsubclonalevolutionofresistantcancerphenotypes
_version_	1718386027217813504

Combating subclonal evolution of resistant cancer phenotypes

Ejemplares similares