Invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study

Jenna-Lynn Senger,1 Scott J Adams,2 Rani Kanthan3 1Division of Plastic Surgery, University of Alberta, Edmonton, AB, Canada; 2College of Medicine, 3Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada Abstract: Male breast cancer is rare, comprising only...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Senger JL, Adams SJ, Kanthan R
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://doaj.org/article/f23d2af45386425c9b7a7f3b7c9bccca
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f23d2af45386425c9b7a7f3b7c9bccca
record_format dspace
spelling oai:doaj.org-article:f23d2af45386425c9b7a7f3b7c9bccca2021-12-02T01:19:28ZInvasive lobular carcinoma of the male breast – a systematic review with an illustrative case study1179-1314https://doaj.org/article/f23d2af45386425c9b7a7f3b7c9bccca2017-05-01T00:00:00Zhttps://www.dovepress.com/invasive-lobular-carcinoma-of-the-male-breast-a-systematic-review-with-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Jenna-Lynn Senger,1 Scott J Adams,2 Rani Kanthan3 1Division of Plastic Surgery, University of Alberta, Edmonton, AB, Canada; 2College of Medicine, 3Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada Abstract: Male breast cancer is rare, comprising only 1% of all mammary cancers; invasive ductal carcinoma is by far the commonest subtype in both men and women. Though lobular breast cancer is the second most common subtype seen in women, such cancers are extremely uncommon in men, and this is likely related to the lack of lobular development in the male breast. Thus, due to the rarity of this subtype among breast cancers, compounded by the overall rarity of breast cancer in men, current understanding of the pathogenesis of this disease and its management is largely derived from case series and extrapolation of information from the larger cohort of female patients. This paper provides a systematic review on invasive lobular carcinoma of the male breast in the context of an illustrative case study. A comprehensive analysis of the National Cancer Institute’s Surveillance, Epidemiology, and End Results Data 1973–2013 leading to an exploration of the pathogenesis, epidemiology, clinical presentation, diagnosis, tumor characteristics, and management of lobular breast carcinoma in men is also discussed. Lobular subtype of breast cancer remains an enigmatic elusive disease that needs additional research to unravel its overall pathogenesis and molecular profile to provide insight for improved therapeutic management options. Keywords: male breast cancer, lobular breast carcinoma, e-cadherinSenger JLAdams SJKanthan RDove Medical Pressarticlemale breast cancerlobular breast carcinomae-cadherinNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 337-345 (2017)
institution DOAJ
collection DOAJ
language EN
topic male breast cancer
lobular breast carcinoma
e-cadherin
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle male breast cancer
lobular breast carcinoma
e-cadherin
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Senger JL
Adams SJ
Kanthan R
Invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study
description Jenna-Lynn Senger,1 Scott J Adams,2 Rani Kanthan3 1Division of Plastic Surgery, University of Alberta, Edmonton, AB, Canada; 2College of Medicine, 3Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada Abstract: Male breast cancer is rare, comprising only 1% of all mammary cancers; invasive ductal carcinoma is by far the commonest subtype in both men and women. Though lobular breast cancer is the second most common subtype seen in women, such cancers are extremely uncommon in men, and this is likely related to the lack of lobular development in the male breast. Thus, due to the rarity of this subtype among breast cancers, compounded by the overall rarity of breast cancer in men, current understanding of the pathogenesis of this disease and its management is largely derived from case series and extrapolation of information from the larger cohort of female patients. This paper provides a systematic review on invasive lobular carcinoma of the male breast in the context of an illustrative case study. A comprehensive analysis of the National Cancer Institute’s Surveillance, Epidemiology, and End Results Data 1973–2013 leading to an exploration of the pathogenesis, epidemiology, clinical presentation, diagnosis, tumor characteristics, and management of lobular breast carcinoma in men is also discussed. Lobular subtype of breast cancer remains an enigmatic elusive disease that needs additional research to unravel its overall pathogenesis and molecular profile to provide insight for improved therapeutic management options. Keywords: male breast cancer, lobular breast carcinoma, e-cadherin
format article
author Senger JL
Adams SJ
Kanthan R
author_facet Senger JL
Adams SJ
Kanthan R
author_sort Senger JL
title Invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study
title_short Invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study
title_full Invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study
title_fullStr Invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study
title_full_unstemmed Invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study
title_sort invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/f23d2af45386425c9b7a7f3b7c9bccca
work_keys_str_mv AT sengerjl invasivelobularcarcinomaofthemalebreastndashasystematicreviewwithanillustrativecasestudy
AT adamssj invasivelobularcarcinomaofthemalebreastndashasystematicreviewwithanillustrativecasestudy
AT kanthanr invasivelobularcarcinomaofthemalebreastndashasystematicreviewwithanillustrativecasestudy
_version_ 1718403171129229312