Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalian ADAR2.

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Autores principales:	Patricia Deng, Anzer Khan, Dionna Jacobson, Nagraj Sambrani, Leeanne McGurk, Xianghua Li, Aswathy Jayasree, Jan Hejatko, Galit Shohat-Ophir, Mary A. O’Connell, Jin Billy Li, Liam P. Keegan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2300f5bbdf84bf08236658c6672b294
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spelling	oai:doaj.org-article:f2300f5bbdf84bf08236658c6672b2942021-12-02T14:42:46ZAdar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila10.1038/s41467-020-15435-12041-1723https://doaj.org/article/f2300f5bbdf84bf08236658c6672b2942020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15435-1https://doaj.org/toc/2041-1723Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalian ADAR2.Patricia DengAnzer KhanDionna JacobsonNagraj SambraniLeeanne McGurkXianghua LiAswathy JayasreeJan HejatkoGalit Shohat-OphirMary A. O’ConnellJin Billy LiLiam P. KeeganNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia Deng Anzer Khan Dionna Jacobson Nagraj Sambrani Leeanne McGurk Xianghua Li Aswathy Jayasree Jan Hejatko Galit Shohat-Ophir Mary A. O’Connell Jin Billy Li Liam P. Keegan Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila
description	Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalian ADAR2.
format	article
author	Patricia Deng Anzer Khan Dionna Jacobson Nagraj Sambrani Leeanne McGurk Xianghua Li Aswathy Jayasree Jan Hejatko Galit Shohat-Ophir Mary A. O’Connell Jin Billy Li Liam P. Keegan
author_facet	Patricia Deng Anzer Khan Dionna Jacobson Nagraj Sambrani Leeanne McGurk Xianghua Li Aswathy Jayasree Jan Hejatko Galit Shohat-Ophir Mary A. O’Connell Jin Billy Li Liam P. Keegan
author_sort	Patricia Deng
title	Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila
title_short	Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila
title_full	Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila
title_fullStr	Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila
title_full_unstemmed	Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila
title_sort	adar rna editing-dependent and -independent effects are required for brain and innate immune functions in drosophila
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f2300f5bbdf84bf08236658c6672b294
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Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

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