Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro

Cancer cells, especially cancer stem cells (CSCs), are known for their therapeutic resistance and ability to induce a cancer relapse even many years after successful treatment. The quest for a novel protocol utilizing some commonly used non-oncologic drugs that would improve patients outcomes seems...

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Autores principales:	Magdalena Szaryńska, Agata Olejniczak-Kęder, Adrian Zubrzycki, Anna Wardowska, Zbigniew Kmieć
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer stem cells colorectal cancer anti-Fas aspirin dendritic cells Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f238bb1d04a6494ca9f44fcad3067636
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spelling	oai:doaj.org-article:f238bb1d04a6494ca9f44fcad30676362021-11-11T15:05:36ZAspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro10.3390/app1121100092076-3417https://doaj.org/article/f238bb1d04a6494ca9f44fcad30676362021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10009https://doaj.org/toc/2076-3417Cancer cells, especially cancer stem cells (CSCs), are known for their therapeutic resistance and ability to induce a cancer relapse even many years after successful treatment. The quest for a novel protocol utilizing some commonly used non-oncologic drugs that would improve patients outcomes seems to be the right solution. Aspirin (ASA) is one of such eminent drugs. Our study demonstrated that ASA may exert synergistic effect with the anti-Fas antibody on CSCs of colorectal cancer cell lines. We found that such compound treatment inhibited the pro-cancerous effect of anti-Fas stimulation and decreased spherogenicity, survival and CD133-positive cells’ count. Additionally, ASA with anti-Fas antibody may have a positive impact on dendritic cells’ functions. Our innovative study explored simultaneous usage of two biologically active compounds which haven’t been considered in such combination to assess their significance in colorectal cancer cell biology.Magdalena SzaryńskaAgata Olejniczak-KęderAdrian ZubrzyckiAnna WardowskaZbigniew KmiećMDPI AGarticlecancer stem cellscolorectal canceranti-Fasaspirindendritic cellsTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10009, p 10009 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer stem cells colorectal cancer anti-Fas aspirin dendritic cells Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	cancer stem cells colorectal cancer anti-Fas aspirin dendritic cells Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Magdalena Szaryńska Agata Olejniczak-Kęder Adrian Zubrzycki Anna Wardowska Zbigniew Kmieć Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro
description	Cancer cells, especially cancer stem cells (CSCs), are known for their therapeutic resistance and ability to induce a cancer relapse even many years after successful treatment. The quest for a novel protocol utilizing some commonly used non-oncologic drugs that would improve patients outcomes seems to be the right solution. Aspirin (ASA) is one of such eminent drugs. Our study demonstrated that ASA may exert synergistic effect with the anti-Fas antibody on CSCs of colorectal cancer cell lines. We found that such compound treatment inhibited the pro-cancerous effect of anti-Fas stimulation and decreased spherogenicity, survival and CD133-positive cells’ count. Additionally, ASA with anti-Fas antibody may have a positive impact on dendritic cells’ functions. Our innovative study explored simultaneous usage of two biologically active compounds which haven’t been considered in such combination to assess their significance in colorectal cancer cell biology.
format	article
author	Magdalena Szaryńska Agata Olejniczak-Kęder Adrian Zubrzycki Anna Wardowska Zbigniew Kmieć
author_facet	Magdalena Szaryńska Agata Olejniczak-Kęder Adrian Zubrzycki Anna Wardowska Zbigniew Kmieć
author_sort	Magdalena Szaryńska
title	Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro
title_short	Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro
title_full	Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro
title_fullStr	Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro
title_full_unstemmed	Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro
title_sort	aspirin exerts synergistic effect with anti-fas stimulation against colorectal cancer stem cells in vitro
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f238bb1d04a6494ca9f44fcad3067636
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Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro

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