Biosynthetic energy cost for amino acids decreases in cancer evolution

Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.

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Autores principales: Hong Zhang, Yirong Wang, Jun Li, Han Chen, Xionglei He, Huiwen Zhang, Han Liang, Jian Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f232eaedd2524fefb4a1b83537cf1e3a
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spelling oai:doaj.org-article:f232eaedd2524fefb4a1b83537cf1e3a2021-12-02T14:39:44ZBiosynthetic energy cost for amino acids decreases in cancer evolution10.1038/s41467-018-06461-12041-1723https://doaj.org/article/f232eaedd2524fefb4a1b83537cf1e3a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06461-1https://doaj.org/toc/2041-1723Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.Hong ZhangYirong WangJun LiHan ChenXionglei HeHuiwen ZhangHan LiangJian LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hong Zhang
Yirong Wang
Jun Li
Han Chen
Xionglei He
Huiwen Zhang
Han Liang
Jian Lu
Biosynthetic energy cost for amino acids decreases in cancer evolution
description Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.
format article
author Hong Zhang
Yirong Wang
Jun Li
Han Chen
Xionglei He
Huiwen Zhang
Han Liang
Jian Lu
author_facet Hong Zhang
Yirong Wang
Jun Li
Han Chen
Xionglei He
Huiwen Zhang
Han Liang
Jian Lu
author_sort Hong Zhang
title Biosynthetic energy cost for amino acids decreases in cancer evolution
title_short Biosynthetic energy cost for amino acids decreases in cancer evolution
title_full Biosynthetic energy cost for amino acids decreases in cancer evolution
title_fullStr Biosynthetic energy cost for amino acids decreases in cancer evolution
title_full_unstemmed Biosynthetic energy cost for amino acids decreases in cancer evolution
title_sort biosynthetic energy cost for amino acids decreases in cancer evolution
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f232eaedd2524fefb4a1b83537cf1e3a
work_keys_str_mv AT hongzhang biosyntheticenergycostforaminoacidsdecreasesincancerevolution
AT yirongwang biosyntheticenergycostforaminoacidsdecreasesincancerevolution
AT junli biosyntheticenergycostforaminoacidsdecreasesincancerevolution
AT hanchen biosyntheticenergycostforaminoacidsdecreasesincancerevolution
AT xiongleihe biosyntheticenergycostforaminoacidsdecreasesincancerevolution
AT huiwenzhang biosyntheticenergycostforaminoacidsdecreasesincancerevolution
AT hanliang biosyntheticenergycostforaminoacidsdecreasesincancerevolution
AT jianlu biosyntheticenergycostforaminoacidsdecreasesincancerevolution
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