Determination of split renal function using dynamic CT-angiography: preliminary results.

<h4>Objectives</h4>To determine the feasibility of a dynamic CT angiography-protocol with regard to simultaneous assessment of renal anatomy and function.<h4>Methods</h4>7 healthy potential kidney donors (58 ± 7 years) underwent a dynamic computed tomography angiography (CTA)...

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Autores principales:	Andreas Helck, Ulf Schönermarck, Antje Habicht, Mike Notohamiprodjo, Manfred Stangl, Ernst Klotz, Konstantin Nikolaou, Christian la Fougère, Dirk Andrè Clevert, Maximilian Reiser, Christoph Becker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2379791a1e644caaaa33921a6bdc2d4
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spelling	oai:doaj.org-article:f2379791a1e644caaaa33921a6bdc2d42021-11-18T08:28:37ZDetermination of split renal function using dynamic CT-angiography: preliminary results.1932-620310.1371/journal.pone.0091774https://doaj.org/article/f2379791a1e644caaaa33921a6bdc2d42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24618919/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>To determine the feasibility of a dynamic CT angiography-protocol with regard to simultaneous assessment of renal anatomy and function.<h4>Methods</h4>7 healthy potential kidney donors (58 ± 7 years) underwent a dynamic computed tomography angiography (CTA) using a 128-slice CT-scanner with continuous bi-directional table movement, allowing the coverage of a scan range of 18 cm within 1.75 sec. Twelve scans of the kidneys (n = 14) were acquired every 3.5 seconds with the aim to simultaneously obtain CTA and renal function data. Image quality was assessed quantitatively (HU-measurements) and qualitatively (grade 1-4, 1 = best). The glomerular filtration rate (GFR) was calculated by a modified Patlak method and compared with the split renal function obtained with renal scintigraphy.<h4>Results</h4>Mean maximum attenuation was 464 ± 58 HU, 435 ± 48 HU and 277 ± 29 HU in the aorta, renal arteries, and renal veins, respectively. The abdominal aorta and all renal vessels were depicted excellently (grade 1.0). The image quality score for cortex differentiation was 1.6 ± 0.49, for the renal parenchyma 2.4 ± 0.49. GFR obtained from dynamic CTA correlated well with renal scintigraphy with a correlation coefficient of r = 0.84; P = 0.0002 (n = 14). The average absolute deviation was 1.6 mL/min. The average effective dose was 8.96 mSv.<h4>Conclusion</h4>Comprehensive assessment of renal anatomy and function is feasible using a single dynamic CT angiography examination. The proposed protocol may help to improve management in case of asymmetric kidney function as well as to simplify evaluation of potential living kidney donors.Andreas HelckUlf SchönermarckAntje HabichtMike NotohamiprodjoManfred StanglErnst KlotzKonstantin NikolaouChristian la FougèreDirk Andrè ClevertMaximilian ReiserChristoph BeckerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e91774 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andreas Helck Ulf Schönermarck Antje Habicht Mike Notohamiprodjo Manfred Stangl Ernst Klotz Konstantin Nikolaou Christian la Fougère Dirk Andrè Clevert Maximilian Reiser Christoph Becker Determination of split renal function using dynamic CT-angiography: preliminary results.
description	<h4>Objectives</h4>To determine the feasibility of a dynamic CT angiography-protocol with regard to simultaneous assessment of renal anatomy and function.<h4>Methods</h4>7 healthy potential kidney donors (58 ± 7 years) underwent a dynamic computed tomography angiography (CTA) using a 128-slice CT-scanner with continuous bi-directional table movement, allowing the coverage of a scan range of 18 cm within 1.75 sec. Twelve scans of the kidneys (n = 14) were acquired every 3.5 seconds with the aim to simultaneously obtain CTA and renal function data. Image quality was assessed quantitatively (HU-measurements) and qualitatively (grade 1-4, 1 = best). The glomerular filtration rate (GFR) was calculated by a modified Patlak method and compared with the split renal function obtained with renal scintigraphy.<h4>Results</h4>Mean maximum attenuation was 464 ± 58 HU, 435 ± 48 HU and 277 ± 29 HU in the aorta, renal arteries, and renal veins, respectively. The abdominal aorta and all renal vessels were depicted excellently (grade 1.0). The image quality score for cortex differentiation was 1.6 ± 0.49, for the renal parenchyma 2.4 ± 0.49. GFR obtained from dynamic CTA correlated well with renal scintigraphy with a correlation coefficient of r = 0.84; P = 0.0002 (n = 14). The average absolute deviation was 1.6 mL/min. The average effective dose was 8.96 mSv.<h4>Conclusion</h4>Comprehensive assessment of renal anatomy and function is feasible using a single dynamic CT angiography examination. The proposed protocol may help to improve management in case of asymmetric kidney function as well as to simplify evaluation of potential living kidney donors.
format	article
author	Andreas Helck Ulf Schönermarck Antje Habicht Mike Notohamiprodjo Manfred Stangl Ernst Klotz Konstantin Nikolaou Christian la Fougère Dirk Andrè Clevert Maximilian Reiser Christoph Becker
author_facet	Andreas Helck Ulf Schönermarck Antje Habicht Mike Notohamiprodjo Manfred Stangl Ernst Klotz Konstantin Nikolaou Christian la Fougère Dirk Andrè Clevert Maximilian Reiser Christoph Becker
author_sort	Andreas Helck
title	Determination of split renal function using dynamic CT-angiography: preliminary results.
title_short	Determination of split renal function using dynamic CT-angiography: preliminary results.
title_full	Determination of split renal function using dynamic CT-angiography: preliminary results.
title_fullStr	Determination of split renal function using dynamic CT-angiography: preliminary results.
title_full_unstemmed	Determination of split renal function using dynamic CT-angiography: preliminary results.
title_sort	determination of split renal function using dynamic ct-angiography: preliminary results.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/f2379791a1e644caaaa33921a6bdc2d4
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Determination of split renal function using dynamic CT-angiography: preliminary results.

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