SpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure

Abstract The high-flow nasal cannula (HFNC) is a useful treatment modality for acute hypoxemic respiratory failure (AHRF) in children. We compared the ability of the oxygen saturation to fraction of inspired oxygen ratio (S/F) and arterial oxygen partial pressure to fraction of inspired oxygen ratio...

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Autores principales:	Ga Eun Kim, Sun Ha Choi, Mireu Park, Jae Hwa Jung, Myeongjee Lee, Soo Yeon Kim, Min Jung Kim, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2300af7058c4adfbf95ef13cf82f2ee
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spelling	oai:doaj.org-article:f2300af7058c4adfbf95ef13cf82f2ee2021-12-02T14:34:03ZSpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure10.1038/s41598-021-92893-72045-2322https://doaj.org/article/f2300af7058c4adfbf95ef13cf82f2ee2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92893-7https://doaj.org/toc/2045-2322Abstract The high-flow nasal cannula (HFNC) is a useful treatment modality for acute hypoxemic respiratory failure (AHRF) in children. We compared the ability of the oxygen saturation to fraction of inspired oxygen ratio (S/F) and arterial oxygen partial pressure to fraction of inspired oxygen ratio (P/F) to predict HFNC outcomes in children with AHRF. This study included children treated with HFNC due to AHRF from April 2013 to March 2019 at the Severance Children’s Hospital. HFNC failure was defined as the need for mechanical ventilation. Trends of S/F and P/F during HFNC were analyzed. To predict HFNC outcomes, a nomogram was constructed based on predictive factors. A total of 139 patients with arterial blood gas data were included in the S/F and P/F analyses. S/F < 230 at initiation showed high prediction accuracy for HFNC failure (area under the receiver operating characteristic curve: 0.751). Univariate analyses identified S/F < 230 at HFNC initiation and < 200 at 2 h (odds ratio [OR] 12.83, 95% CI 5.06–35.84), and hemato-oncologic disease (OR 3.79, 95% CI 1.12–12.78) as significant predictive factors of HFNC failure. The constructed nomogram had a highly predictive performance, with a concordance index of 0.765 and 0.831 for the exploratory and validation groups, respectively. S/F may be used as a predictor of HFNC outcomes. Our nomogram with S/F for HFNC failure within 2 h may prevent delayed intubation in children with AHRF.Ga Eun KimSun Ha ChoiMireu ParkJae Hwa JungMyeongjee LeeSoo Yeon KimMin Jung KimYoon Hee KimKyung Won KimMyung Hyun SohnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ga Eun Kim Sun Ha Choi Mireu Park Jae Hwa Jung Myeongjee Lee Soo Yeon Kim Min Jung Kim Yoon Hee Kim Kyung Won Kim Myung Hyun Sohn SpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure
description	Abstract The high-flow nasal cannula (HFNC) is a useful treatment modality for acute hypoxemic respiratory failure (AHRF) in children. We compared the ability of the oxygen saturation to fraction of inspired oxygen ratio (S/F) and arterial oxygen partial pressure to fraction of inspired oxygen ratio (P/F) to predict HFNC outcomes in children with AHRF. This study included children treated with HFNC due to AHRF from April 2013 to March 2019 at the Severance Children’s Hospital. HFNC failure was defined as the need for mechanical ventilation. Trends of S/F and P/F during HFNC were analyzed. To predict HFNC outcomes, a nomogram was constructed based on predictive factors. A total of 139 patients with arterial blood gas data were included in the S/F and P/F analyses. S/F < 230 at initiation showed high prediction accuracy for HFNC failure (area under the receiver operating characteristic curve: 0.751). Univariate analyses identified S/F < 230 at HFNC initiation and < 200 at 2 h (odds ratio [OR] 12.83, 95% CI 5.06–35.84), and hemato-oncologic disease (OR 3.79, 95% CI 1.12–12.78) as significant predictive factors of HFNC failure. The constructed nomogram had a highly predictive performance, with a concordance index of 0.765 and 0.831 for the exploratory and validation groups, respectively. S/F may be used as a predictor of HFNC outcomes. Our nomogram with S/F for HFNC failure within 2 h may prevent delayed intubation in children with AHRF.
format	article
author	Ga Eun Kim Sun Ha Choi Mireu Park Jae Hwa Jung Myeongjee Lee Soo Yeon Kim Min Jung Kim Yoon Hee Kim Kyung Won Kim Myung Hyun Sohn
author_facet	Ga Eun Kim Sun Ha Choi Mireu Park Jae Hwa Jung Myeongjee Lee Soo Yeon Kim Min Jung Kim Yoon Hee Kim Kyung Won Kim Myung Hyun Sohn
author_sort	Ga Eun Kim
title	SpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure
title_short	SpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure
title_full	SpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure
title_fullStr	SpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure
title_full_unstemmed	SpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure
title_sort	spo2/fio2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2300af7058c4adfbf95ef13cf82f2ee
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SpO2/FiO2 as a predictor of high flow nasal cannula outcomes in children with acute hypoxemic respiratory failure

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