Biosynthetic energy cost for amino acids decreases in cancer evolution
Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.
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Nature Portfolio
2018
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oai:doaj.org-article:f232eaedd2524fefb4a1b83537cf1e3a2021-12-02T14:39:44ZBiosynthetic energy cost for amino acids decreases in cancer evolution10.1038/s41467-018-06461-12041-1723https://doaj.org/article/f232eaedd2524fefb4a1b83537cf1e3a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06461-1https://doaj.org/toc/2041-1723Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.Hong ZhangYirong WangJun LiHan ChenXionglei HeHuiwen ZhangHan LiangJian LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Hong Zhang Yirong Wang Jun Li Han Chen Xionglei He Huiwen Zhang Han Liang Jian Lu Biosynthetic energy cost for amino acids decreases in cancer evolution |
description |
Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation. |
format |
article |
author |
Hong Zhang Yirong Wang Jun Li Han Chen Xionglei He Huiwen Zhang Han Liang Jian Lu |
author_facet |
Hong Zhang Yirong Wang Jun Li Han Chen Xionglei He Huiwen Zhang Han Liang Jian Lu |
author_sort |
Hong Zhang |
title |
Biosynthetic energy cost for amino acids decreases in cancer evolution |
title_short |
Biosynthetic energy cost for amino acids decreases in cancer evolution |
title_full |
Biosynthetic energy cost for amino acids decreases in cancer evolution |
title_fullStr |
Biosynthetic energy cost for amino acids decreases in cancer evolution |
title_full_unstemmed |
Biosynthetic energy cost for amino acids decreases in cancer evolution |
title_sort |
biosynthetic energy cost for amino acids decreases in cancer evolution |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/f232eaedd2524fefb4a1b83537cf1e3a |
work_keys_str_mv |
AT hongzhang biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT yirongwang biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT junli biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT hanchen biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT xiongleihe biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT huiwenzhang biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT hanliang biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT jianlu biosyntheticenergycostforaminoacidsdecreasesincancerevolution |
_version_ |
1718390569536847872 |