An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos

An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos

Early human embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here the authors present LiCAT-seq, a method enabling simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells and map chromatin accessibility...

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Main Authors: Longqi Liu, Lizhi Leng, Chuanyu Liu, Changfu Lu, Yue Yuan, Liang Wu, Fei Gong, Shuoping Zhang, Xiaoyu Wei, Mingyue Wang, Lei Zhao, Liang Hu, Jian Wang, Huanming Yang, Shida Zhu, Fang Chen, Guangxiu Lu, Zhouchun Shang, Ge Lin
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/f2377bee5d8a4fa08fc7cda946aac81e
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Summary:Early human embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here the authors present LiCAT-seq, a method enabling simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells and map chromatin accessibility and transcriptome landscapes for human pre-implantation embryos.

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