A model of stimulus-specific neural assemblies in the insect antennal lobe.

It has been proposed that synchronized neural assemblies in the antennal lobe of insects encode the identity of olfactory stimuli. In response to an odor, some projection neurons exhibit synchronous firing, phase-locked to the oscillations of the field potential, whereas others do not. Experimental...

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Autores principales:	Dominique Martinez, Noelia Montejo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f2440cf218e64d87a21feec29bc0a7b8
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spelling	oai:doaj.org-article:f2440cf218e64d87a21feec29bc0a7b82021-11-25T05:42:03ZA model of stimulus-specific neural assemblies in the insect antennal lobe.1553-734X1553-735810.1371/journal.pcbi.1000139https://doaj.org/article/f2440cf218e64d87a21feec29bc0a7b82008-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18795147/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358It has been proposed that synchronized neural assemblies in the antennal lobe of insects encode the identity of olfactory stimuli. In response to an odor, some projection neurons exhibit synchronous firing, phase-locked to the oscillations of the field potential, whereas others do not. Experimental data indicate that neural synchronization and field oscillations are induced by fast GABA(A)-type inhibition, but it remains unclear how desynchronization occurs. We hypothesize that slow inhibition plays a key role in desynchronizing projection neurons. Because synaptic noise is believed to be the dominant factor that limits neuronal reliability, we consider a computational model of the antennal lobe in which a population of oscillatory neurons interact through unreliable GABA(A) and GABA(B) inhibitory synapses. From theoretical analysis and extensive computer simulations, we show that transmission failures at slow GABA(B) synapses make the neural response unpredictable. Depending on the balance between GABA(A) and GABA(B) inputs, particular neurons may either synchronize or desynchronize. These findings suggest a wiring scheme that triggers stimulus-specific synchronized assemblies. Inhibitory connections are set by Hebbian learning and selectively activated by stimulus patterns to form a spiking associative memory whose storage capacity is comparable to that of classical binary-coded models. We conclude that fast inhibition acts in concert with slow inhibition to reformat the glomerular input into odor-specific synchronized neural assemblies.Dominique MartinezNoelia MontejoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 4, Iss 8, p e1000139 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Dominique Martinez Noelia Montejo A model of stimulus-specific neural assemblies in the insect antennal lobe.
description	It has been proposed that synchronized neural assemblies in the antennal lobe of insects encode the identity of olfactory stimuli. In response to an odor, some projection neurons exhibit synchronous firing, phase-locked to the oscillations of the field potential, whereas others do not. Experimental data indicate that neural synchronization and field oscillations are induced by fast GABA(A)-type inhibition, but it remains unclear how desynchronization occurs. We hypothesize that slow inhibition plays a key role in desynchronizing projection neurons. Because synaptic noise is believed to be the dominant factor that limits neuronal reliability, we consider a computational model of the antennal lobe in which a population of oscillatory neurons interact through unreliable GABA(A) and GABA(B) inhibitory synapses. From theoretical analysis and extensive computer simulations, we show that transmission failures at slow GABA(B) synapses make the neural response unpredictable. Depending on the balance between GABA(A) and GABA(B) inputs, particular neurons may either synchronize or desynchronize. These findings suggest a wiring scheme that triggers stimulus-specific synchronized assemblies. Inhibitory connections are set by Hebbian learning and selectively activated by stimulus patterns to form a spiking associative memory whose storage capacity is comparable to that of classical binary-coded models. We conclude that fast inhibition acts in concert with slow inhibition to reformat the glomerular input into odor-specific synchronized neural assemblies.
format	article
author	Dominique Martinez Noelia Montejo
author_facet	Dominique Martinez Noelia Montejo
author_sort	Dominique Martinez
title	A model of stimulus-specific neural assemblies in the insect antennal lobe.
title_short	A model of stimulus-specific neural assemblies in the insect antennal lobe.
title_full	A model of stimulus-specific neural assemblies in the insect antennal lobe.
title_fullStr	A model of stimulus-specific neural assemblies in the insect antennal lobe.
title_full_unstemmed	A model of stimulus-specific neural assemblies in the insect antennal lobe.
title_sort	model of stimulus-specific neural assemblies in the insect antennal lobe.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/f2440cf218e64d87a21feec29bc0a7b8
work_keys_str_mv	AT dominiquemartinez amodelofstimulusspecificneuralassembliesintheinsectantennallobe AT noeliamontejo amodelofstimulusspecificneuralassembliesintheinsectantennallobe AT dominiquemartinez modelofstimulusspecificneuralassembliesintheinsectantennallobe AT noeliamontejo modelofstimulusspecificneuralassembliesintheinsectantennallobe
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A model of stimulus-specific neural assemblies in the insect antennal lobe.

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