Biosynthetic energy cost for amino acids decreases in cancer evolution

Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.

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Auteurs principaux:	Hong Zhang, Yirong Wang, Jun Li, Han Chen, Xionglei He, Huiwen Zhang, Han Liang, Jian Lu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f232eaedd2524fefb4a1b83537cf1e3a
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spelling	oai:doaj.org-article:f232eaedd2524fefb4a1b83537cf1e3a2021-12-02T14:39:44ZBiosynthetic energy cost for amino acids decreases in cancer evolution10.1038/s41467-018-06461-12041-1723https://doaj.org/article/f232eaedd2524fefb4a1b83537cf1e3a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06461-1https://doaj.org/toc/2041-1723Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.Hong ZhangYirong WangJun LiHan ChenXionglei HeHuiwen ZhangHan LiangJian LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong Zhang Yirong Wang Jun Li Han Chen Xionglei He Huiwen Zhang Han Liang Jian Lu Biosynthetic energy cost for amino acids decreases in cancer evolution
description	Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.
format	article
author	Hong Zhang Yirong Wang Jun Li Han Chen Xionglei He Huiwen Zhang Han Liang Jian Lu
author_facet	Hong Zhang Yirong Wang Jun Li Han Chen Xionglei He Huiwen Zhang Han Liang Jian Lu
author_sort	Hong Zhang
title	Biosynthetic energy cost for amino acids decreases in cancer evolution
title_short	Biosynthetic energy cost for amino acids decreases in cancer evolution
title_full	Biosynthetic energy cost for amino acids decreases in cancer evolution
title_fullStr	Biosynthetic energy cost for amino acids decreases in cancer evolution
title_full_unstemmed	Biosynthetic energy cost for amino acids decreases in cancer evolution
title_sort	biosynthetic energy cost for amino acids decreases in cancer evolution
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f232eaedd2524fefb4a1b83537cf1e3a
work_keys_str_mv	AT hongzhang biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT yirongwang biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT junli biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT hanchen biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT xiongleihe biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT huiwenzhang biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT hanliang biosyntheticenergycostforaminoacidsdecreasesincancerevolution AT jianlu biosyntheticenergycostforaminoacidsdecreasesincancerevolution
_version_	1718390569536847872

Biosynthetic energy cost for amino acids decreases in cancer evolution

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