Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Efthymia Vokali, Shann S. Yu, Sachiko Hirosue, Marcela Rinçon-Restrepo, Fernanda V. Duraes, Stefanie Scherer, Patricia Corthésy-Henrioud, Witold W. Kilarski, Anna Mondino, Dietmar Zehn, Stéphanie Hugues, Melody A. Swartz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f23b98b899c044b5baa15c4c746b6da2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f23b98b899c044b5baa15c4c746b6da2
record_format	dspace
spelling	oai:doaj.org-article:f23b98b899c044b5baa15c4c746b6da22021-12-02T17:32:58ZLymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions10.1038/s41467-019-14127-92041-1723https://doaj.org/article/f23b98b899c044b5baa15c4c746b6da22020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14127-9https://doaj.org/toc/2041-1723Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.Efthymia VokaliShann S. YuSachiko HirosueMarcela Rinçon-RestrepoFernanda V. DuraesStefanie SchererPatricia Corthésy-HenrioudWitold W. KilarskiAnna MondinoDietmar ZehnStéphanie HuguesMelody A. SwartzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Efthymia Vokali Shann S. Yu Sachiko Hirosue Marcela Rinçon-Restrepo Fernanda V. Duraes Stefanie Scherer Patricia Corthésy-Henrioud Witold W. Kilarski Anna Mondino Dietmar Zehn Stéphanie Hugues Melody A. Swartz Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
description	Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.
format	article
author	Efthymia Vokali Shann S. Yu Sachiko Hirosue Marcela Rinçon-Restrepo Fernanda V. Duraes Stefanie Scherer Patricia Corthésy-Henrioud Witold W. Kilarski Anna Mondino Dietmar Zehn Stéphanie Hugues Melody A. Swartz
author_facet	Efthymia Vokali Shann S. Yu Sachiko Hirosue Marcela Rinçon-Restrepo Fernanda V. Duraes Stefanie Scherer Patricia Corthésy-Henrioud Witold W. Kilarski Anna Mondino Dietmar Zehn Stéphanie Hugues Melody A. Swartz
author_sort	Efthymia Vokali
title	Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
title_short	Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
title_full	Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
title_fullStr	Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
title_full_unstemmed	Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
title_sort	lymphatic endothelial cells prime naïve cd8+ t cells into memory cells under steady-state conditions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f23b98b899c044b5baa15c4c746b6da2
work_keys_str_mv	AT efthymiavokali lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT shannsyu lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT sachikohirosue lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT marcelarinconrestrepo lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT fernandavduraes lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT stefaniescherer lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT patriciacorthesyhenrioud lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT witoldwkilarski lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT annamondino lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT dietmarzehn lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT stephaniehugues lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions AT melodyaswartz lymphaticendothelialcellsprimenaivecd8tcellsintomemorycellsundersteadystateconditions
_version_	1718380158607425536

Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

Ejemplares similares