DIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD

Objective: To determine the diagnostic accuracy of IgA anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Pediatrics, Pak Emirates Military H...

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Autores principales:	Munir Akmal Lodhi, Zeeshan Saleem, Ammarah Ayub, Tehmina Munir, Shamama Hassan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	anti-tissue transglutaminase antibody celiac disease diagnostic accuracy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f248bd5cb3e24451b3b01c653c429ecb
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spelling	oai:doaj.org-article:f248bd5cb3e24451b3b01c653c429ecb2021-12-02T16:32:52ZDIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD0030-96482411-8842https://doaj.org/article/f248bd5cb3e24451b3b01c653c429ecb2021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/6655https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the diagnostic accuracy of IgA anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Pediatrics, Pak Emirates Military Hospital Rawalpindi, from Apr 2015 to Jul 2016. Methodology: Ninety five consecutive children presenting with suspicion of celiac disease were included into this study after taking written informed consent. A predesigned proforma was used to record patient’s demographic details. Anti-tTG level of ≥25 U/ml was taken as diagnostic of celiac disease while results of histopathology on endoscopic biopsy were taken as gold standard. Results: The mean age of the patients was 6.48 ± 3.20 years and majority 53 (55.8%) of the children were aged between 5-10 years. There were 47 (49.5%) male and 48 (50.5%) female children in the study group. The serum Anti-tTG level ranged from 8.0 U/ml to 759.0 U/ml with a mean of 298.75 ± 225.51 U/ml. Taking a cut-off value of ≥25 U/ml for anti-tTG, 81 (85.3%) children were suspected of celiac disease. Histopathology of endoscopic biopsy confirmed celiac disease in 68 (71.6%) children with 62 true positive, 19 false positive, 6 false negative and 8 true negative cases. It yielded 91.18% sensitivity, 29.63% specificity and 73.68% accuracy for anti-tTG (≥25 U/ml) in the diagnosis of celiac disease with positive and negative predictive values of 76.54% and 57.14% respectively. Conclusion: IgA anti-tissue transglutaminase antibody (≥25 U/ml) was found to be 91.18% sensitive, 29.63% specific and 73.68% accurate in the diagnosis of celiac disease taking histopathology as gold standard with positive and negative predictive values of 76.54% and 57.14% respectively.Munir Akmal LodhiZeeshan SaleemAmmarah AyubTehmina MunirShamama HassanArmy Medical College Rawalpindiarticleanti-tissue transglutaminase antibodyceliac diseasediagnostic accuracyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 418-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-tissue transglutaminase antibody celiac disease diagnostic accuracy Medicine R Medicine (General) R5-920
spellingShingle	anti-tissue transglutaminase antibody celiac disease diagnostic accuracy Medicine R Medicine (General) R5-920 Munir Akmal Lodhi Zeeshan Saleem Ammarah Ayub Tehmina Munir Shamama Hassan DIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD
description	Objective: To determine the diagnostic accuracy of IgA anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Pediatrics, Pak Emirates Military Hospital Rawalpindi, from Apr 2015 to Jul 2016. Methodology: Ninety five consecutive children presenting with suspicion of celiac disease were included into this study after taking written informed consent. A predesigned proforma was used to record patient’s demographic details. Anti-tTG level of ≥25 U/ml was taken as diagnostic of celiac disease while results of histopathology on endoscopic biopsy were taken as gold standard. Results: The mean age of the patients was 6.48 ± 3.20 years and majority 53 (55.8%) of the children were aged between 5-10 years. There were 47 (49.5%) male and 48 (50.5%) female children in the study group. The serum Anti-tTG level ranged from 8.0 U/ml to 759.0 U/ml with a mean of 298.75 ± 225.51 U/ml. Taking a cut-off value of ≥25 U/ml for anti-tTG, 81 (85.3%) children were suspected of celiac disease. Histopathology of endoscopic biopsy confirmed celiac disease in 68 (71.6%) children with 62 true positive, 19 false positive, 6 false negative and 8 true negative cases. It yielded 91.18% sensitivity, 29.63% specificity and 73.68% accuracy for anti-tTG (≥25 U/ml) in the diagnosis of celiac disease with positive and negative predictive values of 76.54% and 57.14% respectively. Conclusion: IgA anti-tissue transglutaminase antibody (≥25 U/ml) was found to be 91.18% sensitive, 29.63% specific and 73.68% accurate in the diagnosis of celiac disease taking histopathology as gold standard with positive and negative predictive values of 76.54% and 57.14% respectively.
format	article
author	Munir Akmal Lodhi Zeeshan Saleem Ammarah Ayub Tehmina Munir Shamama Hassan
author_facet	Munir Akmal Lodhi Zeeshan Saleem Ammarah Ayub Tehmina Munir Shamama Hassan
author_sort	Munir Akmal Lodhi
title	DIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD
title_short	DIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD
title_full	DIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD
title_fullStr	DIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD
title_full_unstemmed	DIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD
title_sort	diagnostic accuracy of iga anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/f248bd5cb3e24451b3b01c653c429ecb
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DIAGNOSTIC ACCURACY OF IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE TAKING HISTOPATHOLOGY AS GOLD STANDARD

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